Structure-dependent induction of CYP1A by polychlorinated biphenyls in hepatocytes of cynomolgus monkeys (Macaca fascicularis)

Toxicology and Applied Pharmacology

Volumn 155, Issue 1, 1999, Pages 13-23

  Van Der Burght, Aafje S A M ^a   Clijsters, Peter J ^a   Horbach, G Jean ^a   Andersson, Patrik L ^b   Tysklind, Mats ^b   Van Den Berg, Martin ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BIOLOGICAL MARKER; CYTOCHROME P450 ISOENZYME; POLYCHLORINATED BIPHENYL; RESORUFIN DERIVATIVE;

ANIMAL TISSUE; ARTICLE; DEALKYLATION; ENZYME INDUCTION; LIVER CELL; MACACA; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; STRUCTURE ACTIVITY RELATION;

ANIMALIA; AVES; MACACA; MACACA FASCICULARIS; PRIMATES; RODENTIA;

EID: 0032995153     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8606     Document Type: Article

References (57)

1. Ahlborg U. G., Becking G. C., Birnbaum L. S., Brouwer A., Derks H. J. G. M., Feeley M., Golor G., Hanberg A., Larsen J. C., Liem A. K. D., Safe S. H., Schlatter C., Waern F., Younes M., Yrjanheikki E. Toxic equivalency factors for dioxin-like PCBs. Chemospere. 28:1994;1049-1067.
2. Allen J. R., Carstens L. A., Barsotti D. A. Residual effects of short-term, low level exposure of non-human primates to polychlorinated biphenyls. Toxicol. Appl. Pharmacol. 30:1974;440.
3. Andersson P., Haglund P., Rappe C., Tysklind M. Ultraviolet absorbtion characteristics and calculated semi-empirical parameters as chemical descriptors in multivariate modelling of polychlorinated biphenyls. J. Chemometrics. 10:1996;171-185.
4. Andersson P. L., Haglund P., Tysklind M. Ultraviolet absorbtion spectra of all 209 polychlorinated biphenyls evaluated by principle component analysis. Fresenius J. Anal. Chem. 357:1997a;1088-1092.
5. Andersson P. L., Haglund P., Tysklind M. The internal barriers of rotation for the 209 polychlorinated biphenyls. Environ. Sci. Poll. Res. 4:1997b;75-81.
6. Ballschmiter K., Zell M. Analysis of polychlorinated biphenyls (PCBs) by glass capillary gas chromatography of technical Aroclor- and Clophen-PCB mixtures. Fresenius Z. Anal. Chem. 302:1980;20.
7. Bosveld, A. T. C. 1995, Effects of polychlorinated aromatic hydrocarbons on piscivorous avian wildlife, Utrecht, The Netherlands.
8. Bouwman C. A., Fase K., Waalkens-Berendsen I., Smits-van Prooije A., Seinen W., Van den Berg M. Cytochrome P450 induction in weanling and adult rats exposed to PCB 126, PCB 118, PCB 153 and 2,3,4,7,8-PnCDF. Organohalogen Compd. 29:1996;184-189.
9. Bouwman C. A., Seinen W., Koppe J. G., Van den Berg M. Effects of 2,3,7,8-tetrachorodibenzo-p. Toxicology. 75:1992;109-120.
10. Bradford M. M. A rapid and sensitive method for quantification of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
11. Brouwer A. Inhibition of thyroid hormone transport in plasma of rats by polychlorinated biphenyls. Arch. Toxicol. Suppl. 13:1989;440-445.
12. Bullock P., Pearce R., Draper A., Podval J., Bracken W., Veltman J., Thomas P., Parkinson A. Induction of liver microsomal cytochrome P450 in cynomolgus monkeys. Drug Metab. Dispos. 23:1995;736-748.
13. Burke M. D., Mayer R. T. Ethoxyresorufin: Direct fluometric assay of a microsomalO. Drug Metab. Dispos. 2:1974;583-588.
14. Burke M. D., Thompson S., Weaver R. J., Wolf C. R., Mayer R. T. Cytochrome P450 specificities of alkoxyresorufinO. Biochem. Pharmacol. 48:1994;923-936.
15. Connor K., Safe S., Jefcoate C. R., Larsen M. Structure dependent induction of CYP2B by polychlorinated biphenyls congeners in female Sprague-Dawley rats. Biochem. Pharmacol. 50:1995;1913-1920.
16. De Jongh J., DeVito M., Nieboer R., Birnbaum L. S., Van den Berg M. Induction of cytochrome P450 isoenzymes after toxicokinetic interactions between 2,3,7,8-tetrachlorodibenzo-p. Fundam. Appl. Toxicol. 25:1995;264-270.
17. Denison M. S., Wilkinson C. F., Okey A. B. Ah receptor for 2,3,7,8-tetra-chlorodibenzo-p. Chemosphere. 15:1986;1665-1672.
18. Edwards R. J., Murray B. P., Murray S., Schutz T., Neubert D., Gant T. W., Thorgeirsson S. S., Boobis A. R., Davies D. S. Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human. Carcinogenesis. 15:1994;829-836.
19. Hahn M. E., Chandran K. Uroporphyrin accumulation associated with cytochrome P4501A induction in fish hepatoma cells exposed to aryl hydrocarbon receptor agonists, including 2,3,7,8-tetrachlorodibenzo-p. Arch. Biochem. Biophys. 329:1996a;163-174.
20. Hahn M. E., Lamb T., Schultz M. E., Smolowitz R. M., Stegeman J. Cytochrome P4501A induction and inhibition by 3,3′,4,4′-tetrachloro-biphenyl in anAh. J. Aquat. Toxicol. 26:1993;185-208.
21. Hahn M. E., Woodward B. L., Stegeman J. J., Kennedy S. W. Rapid assessment of induced cytochrome P4501A protein and catalitic activity in fish hepatoma cells grown in multiwell plates: Response to TCDD, TCDF, and two planar PCBs. Environ. Toxicol. Chem. 15:1996b;582-591.
22. Hori S., Obana H., Kashimoto T., Otake T., Nishimura N., Ikegami N., Kunita N., Uda H. Effect of polychlorinated biphenyls and polychlorinated quarter-phenyls in cynomolgus monkeys (Macaca fascicularis. Toxicology. 24:1982;123-139.
23. Jacqz E., Billante C., Moysan F., Mathieu H. The non-human primate: A possible model for human genetically determined polymorphisms in oxidative drug metabolism. Mol. Pharmacol. 34:1988;215-217.
24. Kennedy S. W., Lorenzen A., James C. A. A rapid and sensitive cell culture bioassay for measuring ethoxyresorufin-O. Chemosphere. 27:1993;367-373.
25. Kennedy S. W., Lorenzen A., Norstrom R. J. Chicken embryo hepatocytes bioassay for measuring cytochrome P4501A-based 2,3,7,8-tetra-chlorodibenzo-p. Environ. Sci. Technol. 30:1996;706-715.
26. Kimbrough R. D., Jensen A. A. Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products. 1989;Elsevier, Amsterdam.
27. Komori M., Kikuchi O., Kitada M., Kamataki T. Molecular cloning of monkey P450 1A1 cDNA and expression in yeast. Biochim. Biophys. Acta. 1131:1992;23-29.
28. Lee Q., Fantel A., Juchau M. Human embryonic cytochrome P450s:p. Biochem. Pharmacol. 42:1991;2377-2385.
29. McFarland V. A., Clarke J. U. Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: Considerations for a congener-specific analysis. Environ. Health Perspect. 81:1989;225-239.
30. Mennes W. C., van Holsteijn C. W. M., Timmerman A., Noordhoek J., Blaauboer B. J. Biotransformation of scoparone used to monitor changes in cytochrome P450 activities in primary hepatocyte cultures derived from rats, hamsters and monkeys. Biochem. Pharmacol. 41:1991;1203-1208.
31. NATO/CCMS, North Atlantic Treaty Organization/Committee on the Challenges of Modern Society, 1988, Internationally Toxicity Equivalency Factor Method of Risk Assessment for Complex Mixtures of Dioxins and Related Compounds.
32. Nerurkar P., Park S., Thomas P., Nims R., Lubet R. Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochrome P450 1A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol. 46:1993;933-943.
33. Parkinson A., Safe S. H., Robertson L. W., Thomas P. E., Ryan D. E., Reik L. M., Levin W. Immunochemical quantitation of cytochrome P-450 isoenzymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. J. Biol. Chem. 258:1983;5967-5976.
34. Peterson R. D., Theobald H. M., Kimmel G. L. Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons. Crit. Rev. Toxicol. 23:1993;283-335.
35. Rappe C., Buser H. G., Bosshardt H. P. Dioxins, dibenzofurans and other polychlorinated aromatics: Production, use formation and destruction. Ann. NY Acad. Sci. 320:1979;1-18.
36. Rodman L. E., Shedlovsky S. L., Swim A. T., Robertson L. W. Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture. Arch. Biochem. Biophys. 275:1989;252-262.
37. Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p. Crit. CRC Rev. Toxicol. 21:1990;51-88.
38. Safe S. H. Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses and implications for risk assessment. CRC Crit. Rev. Toxicol. 24:1994;87-149.
39. Sanderson J. T., Aarts J. M. M. J. G., Brouwer A., Froese K. L., Denison M. S., Giesy J. P. Comparison ofAhO. Toxicol. Appl. Pharmacol. 137:1996;316-325.
40. Sawyer T., Safe S. PCB isomers and congeners: Induction of aryl hydrocarbon hydroxylase and ethoxyresorufino. Toxicol. Lett. 13:1982;87-94.
41. Schuetz E. G., Wrighton S. A., Safe S. H., Guzelian P. S. Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture andin vivo. Biochemistry. 25:1986;1124-1133.
42. Schulte E., Malisch R. Calculation of the real PCB content in environmental samples I. Investigation of the composition of two technical PCB mixtures. Fresenius Z. Anal. Chem. 314:1983;545-551.
43. Seegal R. F., Bush B., Shain W. Lightly chlorinatedortho. Toxicol. Appl. Pharmacol. 106:1990;136-144.
44. Sharer J. E., Shipley L. A., Vandenbranden M. R., Binkley S. N., Wrightin S. A. Comparisons of phase I and phase IIin vitro. Drug Metab. Dispos. 23:1995;1231-1241.
45. Silberhorn E. M., Glauert H. P., Robertson L. W. Carcinogenity of polychlorinated biphenyls: PCBs and PBBs. CRC Crit. Rev. Toxicol. 20:1990;439-496.
46. Truelove J., Grant D., Mes J., Tryphonas L., Zawidzka Z. Polychlorinated biphenyl toxicity in the pregnant cynomolgus monkey: A pilot study. Arch. Environ. Contam. Toxicol. 11:1982;583-588.
47. Tysklind M., Andersson P., Haglund P., Bavel van B., Rappe C. Selection of polychlorinated biphenyls for use in quantitative structure activity modelling. SAR & QSAR Environ. Res. 4:1995a;11-19.
48. Tysklind M., Bosveld A. T. C., Anderson P., Verhallen E., Sinnige T., Seinen W., Rappe C., Berg van den M. Inhibition of ethoxyresorufin-Op. Environ. Sci. Pollut. Res. 2:1995b;211-216.
49. Tysklind M., Lundgren K., Rappe C., Eriksson L., Jonsson J., Sjöström M. Multivariate quantitative structure-activity relationships for polychlorinated dibenzo-p. Environ. Toxicol. Chem. 12:1993;659-672.
50. Tysklind M., Tillitt D., Eriksson L., Lundgren K., Rappe C. A toxic equivalency factor scale for polychlorinated dibenzofurans. Fundam. Appl. Toxicol. 22:1994;277-285.
51. Van den Berg M., Birnbaum L. S., Bosveld A. T. C., Brunström B., Cook Ph., Feeley M., Giesy J. P., Hanberg A., Hasegawa R., Kennedy S. W., Kubiak T., Larsen J. C., Van Leeuwen F. X. R., Liem A. K. D., Nolt C., Peterson R. E., Poellinger L., Safe S., Schrenk D., Tillitt D., Tysklind M., Younes M., Wærn F., Zacharewski T. Toxic Equivalency Factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Env. Health Perspect. 106:1998;775-792.
52. Van der Burght A. S. A. M., Kreikamp A. P., Horbach G. J., Seinen W., Van den Berg M. Characterization of CYP1A in hepatocytes of cynomolgus monkeys (Macaca fascicularis. Arch. Toxicol. 72:1998;630-636.
53. Waalkens-Berendsen I., Smits-van Prooije A., Bouwman C. A., Van den Berg M. Reproductive effects in F1-generation rats perinatally exposed to PCB 126, PCB 118, PCB 153 and 2,3,4,7,8-PnCDF. Organohalogen Compond. 29:1996;122-125.
54. Waxman J. W., Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression. Biochem. J. 281:1992;577-592.
55. Weaver R. J., Thompson S., Smith G., Dickins M., Elcombe C. R., Mayers R. T., Burke M. D. A comparative study of constitutive and induced alkoxyresorufin-oMacaca fascicularis. Biochem. Pharmacol. 47:1994;763-773.
56. Wold S., Albano C., Dunn W. J. III, Edlund U., Esbensen K., Geladi P., Hellberg S., Johansson E., Lindgren W., Sjöström M. Multivariate data analysis in chemistry. Chemometrics: Mathematics and Statistics in Chemistry. NATO ASI Series C138. 1984;Riedel, Dortdrecht. p. 4-96.
57. Yao C., Panigrahi B., Safe S. Utilization of cultured chick embryo hepatocytes asin vitro. Chemosphere. 21:1990;1007-1016.