Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 37, Issue 2, 2002, Pages 91-109

  Mustazza, Carlo ^a   Borioni, Anna ^a   Giudice, Maria Rosaria Del ^a   Gatta, Franco ^a   Ferretti, Rosella ^a   Meneguz, Annarita ^a   Volpe, Maria Teresa ^a   Lorenzini, Paola ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Acetylcholinesterase inhibitors; Alzheimer's disease; Carbamates; Rivastigmine

Indexed keywords

1 [(2 DIMETHYLCARBAMOYLOXYPHENYL)METHYL]PIPERIDINE; 1 [(2 HEXYLCARBAMOYLOXYPHENYL)METHYL]PIPERIDINE; 1 [(3 DIMETHYLCARBAMOYLOXYPHENYL)METHYL]PIPERIDINE; 1 [(3 HEXYLCARBAMOYLOXYPHENYL)METHYL]PIPERIDINE; 1 [1 (2 HEXYLCARBAMOYLOXYPHENYL)ETHYL]PIPERIDINE; 1 [1 (3 DIMETHYLCARBAMOYLOXYPHENYL)ETHYL]PIPERIDINE; 1 [1 (3 HEXYLCARBAMOYLOXYPHENYL)ETHYL]PIPERIDINE; 1 [2 (2 DIMETHYLCARBAMOYLOXYPHENYL)ETHYL]PIPERIDINE; 1 [2 (2 HEXYLCARBAMOYLOXYPHENYL)ETHYL]PIPERIDINE; 1 [2 (3 HEXYLCARBAMOYLOXYPHENYL)ETHYL]PIPERIDINE; 2 (2 DIMETHYLCARBAMOYLOXYPHENYL) 1 METHYLPIPERIDINE; 2 (2 HEXYLCARBAMOYLOXYPHENYL) 1 METHYLPIPERIDINE; 2 (3 DIMETHYLCARBAMOYLOXYPHENYL) 1 METHYLPIPERIDINE; 2 (3 HEXYLCARBAMOYLOXYPHENYL) 1 METHYLPIPERIDINE; 2 [(2 DIMETHYLCARBAMOYLOXYPHENYL)METHYL] 1 METHYLPIPERIDINE; 2 [(2 HEXYLCARBAMOYLOXYPHENYL)METHYL] 1 METHYLPIPERIDINE; 2 [(3 DIMETHYLCARBAMOYLOXYPHENYL)METHYL] 1 METHYLPIPERIDINE; 2 [(3 HEXYLCARBAMOYLOXYPHENYL)METHYL] 1 METHYLPIPERIDINE; 2 [2 (2 DIMETHYLCARBAMOYLOXYPHENYL)ETHYL] 1 METHYLPIPERIDINE; 2 [2 (2 HEXYLCARBAMOYLOXYPHENYL)ETHYL] 1 METHYLPIPERIDINE; 2 [2 (3 DIMETHYLCARBAMOYLOXYPHENYL)ETHYL] 1 METHYLPIPERIDINE; 2 [2 (3 HEXYLCARBAMOYLOXYPHENYL)ETHYL] 1 METHYLPIPERIDINE; ACETYLCHOLINESTERASE; CARBAMIC ACID DERIVATIVE; DONEPEZIL; GALANTAMINE; PIPERIDINE DERIVATIVE; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE TOXICITY; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LD 50; MALE; MOUSE; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; BRAIN; CARBAMATES; CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MICE; PHENYLCARBAMATES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036175431     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01324-1     Document Type: Article

References (54)