Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: Cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines

International Immunology

Volumn 14, Issue 2, 2002, Pages 131-138

  Maron, Ruth ^a   Slavin, Anthony J ^a   Hoffmann, Ethan ^a   Komagata, Yoshinori ^a   Weiner, Howard L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anti inflammatory cytokines; Copolymer 1; Experimental allergic encephalomyelitis; Myelin basic protein; Oral tolerance; Transforming growth factor

Indexed keywords

COLLAGEN; COPOLYMER; CYTOKINE; GAMMA INTERFERON; GLATIRAMER; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LIGAND; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; OVALBUMIN; PEPTIDE; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTHRITIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERANCE; FEMALE; IMMUNIZATION; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0036160990     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/14.2.131     Document Type: Article

References (26)

1. Oral tolerance: Mechanisms and therapeutic applications
2. + cells mediate active suppression
3. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
4. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
5. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy
6. Direct measurement of anergy of antigen-specific T cells following oral tolerance induction
7. Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide
8. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial
9. In vivo and in vitro immunological cross-reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis
10. Cross-reactions and specificities of monoclonal antibodies against myelin basic protein and against the synthetic copolymer 1
11. Promiscuous binding of synthetic copolymer 1 to purified HLA-DR molecules
12. Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking
13. T suppressor hybridomas and interleukin-2-dependent lines induced by copolymer 1 or by spinal cord homgenate down-regulate experimental allergic encephalomyelitis
14. h2 type induced by copolymer 1
15. Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis
16. Immunomodulation of experimental autoimmune encephalomyelitis by oral administration of copolymer 1
17. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
18. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species
19. h3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis
20. Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones
21. Mechanisms of action of glatiramer acetate in multiple sclerosis
22. Human and murine CD4 T cell reactivity to a complex antigen: Recognition of the synthetic random polypeptide glatiramer acetate
23. Mechanisms of immunomodulation by glatiramer acetate
24. h3 immune-deviation
25. A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T cell proliferative responses to major and minor histocompatibility antigens in vitro and capacity to prevent murine graft-versus-host disease in vivo
26. Copolymer 1 inhibits experimental autoimmune uveoretinitis