Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats

Psychopharmacology

Volumn 160, Issue 1, 2002, Pages 1-8

  Németh, Hajnalka ^a   Varga, Hedvig ^a   Farkas, Tamás ^a   Kis, Zsolt ^a   Vécsei, László ^a   Horváth, Szatmár ^a   Boda, Krisztina ^a   Wolff, Joachim R ^b   Toldi, József ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Cortical plasticity; Disinhibition; Evoked potential; MK 801; NMDA receptor; Primary motor cortex; Spatial learning; Water maze

Indexed keywords

DIZOCILPINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; BODY WEIGHT; BRAIN DEPTH STIMULATION; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; EVOKED RESPONSE; LATENT PERIOD; LEARNING; LEARNING DISORDER; MALE; MAZE TEST; MEMORY; MOTOR CORTEX; NEWBORN; NONHUMAN; PERINATAL PERIOD; PLASTICITY; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; CUES; DENERVATION; DIZOCILPINE MALEATE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; FACIAL NERVE; FEMALE; MALE; MAZE LEARNING; NEURONAL PLASTICITY; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; VIBRISSAE;

EID: 0036182171     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-001-0957-2     Document Type: Article

References (21)

1. A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat
2. The patterns and synaptic properties of horizontal intracortical connections in the rat motor cortex
3. Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning
4. Activation of the primary motor cortex by somatosensory stimulation in adult rats is mediated mainly by associational connections from the somatosensory cortex
5. Facial nerve injury-induced disinhibition in the primary motor cortices of both hemispheres
6. Injury-induced reorganization of somatosensory cortex is accompanied by reductions in GABA staining
7. Chronic neonatal MK-801 treatment results in an impairment of spatial learning in the adult rat
8. Immediate and long-term effects of neonatal MK-801 treatment on nonspatial learning
9. Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical motor maps
10. N-Methyl-D-aspartate receptor mediated component of field potentials evoked in horizontal pathways of rat motor cortex
11. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
12. Neuronal death enhanced by N-methyl-D-aspartate antagonists
13. MK-801 impedes the acquisition of a spatial memory task in rats
14. Serial injections of MK-801 (dizocilpine) in neonatal rats reduce behavioral deficits associated with X-ray-induced hippocampal granulare cell hypoplasia
15. MK-801 improves retention in aged rats: Implications for altered neural plasticity in age-related memory deficits
16. N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain
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20. Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain
21. Facial nerve injury produces a latent somatosensory input through recruitment of the motor cortex in the rat