Contribution of an imidazole-indole stack to high catalytic potency of a lysine-specific serine protease, Achromobacter protease I

Journal of Biochemistry

Volumn 131, Issue 2, 2002, Pages 213-218

  Shiraki, Kentaro ^a   Norioka, Shigemi ^a   Li, Shaoliang ^a   Sakiyama, Fumio ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b International Buddhist University   (Japan)

Author keywords

Aromatic stacking; Catalytic triad; Serine protease; Site directed mutagenesis

Indexed keywords

AMIDE; COUMARIN DERIVATIVE; HISTIDINE; IMIDAZOLE; INDOLE; LYSINE; SERINE PROTEINASE; TRYPSIN;

ACHROMOBACTER; ARTICLE; CATTLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; NONHUMAN;

ALCALIGENES; ANIMALS; BINDING SITES; CATALYSIS; CATTLE; DNA PRIMERS; IMIDAZOLES; INDOLES; KINETICS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TRYPSIN;

ACHROMOBACTER; BOS TAURUS; BOVINAE;

EID: 0036191129     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a003090     Document Type: Article

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