Polarity of α-galactosidase A uptake by renal tubule cells

Kidney International

Volumn 61, Issue SUPPL. 1, 2002, Pages

  Stern, Aaron S ^a   Klotman, Mary E ^a   Ioannou, Yiannis A ^a   Burrow, Christopher R ^a   Wilson, Patricia D ^a   Klotman, Paul E ^a   Lipkowitz, Michael S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Adeno associated virus; Fabry disease; Gene therapy

Indexed keywords

ALPHA GALACTOSIDASE; COLLAGEN; MANNOSE 6 PHOSPHATE; RECOMBINANT ENZYME;

CELL GROWTH; CELL SURFACE; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME MECHANISM; FABRY DISEASE; HUMAN; HUMAN CELL; INCUBATION TIME; KIDNEY CELL CULTURE; KIDNEY TUBULE CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TRANSPORT; TRANSGENE;

EID: 0036180718     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.0610s1052.x     Document Type: Conference Paper

References (14)

1. Enzymatic defect in Fabry's disease: Ceramidetrihexosidase deficiency
2. Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion
3. Synthesis and processing of alpha-galactosidase in human fibroblasts: Evidence for different mutations in Fabry disease
4. Alpha-galactosidase A deficient mice: A model of Fabry disease
5. Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer
6. Defined human renal tubular epithelia in culture: Growth, characterization, and hormonal response
7. A microtechnique for quantitative measurements of acid hydrolases in fibroblasts: Its application in diagnosis of Fabry disease and enzyme replacement studies
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10. In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys
11. Novel tools for production and purification of recombinant adeno associated virus vectors
12. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
13. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
14. Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors