Docosapentaenoic acid (22:5, n-3), an elongation metabolite of eicosapentaenoic acid (20:5, n-3), is a potent stimulator of endothelial cell migration on pretreatment in vitro

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 54, Issue 5, 1996, Pages 319-325

  Kanayasu Toyoda, Toshie ^a   Morita, Ikuo ^a   Murota, Sei Itsu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; ICOSAPENTAENOIC ACID; INDOMETACIN; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CELL MIGRATION; CONTROLLED STUDY; COW; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0030035726     PISSN: 09523278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-3278(96)90045-9     Document Type: Article

References (33)

1. Bondjers G., Brattsand R., Bylock A., Hansson G. K., Björkerud S. Endothelial integrity and atherogenesis in rabbit with moderate hypercholesterolaemia. Artery 1977; 3: 395-401.
2. Gabbiani G., Elemer G., Guelpa C., Vallotton M. B., Bandonnel M.-C., Hüttner I. Morphologic and functional changes of the aortic intima during experimental hypertension. Am J Pathol 1979; 96: 399-422.
3. Quinn M. T., Parthasarathy S., Steinberg D. Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein. Proc Natl Acad Sci USA 1985; 82: 5949-5953.
4. Dyerberg J., Bang H. O., Stoffersen E., Moncada S., Vane J. R. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978; ii: 117-119.
5. Kromhout D., Bosschieter E. B., Coulander C. L. The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 1985; 312: 1205-1209.
6. Phillipson B. E., Rothcock D. W., Connor W. E., Harris W. S., Illingworth D. R. Reduction of plasma lipids, lipoproteins and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 1985; 312: 1210-1216.
7. Lee T. H., Hoover R. L., Williams J. D. et al. Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 1985; 312: 1217-1224.
8. Illingworth D. R., Harriss W. S., Connor W. E. Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans. Arteriosclerosis 1984; 4: 270-275.
9. 3 and icosapentaenoic acid as potential anti-thrombotic substances. Proc Natl Acad Sci USA 1979; 76: 5919-5923.
10. Needleman P., Whitaker M. O., Wyche A., Watters K., Sprecher H., Raz A. Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: pharmacologic basis for a therapeutic approach. Prostaglandins 1980; 19: 165-181.
11. Dyerberg J., Jørgenson K. A. The effect of arachidonic and eicosapentaenoic acid on the synthesis of prostacyclin-like material in human umbilical vasculature. Artery 1980; 8: 12-17.
12. 2-like substance production by rat aorta. Prostaglandins 1982; 23: 557-567.
13. Morita I., Saito Y., Chang W. C., Murota S. Effects of purified eicosapentaenoic acid on arachidonic acid metabolism in cultured murine aortic smooth muscle cells, vessel walls and platelets. Lipids 1983; 18: 42-49.
14. Spector A. A., Kaduce T. L., Figard P. H., Norton K. C., Hoak J. C., Czervionke R. L. Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells. J Lipid Res 1983; 24: 1595-1604.
15. Hadjiagapiou C., Kaduce T. L., Spector A. A. Eicosapentaenoic acid utilization by bovine aortic endothelial cells: effects on prostacyclin production. Biochim Biophys Acta 1986; 875: 369-381.
16. Kanayasu T., Morita I., Nakao-Hayashi J., Ito H., Murota S. Enhancement of migration in bovine endothelial cells by eicosapentaenoic acid pretreatment. Atherosclerosis 1991; 87: 57-64.
17. Morita I., Kanayasu T., Murota S. Kallikrein stimulates prostacyclin production in bovine vascular endothelial cells. Biochim Biophys Acta 1984; 792: 304-309.
18. Ross R. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 1971; 50: 172-186.
19. Bligh E. G., Dyer W. J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959; 37: 911-917.
20. Marangoni F., Angeli M. T., Colli S. et al. Changes of n-3 and n-6 fatty acids and circulating cells of normal subjects, after prolonged administration of 20:5 (EPA) and 20:6 (DHA) ethyl esters and prolonged washout. Biochim Biophys Acta 1993; 1210: 55-62.
21. 2+-catalyzed-oxidative modification. Biochem Biophys Res Commun 1991; 175: 61-67.
22. von Schack C., Weber P. C. Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. J Clin Invest 1985; 76: 2446-2450.
23. Kanayasu-Toyoda T., Morita I., Hibino H., Nakao-Hayashi J., Ito H., Murota S. Eicosapentaenoic acid abolishes the proatherogenic effects of cholesterol: effects on migration of bovine smooth muscle and endothelial cells in vitro. Prostaglandins Leukot Essent Fatty Acids 1993; 48: 463-468.
24. Garcia M. C., Sprecher H., Rosenthal M. D. Chain elongation of polyunsaturated fatty acids by vascular endothelial cells: studies with arachidonate analogues. Lipids 1990; 25: 211-215.
25. 4 desaturation of docosatetraenoate (22:4 (n-6)) and docosapentaenoate (22:5 (n-3)) by human cells in culture. Biochim Biophys Acta 1991; 1083: 29-36.
26. Voss A., Reinhart M., Sankarappa S., Sprecher H. The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. J Biol Chem 1991; 266: 19995-20000.
27. Hyman B. T., Spector A. A. Accumulation of n-3 polyunsaturated fatty acids cultured human Y-79 retinoblastoma cells. J Neurochem 1981; 37: 60-69.
28. Yorek M. A., Bohnker R. R., Dudley D. T., Spector A. A. Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. Biochim Biophys Acta 1984; 795: 277-285.
29. Hodgson J. M., Wahlqvist M. L., Boxall J. A., Balazs N. D. Can linoleic acid contribute to coronary artery disease? Am J Clin Nutr 1993: 58: 228-234.
30. Bates E. J., Ferrante A., Harvey D. P., Poulos A. Polyunsaturated fatty acids increase neutrophil adherence and integrin receptor expression. J Leukoc Biol 1993; 53: 420-426.
31. Ferrante A., Goh D., Harvey D. P. et al. Neutrophil migration inhibitory properties of polyunsaturated fatty acids. The role of fatty acid structure, metabolism and possible second messenger systems. J Clin Invest 1994; 93: 1063-1070.
32. 2 activity. J Biol Chem 1994; 269: 3219-3225.
33. Bornfeldt K. E., Raines E. W., Nakano T., Graves L. M., Krebs E. G., Ross R. Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest 1994; 93: 1266-1274.