Anti-HBV hairpin ribozyme-mediated cleavage of target RNA in vitro

World Journal of Gastroenterology

Volumn 8, Issue 1, 2002, Pages 91-94

  Song, Yu Hu ^a   Lin, Ju Sheng ^a   Liu, Nan Zhi ^a   Kong, Xin Juan ^a   Xie, Na ^a   Wang, Nan Xia ^a   Jin, You Xin ^a   Liang, Kuo Huan ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HEPATITIS B VIRUS RIBOZYME; ANTIVIRUS AGENT; DNA DIRECTED RNA POLYMERASE; RNA; UNCLASSIFIED DRUG; VIRUS VECTOR;

ARTICLE; CATALYSIS; COMPUTER SYSTEM; DENATURING GRADIENT GEL ELECTROPHORESIS; DRUG DESIGN; DRUG POTENCY; GENE STRUCTURE; GENE TARGETING; HEPATITIS B; HEPATITIS B VIRUS; IN VITRO STUDY; KINETICS; NONHUMAN; RECOMBINANT PLASMID; RNA CLEAVAGE; RNA PURIFICATION; VIRUS CORE; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

EID: 0036168435     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v8.i1.91     Document Type: Article

References (51)

1. Host factors in chronicity of hepatitis B virus infection and their significances in clinic
2. Hepatitis B
3. Hepatitis B: An important public health issue
4. Hepatitis B infection in China
5. Chronic hepatitis B virus infection in Asian countries
6. Expression of nuclear factor-κB in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus
7. HBV DNA distribution of hepatitis B virus in pancreas and liver of patients with cirrhosis
8. A five-year follow up survey of risk factor of viral hepatic cirrhosis
9. Cyclin D1 amplification is associated with HBV DNA intergration and pathology in human hepatocellular carcinoma
10. Expression of IGF-I, IGF-I receptor mRNA in hepatocellular carcinomas and adjacent nontumor tissue
11. Pathological significance of expression intrahepatic smooth muscle fiber in hepatitis B
12. Expression of HBsAg, HCV-Ag and AFP in liver cirrhosis and hepatocarcinoma
13. Hepatitis B virus in hepatocarcinogenesis
14. Hepatitis B virus and hepatocellular carcinoma
15. Preliminary results of Thymosin-a1 versus interferon-α-treatment in patient with HBeAg negative and serum HBV DNA positive chronic hepatitis B
16. Effect of adenine arabinoside monophosphate coupled to lactosaminated human serum albumin on duck hepatitis B virus
17. Effect on replication of hepatitis B virus by Chinese traditional medicine
18. Clinical analysis of the efficacy of interferon alpha treatment of hepatitis
19. Recently therapy for chronic hepatitis B virus by combined traditional Chinese and Western medicine
20. New antiviral agents for the therapy of chronic hepatitis B virus infection
21. Use of immunomodulatory therapy (other than interferon) for the treatment of chronic hepatitis B virus infection
22. Interferon monotherapy in chronic hepatitis B
23. Antiviral chemotherapy for the treatment of hepatitis B virus infections
24. Lamivudine for hepatitis B in clinical practice
25. Hepatitis B e antigen seroconversion: Effects of lamivudine alone or in combination with interferon alpha
26. Profound suppression of hepatitis B virus replication with lamivudine
27. Lamivudine. A review of its therapeutic potential in chronic hepatitis B
28. Chronic hepatitis B virus infection: Treatment strategies for the next millennium
29. Hepatitis B infection: Pathogenesis and management
30. Chinese medicinal herbs for chronic hepatitis B: A systematic review
31. Molecular anatomy and pathophysiologic implications of drug resistance in hepatitis B virus infection
32. Clinical potential of emerging new agents in hepatitis B
33. Combination chemotherapy for hepatitis B virus: The path forward?
34. Ribozymes and the anti-gene therapy: How a catalytic RNA can be used to inhibit gene function
35. Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template
36. Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells
37. Inhibition of CCR5-dependent HIV-1 infection by hairpin ribozyme gene therapy against CC-chemokine receptor 5
38. Retrovirally expressed anti-HIV ribozymes confer a selective survival advantage on CD4+ T cells in vitro
39. Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model
40. The antisense sequence of the HIV-1 TAR stem-loop structure covalently linked to the hairpin ribozyme enhances its catalytic activity against two artificial substrates
41. Design and anti-HIV-1 activity of hammerhead and hairpin ribozymes containing a stable loop
42. Gene therapy targeting cord blood-derived CD34+ cells from HIV-exposed infants: Preclinical studies
43. A potential therapeutic application of hairpin ribozymes: In vitro and in vivo studies of gene therapy for hepatitis C virus infection
44. Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes
45. Effect of specific connected ribozyme-mediated cleave on anti-HBV in vitro
46. A small catalytic oligoribonucleotide
47. Intracellular application of hairpin ribozyme genes against hepatitis B virus
48. Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus
49. Preparation and identification of activity of anti-HPV-6b/11E1 universal ribozyme-Rz1198 in vitro
50. Preparation and identification of hammerhead ribozyme in vitro against rat caspase-3 mRNA fragment
51. Activity identification of anti-caspase-3 mRNA hammerhead ribozyme in both cell-free condition, and BRL-3A cells