Distinct cell type-specific expression of scaffolding proteins EBP50 and E3KARP: EBP50 is generally expressed with ezrin in specific epithelia, whereas E3KARP is not

European Journal of Cell Biology

Volumn 81, Issue 2, 2002, Pages 61-68

  Ingraffea, Janet ^a   Reczek, David ^a   Bretscher, Anthony ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

E3KARP; EBP50; Ezrin; Moesin; NHE RF; Radixin

Indexed keywords

ACTIN BINDING PROTEIN; BETA 2 ADRENERGIC RECEPTOR; BINDING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; EZRIN; MEMBRANE PROTEIN; MOESIN; PHOSPHOPROTEIN; PROTEIN ANTIBODY; PROTON; RADIXIN; REGULATOR PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHIOLE; CELL POLARITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPITHELIUM CELL; GLOMERULUS; HUMAN; HUMAN TISSUE; INTESTINE EPITHELIUM CELL; INTRAHEPATIC BILE DUCT; KIDNEY PROXIMAL TUBULE; LUNG ALVEOLUS; MESOTHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STOMACH MUCOSA; STOMACH PARIETAL CELL; TISSUE DISTRIBUTION;

ANIMALIA; GLOMERULUS; MURINAE;

EID: 0036181608     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00218     Document Type: Article

References (48)

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2. Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells
3. Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney
4. Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells
5. Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor
6. Regulation of cortical structure by the ezrin-radixin-moesin protein family
7. ERM-merlin and EBP50 protein families in plasma membrane organization and function
8. Villin associates with specific microfilamentous structures as seen by immunofluorescence microscopy on tissue sections and cells micro-injected with villin
9. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor
10. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout
11. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein
12. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
13. + exchanger regulatory factor family of PDZ proteins
14. + exchange
15. The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli
16. Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change
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18. Moesin: A member of the protein 4.1-talin-ezrin family of proteins
19. ERM proteins in cell adhesion and membrane dynamics
20. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
21. Activation of ERM proteins in vivo by rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases
22. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50
23. A PDZ-interacting domain in CFTR is an apical membrane polarization signal
24. The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane
25. Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets
26. Regulation of F-actin binding to platelet moesin In vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides
27. Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
28. Protein kinase C-theta phosphorylation of moesin in the actin-binding sequence
29. Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
30. The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule
31. Identification of EPI64, a TBC/ rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
32. + exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat
33. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites
34. Differential expression of the microspike-associated protein moesin in human tissues
35. Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain
36. An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton
37. C-terminal threonine phosphorylation activates ERM proteins to link the cell's cortical lipid bilayer to the cytoskeleton
38. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members
39. A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: Purification and characterization
40. Cortical actin organization: Lessons from ERM (Ezrin/Radixin/Moesin) proteins
41. Characterization of an 80-kDa phosphoprotein involved in parietal cell stimulation
42. Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)
43. + exchanger
44. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3
45. + exchanger requires a dissociable phosphoprotein cofactor
46. + exchanger
47. + exchanger NHE3 and the cytoskeletal protein ezrin
48. + exchanger, NHE3, requires an associated regulatory protein