Aged F344 rats exhibit an increased proportion of dopamine agonist-excited striatal neurons

Neurobiology of Aging

Volumn 23, Issue 2, 2002, Pages 263-270

  Stanford, John A ^a,b   Gash, Clelland R ^a   Gerhardt, Greg A ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Aging; Basal ganglia; Dopamine; Electrophysiology; Freely moving; Multiunit; Striatum

Indexed keywords

APOMORPHINE; DEXAMPHETAMINE; DOPAMINE;

AGE; AGED; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; CELL ISOLATION; CONTROLLED STUDY; CORPUS STRIATUM; ELECTRODE; MALE; NERVE CELL STIMULATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; WAVEFORM;

AGING; ANIMALS; APOMORPHINE; DEXTROAMPHETAMINE; DOPAMINE AGONISTS; DOPAMINE UPTAKE INHIBITORS; ELECTRODES, IMPLANTED; ELECTROPHYSIOLOGY; MALE; NEOSTRIATUM; NEURONS; RATS; RATS, INBRED F344;

EID: 0036166997     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(01)00284-6     Document Type: Article

References (49)

1. Prevalence of parkinsonian signs and associated mortality in a community population of older people
2. Effects of intra-striatal GDNF on motor coordination and striatal electrophysiology in aged F344 rats
3. Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions
4. Aging reduces neostriatal responsiveness to N-methyl-D-aspartate and dopamine: An in vitro electrophysiological study
5. Extracellular glutamate levels increase with age in the lateral striatum: Potential involvement of presynaptic D-2 receptors
6. Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys
7. Selective alteration of mouse brain neurotransmitter release with age
8. In vivo electrochemical studies of dopamine diffusion and clearance in the striatum of young and aged Fischer-344 rats
9. Heterogeneous responses of neostriatal neurons to amphetamine in freely moving rats
10. Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey
11. Developmental and age-related alterations in rat brain presynaptic dopaminergic mechanisms
12. Decline in striatal dopamine D1 and D2 receptor activation in aged F344 rats
13. Effect of aging on concentrations of D2-receptor-containing neurons in the rat striatum
14. Amphetamine-induced excitations predominate in single neostriatal neurons showing motor-related activity
15. Amphetamine effects on striatal neurons: Implications for models of dopamine function
16. Striatal single-unit responses to amphetamine and neuroleptics in freely moving rats
17. Normal and drug-induced locomotor behavior in aging: Comparison to evoked DA release and tissue content in Fischer 344 rats
18. Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: An in vivo electrochemical study
19. Biochemical pathophysiology of Parkinson's disease
20. Aging and the nigrostriatal dopamine system: A nonhuman primate study
21. Multiple single unit recordings in the striatum of freely-moving animals: Effects of apomorphine and d-amphetamine in normal and unilateral 6-hydroxydopamine-lesioned rats
22. GABAergic circuits of the striatum
23. Age-related decreases in dopamine receptors in the caudate nucleus and putamen of the rhesus monkey (Macaca mulatta)
24. Neurophysiological and morphological alterations in caudate neurons in aged cats
25. Age-related decline in rat striatal dopamine metabolism is regionally homogeneous
26. Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals
27. Glutamate uptake impairment and neuronal damage in young and aged rats in vivo
28. Quantitative analysis of age-related dendritic changes in medium spiny I (MSI) striatal neurons of C57BL/6N mice
29. Loss of D2 receptors during aging is partially due to decreased levels of mRNA
30. Effect of low amphetamine doses on cardiac responses to emotional stress in aged rats
31. Iontophoresis in the neostriatum of awake, unrestrained rats: Differential effects of dopamine, glutamate and ascorbate on motor- and nonmotor-related neurons
32. Catecholamine synthesis in brain of aging rat
33. Dopamine-glutamate-GABA interactions and ageing: Studies in the striatum of the conscious rat
34. Stimulants and motor-related striatal neuronal activity
35. Differential effects of the optical isomers of amphetamine on neuronal activity in the reticular formation and caudate nucleus of the rat
36. Responses of neurons in dorsal striatum during amphetamine-induced focused stereotypy
37. Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness
38. Age-related alterations in monoamine release from rat striatum: An in vivo electrochemical study
39. Age-related changes in striatal function of freely-moving F344 rats
40. Biochemical and anatomical changes in basal ganglia of aging animals
41. Single unit activity in frontal cortex and caudate nucleus of young and old rats
42. Bilateral cortical ablations attenuate amphetamine-induced excitations of neostriatal motor-related neurons in freely-moving rats
43. Loss of paired-pulse facilitation at the corticostriatal synapse of the aged rat
44. Immobilization of rats modifies the response of striatal neurons to dexamphetamine
45. Differential decrease in the rate of dopamine synthesis in several dopaminergic neurons of aged rat brain
46. Low-dose amphetamine elevates movement-related firing of rat striatal neurons
47. Dopaminergic modulation of glutamate release in striatum measured by microdialysis
48. Compensations after lesions of central dopaminergic neurons: Some clinical and basic implications