Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease

Kidney International

Volumn 61, Issue SUPPL. 1, 2002, Pages

  Witzgall, Ralph ^a   Krälnzlin, Bettina ^a   Gretz, Norbert ^a   Obermüller, Nicholas ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Albuminuria; CIC 5; FITC dextran; Megalin; Proteinuria

Indexed keywords

ALBUMIN; ANTIBODY; CHLORIDE CHANNEL; COMPLEMENTARY DNA; DEXTRAN; DNA; MEGALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOSOMAL DOMINANT DISORDER; CHRONIC KIDNEY FAILURE; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE MODEL; DRUG TARGETING; ENDOCYTOSIS; EPITHELIUM; GEL ELECTROPHORESIS; GENE MUTATION; GENE THERAPY; GLOMERULUS EPITHELIUM; KIDNEY COLLECTING TUBULE; KIDNEY POLYCYSTIC DISEASE; KIDNEY PROXIMAL TUBULE; MOLECULAR CLONING; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PROTEINURIA; RAT; TARGET ORGAN; URINALYSIS;

EID: 0036172748     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.0610s1132.x     Document Type: Conference Paper

References (64)

1. Bilateral polycystic disease of the kidneys: A follow-up of two hundred and eighty-four patients and their families
2. Polycystic kidney disease re-evaluated: A population-based study
3. Prognosis of adult onset polycystic kidney disease re-evaluated
4. The diagnosis and prognosis of autosomal dominant polycystic kidney disease
5. Factors affecting the progression of renal disease in autosomal dominant polycystic kidney disease
6. The success of Medicare's end-stage renal-disease program
7. Demography of dialysis and transplantation in Europe, 1984
8. Incidence causes of treated ESRD
9. Polycystic kidney disease patients on renal replacement therapy: Data from the Catalan renal registry
10. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16
11. PKD 2, a gene for polycystic kidney disease that encodes an integral membrane protein
12. Genetic heterogeneity of polycystic kidney disease in Europe
13. A study of genetic linkage heterogeneity in 35 adult-onset polycystic kidney disease families
14. Hereditary polycystic kidney disease (adult form): A microdissection study of two cases at an early stage of the disease
15. Use of lectins in the study of histogenesis of renal cysts
16. Cyst formation and growth in autosomal dominant polycystic kidney disease
17. Water channel expression in human ADPKD kidneys
18. Expression of aquaporins-1 and -2 during nephrogenesis and in autosomal dominant polycystic kidney disease
19. Gene transfer into the mammalian kidney: Direct retrovirus-transduction of regenerating tubular epithelial cells
20. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the post-ischemic kidney: Evidence for a heterogeneous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells
21. Adenoviral-mediated gene transfer to renal tubular cells in vivo
22. Molecular conjugate-mediated gene transfer into isolated human kidneys
23. Localization of the CHIP28 water channel in rat kidney
24. CHIP28 water channels are localized in constitutively water-permeable segments of the nephron
25. Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28
26. Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta
27. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels
28. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
29. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery
30. Kidney-targeted liposome-mediated gene transfer in mice
31. Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy
32. Nonviral gene delivery to the rat kidney with polyethylenimine
33. Glomerular filtration is required for transfection of proximal tubular cells in the rat kidney following injection of DNA complexes into the renal artery
34. Renal uptake of an 18-mer phosphorothioate oligonucleotide
35. Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy
36. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia
37. i cotransporter by antisense oligonucleotides
38. Adenovirus-induced release of epidermal growth factor and Pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis
39. Infectious entry pathway of adenovirus type 2
40. Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
41. DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action
42. Fusion of cationic liposomes with mammalian cells occurs after endocytosis
43. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery
44. Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides
45. Digoxigenin-labeled phosphorothioate oligonucleotides: A new tool for the study of cellular uptake
46. Differentiation and cell polarity during renal cyst formation in the Han:SPRD (cy/+) rat, a model for ADPKD
47. Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease
48. Factors relating to urinary protein excretion in children with autosomal dominant polycystic kidney disease
49. The angiotensin-converting enzyme genotype and microalbuminuria in autosomal dominant polycystic kidney disease
50. Effect of antihypertensive therapy on renal function and urinary albumin excretion in hypertensive patients with autosornal dominant polycystic kidney disease
51. Autosomal dominant polycystic kidney disease in the rat
52. Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease
53. Gender-dependent disease severity in autosomal polycystic kidney disease of rats
54. Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats
55. Azotemia and extrarenal manifestations in old female Han:SPRD (cy/+) rats
56. FITC-dextran as a probe for endosome function and localization in kidney
57. Megalin/gp330 mediates uptake of albumin in renal proximal tubule
58. Low density lipoprotein receptor-related protein and gp330 bind similar ligands,including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance
59. Receptor-mediated endocytosis in kidney proximal tubules: Recent advances and hypothesis
60. CIC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells
61. 3
62. A common molecular basis for three inherited kidney stone diseases
63. Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5)
64. In vivo adenovirus-mediated gene transfer into normal and cystic rat kidneys