Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium

Cell Biochemistry and Function

Volumn 20, Issue 1, 2002, Pages 11-17

  Sugihara, Nobuhiro ^a   Ise, Hirohiko ^a   Negishi, Naoki ^a   Nikaido, Toshio ^a   Akaike, Toshihiro ^a,b  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Bile acid; Cytochrome P 450 (CYP); Drug metabolism; Hepatocytes; Synchronize

Indexed keywords

AMINOPYRINE N DEMETHYLASE; BILE ACID; COLLAGEN; CYTOCHROME P450 3A; GLYCOCHOLIC ACID; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 84; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ARTIFICIAL LIVER; BILE ACID METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRESPONDENCE ANALYSIS; CULTURE MEDIUM; DRUG DELIVERY SYSTEM; DRUG METABOLISM; ENZYME ACTIVITY; INCUBATION TIME; LIVER CELL; LIVER CELL CULTURE; MALE; MOUSE; NONHUMAN; OSCILLATION; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN SECRETION; TRANSCRIPTION REGULATION;

AMINOPYRINE N-DEMETHYLASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BILE ACIDS AND SALTS; BIOLOGICAL CLOCKS; CELLS, CULTURED; CULTURE MEDIA; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; GLYCOCHOLIC ACID; HEPATOCYTES; KINETICS; MALE; MICE; MICE, INBRED ICR; OXIDOREDUCTASES, N-DEMETHYLATING; RNA, MESSENGER;

EID: 0036181332     PISSN: 02636484     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbf.933     Document Type: Article

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