Identification of novel VirR/VirS-regulated genes in Clostridium perfringens

Molecular Microbiology

Volumn 35, Issue 4, 2000, Pages 854-864

  Banu, Sayera ^a   Ohtani, Kaori ^a   Yaguchi, Harumi ^a   Swe, Tint ^a   Cole, Stewart T ^b   Hayashi, Hideo ^a   Shimizu, Tohru ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; BACTERIAL DNA; COMPLEMENTARY DNA; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYSTEINE SYNTHASE; MESSENGER RNA; PROTEIN TYROSINE PHOSPHATASE; REGULATOR PROTEIN; SYNTHETASE; TOXIN;

ARTICLE; BACTERIAL GENE; CLOSTRIDIUM PERFRINGENS; DNA HYBRIDIZATION; GENE CONTROL; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

BACTERIAL PROTEINS; CHROMOSOME MAPPING; CHROMOSOMES, BACTERIAL; CLOSTRIDIUM PERFRINGENS; DNA, BACTERIAL; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, BACTERIAL; GENE LIBRARY; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HYBRIDIZATION; REGULON; SEQUENCE ANALYSIS, DNA;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM PERFRINGENS; COLA; POSIBACTERIA; PROKARYOTA; VIR;

EID: 0033969359     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01760.x     Document Type: Article

References (38)

1. Aiba, H., Adhya, S., and de Crombrugghe, B. (1981) Evidence for two functional gal promoters in intact Escherichia coli cells. J Biol Chem 256: 11905-11910.
2. Altschul, S.F., Madden, T.L., Schäffer, A.A., Zhang, J., Zhang, Z., Miller, W., et al. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
3. Anderson, K., Carballeira, N., Magnusson, K.-E., Persson, C., Stendahl, O., Wolf-Watz, H., et al. (1996) YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis. Mol Microbiol 20: 1057-1069.
4. Awad, M.M., Bryant, A.E., Stevens, D.L., and Rood, J.I. (1995) Virulence studies on chromosomal α-toxin and θ-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of α-toxin in Clostridium perfringens-mediated gas gangrene. Mol Microbiol 15: 191-202.
5. Ba-Thein, W., Lyristis, M., Ohtani, K., Nisbet, I.T., Hayashi, H., Rood, J.I., et al. (1996) The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens. J Bacteriol 178: 2514-2520.
6. Bull, C.J., White, O., Olsen, G.J., Zhou, L., Fleischmann, R.D., Sutton, G.G., et al. (1996) Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science 273: 1058-1073.
7. Chuang, S.-E., Daniels, D.L., and Blattner, F.R. (1993) Global regulation of gene expression in Escherichia coli. J Bacteriol 175: 2026-2036.
8. Fleischmann, R.D., Adams, M.D., White, O., Clayton, R.A., Kirkness, E.F., Kerlavage, A.R., et al. (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269: 496-512.
9. Geck, P., Whitaker, S.A., Medveczky, M.M., and Medveczky, P.G. (1990) Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. J Virol 64: 3509-3515.
10. Gross, R. (1993) Signal transduction and virulence regulation in human and animal pathogens. FEMS Microbiol Rev 104: 301-326.
11. Hatheway, C.L. (1990) Toxigenic clostridia. Clin Microbiol Rev 3: 66-98.
12. Kaniga, K., Uralil, J., Bliska, J.B., and Galan, J.E. (1996) A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium. Mol Microbiol 21: 633-641.
13. Katayama, S.-I., Dupuy, B., Garnier, T., and Cole, S.T. (1995) Rapid expansion of the physical and genetic map of the chromosome of Clostridium perfringens CPN50. J Bacteriol 177: 5680-5685.
14. Kobayashi, T., Shimizu, T., and Hayashi, H. (1995) Transcriptional analysis of the β-galactosidase gene (pbg) in Clostridium perfringens. FEMS Microbiol Lett 133: 65-69.
15. Kunst, F., Ogasawara, N., Moszer, I., Albertini, A.M., Alloni, G., Azevedo, V., et al. (1997) The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature 390: 249-256.
16. Liu, J., Burns, D.M., and Beacham, I.R. (1986) Isolation and sequence analysis of the gene (cpdB) encoding periplasmic 2′,3′-cyclic phosphodiesterase. J Bacteriol 165: 1002-1010.
17. Lomovskaya, O., and Lewis, K. (1992) Emr, an Escherichia coli locus for multidrug resistance. Proc Natl Acad Sci USA 89: 8938-8942.
18. Lyristis, M., Bryant, A.E., Sloan, J., Awad, M.M., Nisbet, I.T., Stevens, D.L., et al. (1994) Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Mol Microbiol 12: 761-777.
19. McDonel, J.L. (1980) Clostridium perfringens toxins (type A, B, C, D, E). Pharmacol Ther 10: 617-635.
20. Mahony, D.E., and Moore, T.J. (1976) Stable L-forms of Clostridium perfringens and their growth on glass surfaces. Can J Microbiol 22: 953-959.
21. Matsushita, O., Yoshihara, K., Katayama, S.-I., Minami, J., and Okabe, A. (1994) Purification and characterization of a Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene. J Bacteriol 176: 149-156.
22. Miller, S.I., and Mekalanos, J.J. (1990) Constitutive expression of the phoP regulon attenuates Salmonella virulence and survival within macrophages. J Bacteriol 172: 2485-2490.
23. Miller, J.F., Mekalanos, J.J., and Falkow, S. (1989) Coordinate regulation and sensory transduction in the control of bacterial virulence. Science 243: 916-922.
24. Ogasawara, N., Nakai, S., and Yoshikawa, H. (1994) Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin. DNA Res 1: 1-14.
25. Ohtani, K., Bando, M., Swe, T., Banu, S., Oe, M., Hayashi, H., et al. (1997) Collagenase gene (colA) is located in the 3′-flanking region of the perfringolysin O (pfoA) locus in Clostridium perfringens. FEMS Microbiol Lett 146: 155-159.
26. Okabe, A., Shimizu, T., and Hayashi, H. (1989) Cloning and sequencing of a phospholipase C gene of Clostridium perfringens. Biochem Biophys Res Commun 160: 33-39.
27. Potts, M., Sun, H., Mockaitis, K., Kennelly, P.J., Reed, D., and Tonks, N.K. (1993) A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584. J Biol Chem 268: 7632-7635.
28. Rood, J.I., and Cole, S.T. (1991) Molecular genetics and pathogenesis of Clostridium perfringens. Microbiol Rev 55: 621-648.
29. Sambrook, J., Fritch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
30. Shimizu, T., Okabe, A., Minami, J., and Hayashi, H. (1991) An upstream regulatory sequence stimulates expression of the perfringolysin O gene of Clostridium perfringens. Infect Immun 59: 137-142.
31. Shimizu, T., Ba-Thein, W., Tamaki, M., and Hayashi, H. (1994) The virR gene, a member of a class of two-component response regulators, regulates the production of the perfringolysin O, collagenase, and hemagglutinin in Clostridium perfringens. J Bacteriol 176: 1616-1623.
32. Shimizu, T., Kobayashi, T., Ba-Thein, W., Ohtani, K., and Hayashi, H. (1995) Sequence analysis of flanking regions of the pfoA gene of Clostridium perfringens: β-galactosidase gene (pbg) is located in the 3′-flanking region. Microbiol Immunol 39: 677-686.
33. Shimizu, T., Okabe, A., and Rood, J.I. (1997) Regulation of toxin production in Clostridium perfringens. In The Clostridia: Molecular Biology and Pathogenesis. Rood, J.I., McClane, B.A., Songer, J.G., and Titball, R.W. (eds). London: Academic Press, pp. 451-470.
34. Sloan, J., Warner, T.A., Scott, P.T., Bannam, T.L., Berryman, D.I., and Rood, J.I. (1992) Construction of a sequenced Clostridium perfringens-Escherichia coli shuttle plasmid. Plasmid 27: 207-219.
35. Stock, J.B., Ninfa, A.J., and Stock, A.M. (1989) Protein phosphorylation and regulation of adaptive response in bacteria. Microbiol Rev 53: 450-490.
36. Tomb, J.F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539-547.
37. Volk, R., Koster, M., Poting, A., Hartmann, L., and Knochel, W. (1989) An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionary conserved 24 kDa protein. EMBO J 8: 2983-2988.
38. Yanisch-Perron, C., Vieria, J., and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequence of the M13mp18 and pUC19 vectors. Gene 33: 103-119.