Trypanosoma cruzi mitochondrial malate dehydrogenase triggers polyclonal B-cell activation

Clinical and Experimental Immunology

Volumn 127, Issue 1, 2002, Pages 27-36

  Montes, C L ^a   Zuniga E I ^a   Vazquez, J ^b   Arce, C ^a   Gruppi, A ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Chagas' disease; Malate dehydrogenase; Polyclonal B cell activation; Trypanosoma cruzi

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MALATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; OXIDOREDUCTASE;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURFACE; CHAGAS DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; EPIMASTIGOTE; FLOW CYTOMETRY; LYMPHOCYTE ACTIVATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN SYNTHESIS; SECRETORY CELL; T LYMPHOCYTE; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; ANTIBODY FORMATION; ANTIGENS, PROTOZOAN; B-LYMPHOCYTES; CHAGAS DISEASE; LYMPHOCYTE ACTIVATION; MALATE DEHYDROGENASE; MICE; MICE, INBRED BALB C; MITOCHONDRIA; TRYPANOSOMA CRUZI;

EID: 0036181441     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01746.x     Document Type: Article

References (37)

1. Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease
2. Studies on the thymus in Chagas' disease. II. Thymocyte subset fluctuations in Trypanosoma cruzi-infected mice: Relationship to stress
3. Polyclonal lymphocyte response to murine Trypanosoma cruzi infection. I. Quantitation of both T- and B- cell responses
4. Susceptible mice present higher macrophage activation than resistant mice during infections with myotropic strains of Trypanosoma cruzi
5. Anti-Ia treatment modulates specific and polyclonal antibody responses in Trypanosoma cruzi-infected mice
6. Most B cells in acute Trypanosoma cruzi infection lack parasite specificity
7. Immunobiology of murine T. cruzi infection: The predominance of parasite-nonspecific responses and the activation of TCRI T cells
8. T-cell dependent polyclonal activation by soluble mycobacterial extracts of B cells in peripheral blood mononuclear cell populations from leprosy patients and normal donors
9. Influenza virus hemagglutinin induces differentiation of mature resting B cells and growth arrest of immature WEHI-231 lymphoma cells
10. Shistosoma japonicum soluble egg antigens activate naive B cells to produce antibodies: Definition of parasite mechanisms of immune deviation
11. Release of lipopolysaccharide (LPS) from cell surface of Trypanosoma cruzi by EDTA
12. 24000 MW Trypanosoma cruzi antigen is a B-cell activator
13. Trypanosoma cruzi cytosolic alkaline antigens (FI) induce polyclonal activation in murine normal B cells
14. A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase
15. Trypanosoma cruzi alkaline antigen induces polyclonal B-cell activation of normal murine spleen cells by T-cell-independent, BCR-directed stimulation
16. Lymphocyte polyclonal activation: A pitfall for vaccine design against infectious agents
17. Growth and differentiation in T. cruzi origen of meta-cyclic trypanosomes in liquid media
18. Characterization of responses of normal human T cells to Trypanosoma cruzi antigens
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Isolation of microgram quantities of protein from polyacrylamide gels for amino acid sequence analysis
21. Mass spectrometry sequencing of silver-stained polyacrylamide gels
22. Amplification of differentially displayed PCR products isolated from untreated denaturing polyacrylamide gels
23. High-sensitivity analysis and sequencing of peptides and proteins by quadrupole ion trap mass spectrometry
24. Identification of phosphorylation sites in proteins by nanospray quadrupole ion trap mass spectrometry
25. Tetrameric and dimeric malate dehydrogenase isoenzymes in Trypanosoma cruzi epimastigotes
26. L-Malate dehydrogenase from Bacillus subtilis
27. CpG motifs in bacterial DNA trigger direct B-cell activation
28. A vaccine carrier derived from Neisseria meningitidis with mitogenic activity for lymphocytes
29. Microbial induction of costimulatory activity for CD4 T-cell growth
30. Bacterial stimulators of macrophages
31. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
32. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
33. Infection with Trypanosoma cruzi selectively upregulates B7-2 molecules on macrophages and enhances their costimulatory activity
34. CD28/B7 Regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
35. Glycosomal and mitochondrial malate dehydrogenases in epimastigotes of Trypanosoma cruzi
36. Supression of polyclonal antibody production in Trypanosoma cruzi infected mice by treatment with anti-L3T4 antibodies
37. Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease