Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes

Arthritis Research

Volumn 4, Issue 2, 2002, Pages 80-83

  Link, Jason M ^a   Schroeder, Harry W ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Autoantibody; B cell; Development; Immunoglobulin genes; Sequence analysis

Indexed keywords

ANTIGEN; AUTOANTIBODY; IMMUNOGLOBULIN;

ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; GENE SEQUENCE; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR CLONING; ONTOGENY; PATHOGENESIS; T LYMPHOCYTE;

ANIMALS; ANTIBODY DIVERSITY; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; DNA MUTATIONAL ANALYSIS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS;

EID: 0036196765     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar393     Document Type: Article

References (25)

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2. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
3. Regulation of the assembly and expression of variable-region genes
4. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
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6. Receptor editing in a transgenic mouse model: Site, efficiency, and role in B cell tolerance and antibody diversification
7. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
8. Sequences of proteins of immunological interest
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10. Anatomy of the antibody molecule
11. Regulation of the antibody repertoire through control of HCDR3 diversity
12. IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth
13. Developmentally restricted VH gene is expressed at high frequency in Chronic Lymphocytic Leukemia
14. Chronic lymphocytic leukemia: A proliferation of B cells at two distinct stages of differentiation
15. Constraints on hydropathicity and sequence composition of HCDR3 are conserved across evolution
16. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
17. Atypical VH-D-JH rearrangements in newborn autoimmune MRL mice
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19. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
20. Human B cells expressing surrogate light chains show increased receptor editing and accumulate in rheumatoid synovia
21. Use of immunoglobulin variable-region genes by normal subjects and patients with systemic lupus erythematosus
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24. Affinity maturation in ectopic germinal centers
25. Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue