6-Arylamino-5,8-quinazolinediones as potent inhibitors of endothelium-dependent vasorelaxation

European Journal of Medicinal Chemistry

Volumn 37, Issue 1, 2002, Pages 77-82

  Ryu, Chung Kyu ^a   Shin, Keun Hwa ^a   Seo, Ji Hui ^a   Kim, Hwa Jung ^a  

^a Ewha Womans University   (South Korea)

Author keywords

6 arylamino 5,8 quinazolinedione; Endothelium dependent vasorelaxation; Inhibitors; Isosteres

Indexed keywords

5,8 QUINAZOLINEDIONE; 6 [(PHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (3 FLUOROPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (3 IODOPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (3,4 DIFLUOROPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (4 BROMOPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (4 CHLOROPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (4 FLUOROPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (4 IODOPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (4 TRIFLUOROMETHOXYPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 [N (4 TRIFLUOROMETHYLPHENYL)AMINO] 5,8 QUINAZOLINEDIONE; 6 ANILINO 5,8 QUINOLINEQUINONE; ACETYLCHOLINE; AROMATIC AMINE; CESIUM ION; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG SYNTHESIS; ENDOTHELIUM; NONHUMAN; RAT; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; ENDOTHELIUM, VASCULAR; MALE; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATION;

EID: 0036176128     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01290-9     Document Type: Article

References (16)