Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with ΔE1, ΔE3 recombinant adenovirus vectors

Gene Therapy

Volumn 9, Issue 1, 2002, Pages 81-84

  Hirschowitz, E ^a   Hidalgo, G ^a   Doherty, D ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Adenovirus; COX 2; ERK; Non small cell lung cancer (NSCLC); PGE 2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOVIRUS VECTOR; APOPTOSIS INHIBITOR; CYCLOOXYGENASE 2; GREEN FLUORESCENT PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PSORALEN; RECOMBINANT INTERLEUKIN 1BETA; SN 50; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER CELL; CELL INVASION; CELL NUCLEUS TRANSPLANTATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GENE TRANSLOCATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPOPROTEIN SYNTHESIS; LUNG NON SMALL CELL CANCER; PLASMID; PRIORITY JOURNAL; PROTEIN INDUCTION; REPORTER GENE; TRANSGENE; TUMOR IMMUNITY; ULTRAVIOLET RADIATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT; WESTERN BLOTTING;

ADENOVIRIDAE;

ADENOVIRIDAE; CARCINOMA, NON-SMALL-CELL LUNG; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; ISOENZYMES; LUNG NEOPLASMS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TUMOR CELLS, CULTURED;

EID: 0036166707     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301621     Document Type: Article

References (27)

1. Cell receptors involved in adenovirus entry
2. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
3. Integrins and signal transduction pathways: The road taken
4. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
5. Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase
6. Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins
7. Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vector
8. E1(-)E4(+) adenoviral gene transfer vectors function as a 'pro-life' signal to promote survival of primary human endothelial cells
9. Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kappaB
10. Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway
11. High adenoviral loads stimulate NF kappaB-dependent gene expression in human vascular smooth muscle cells
12. Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta
13. Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid
14. Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2
15. The role of cyclooxygenases in inflammation, cancer, and development
16. Molecular pathology of cyclooxygenase-2 in neoplasia
17. Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells
18. Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells
19. Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas
20. Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44
21. K-ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B 1
22. Immunosuppressive factors in human cancer
23. Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: Up-regulation of interleukin 10 and down-regulation of interleukin 12 production
24. Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production
25. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production
26. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis
27. Construction of adenovirus vectors through Crelox recombination