Protein kinase c-α mediates cigarette smoke extract- and complement factor 5a-stimulated interleukin-8 release in human bronchial epithelial cells

Journal of Investigative Medicine

Volumn 50, Issue 1, 2002, Pages 46-53

  Kashyap, Ravindra ^a   Floreani, Anthony A ^a   Heires, Arthur J ^a   Sanderson, Sam D ^a   Wyatt, Todd A ^a  

^a NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Airway epithelium; C5a; Cigarette smoke; IL 8; PKC

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; CALCIMYCIN; CALCIUM IONOPHORE; CALPHOSTIN C; CHOLESTEROL 3 SULFATE; CHOLESTEROL DERIVATIVE; CIGARETTE SMOKE; COMPLEMENT COMPONENT C5A; INTERLEUKIN 8; ISOPROTEIN; LY 363196; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ALPHA INHIBITOR; PROTEIN KINASE C BETA INHIBITOR; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CALCIUM CELL LEVEL; COMPLEMENT ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; ENZYME SPECIFICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; IMMUNOSTIMULATION; INCUBATION TIME; INFLAMMATION; SMOKING;

BRONCHUS;

EID: 0036155794     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: 10.2310/6650.2002.33517     Document Type: Article

References (34)

1. Occupational and environmental lung diseases. An overview
2. Oxidants/antioxidants and COPD
3. Cigarette smoke exposure produces more evidence of emphysema in B6C3F1 mice than in F344 rats
4. Bacterial infection and the pathogenesis of COPD
5. The bronchial epithelium: More than a mechanical protection. The role of bronchial epithelial cells in defective healing has been determined
6. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma
7. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells
8. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: Enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke
9. Acetaldehyde-stimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes
10. Stimulation of protein kinase C activity by tumor necrosis factor alpha in bovine bronchial epithelial cells
11. A technique to harvest viable tracheobronchial epithelial cells from living human donors
12. Protein kinase C activation is required for cigarette smoke-enhanced C5a-mediated release of interleukin-8 in human bronchial epithelial cells
13. Development of C5a receptor antagonists. Differential loss of functional responses
14. Identification of PKC-isoform-specific biological actions using pharmacological approaches
15. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
16. Smoking and chronic obstructive pulmonary disease
17. The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage
18. Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters
19. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils
20. Interleukin-8 induces neutrophil transendothelial migration
21. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines
22. Anti-inflammatory effects of triptolide in human bronchial epithelial cells
23. Protein kinase C activation is required for cigarette smoke-enhanced C5a-mediated release of interleukin-8 in human bronchial epithelial cells
24. 15-HETE-substituted diglycerides selectively regulate PKC isotypes in human tracheal epithelial cells
25. Differential activation of PKC-delta and -zeta by alpha 1-adrenergic stimulation in human airway epithelial cells
26. The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: Synergy with interleukin-2 and modulation of interleukin-2Rgamma chain expression
27. Inhibition of the arachidonic acid pathway prevents induction of IL-8 mRNA by phorbol ester and changes the release of IL-8 from HL 60 cells: Differential inhibition of induced expression of IL-8, TNF-alpha, IL-1 alpha, and IL-1 beta
28. Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kappaB activation
29. Induction and secretion of the chemokines interleukin-8 and monocyte chemotactic protein-1 in human immature leukemia cell lines
30. Lipopolysaccharide-induced NF-kappaB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent
31. IL-17-induced cytokine release in human bronchial epithelial cells in vitro: Role of mitogen-activated protein (MAP) kinases
32. Pseudomonas pyocyanin increases interleukin-8 expression by human airway epithelial cells
33. Induction of interleukin-8 by ozone is mediated by tyrosine kinase and protein kinase A, but not by protein kinase C
34. Calcium and protein kinase C dependency of lipoxygenase-derived neutrophil chemotactic activity release from bronchial epithelial cells