Inhibition of MEK1,2/ERK mitogenic pathway by estrogen with antiproliferative properties in rat aortic smooth muscle cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 80, Issue 1, 2002, Pages 85-90

  Hwang, Ki Chul ^a   Lee, Kyung Hye ^a   Jang, Yangsoo ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Aortic smooth muscle cell; Cell proliferation; Estrogen; MEK1,2 ERK

Indexed keywords

ESTROGEN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTO ONCOGENE; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ANIMALS; AORTA; CELL DIVISION; DNA-BINDING PROTEINS; ESTROGENS; ETS-DOMAIN PROTEIN ELK-1; GENE EXPRESSION REGULATION; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS;

BOVINAE; CERVUS ELAPHUS;

EID: 0036183322     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(01)00169-8     Document Type: Article

References (32)

1. The pathogenesis of atherosclerosis - An update
2. Differential response in cell proliferation to β-estradiol in coronary arterial vascular smooth muscle cells obtained from mature female versus male animals
3. Action of natural estrogen on the vessel wall: Molecular mechanisms and clinical implications
4. Vascular protection with estrogen. In-vitro and in-vivo effects-mechanisms and clinical implication
5. Selective estrogen receptor modulators - A new age of estrogens in cardiovascular disease?
6. Estrogen receptors: Bioactivities and interactions with cell signaling pathways
7. Routing MAP kinase cascades
8. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
9. Regulation and function of the JNK subgroup of MAP kinases
10. The role of c-jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
11. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
12. Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase
13. The primary structure of p38 gamma: A new member of p38 group of MAP kinases
14. Signalling via stress-activated mitogen-activated protein kinases in the cardiovascular system
15. Identification of MAP kinase domains by redirecting stress signals into growth factor responses
16. Induction of apotosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
17. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
18. Regulation of distinct stages of skeletal muscle differentiation by mitogen-activated protein kinases
19. The smooth muscle cell in culture
20. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays
21. Effect of estrogen on vascular smooth muscle cells in dependent upon cellular phenotype
22. Estrogen inhibits cuff-induced intimal thickening of rat femoral artery: Effects on migration and proliferation of vascular smooth muscle cells
23. Effects of 17β-estradiol and progesterone on growth-factor-induced proliferation and migration in human female aortic smooth muscle cells in vitro
24. Oestradiol inhibits smooth muscle cell proliferation of pig coronary artery
25. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
26. Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype
27. Estrogen reduces proliferation and agonist-induced calcium increase in coronary artery smooth muscle cells
28. 17β-estradiol inhibites proliferation and migration of human vascular smooth muscle cell: Similar effects in cells from postmenopausal females and males
29. Estrogen receptors α and β: Two receptors of a kind?
30. Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor β
31. Mitogen-activating protein kinase: Conservation of a three-kinase module from yeast to human