Protein ubiquitin is an immunophilin

Therapeutic Drug Monitoring

Volumn 24, Issue 1, 2002, Pages 32-35

  Davis, Diane L ^a   Soldin, Steven J ^a  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Calcineurin phosphatase; Immunophilin; Sirolimus; Tacrolimus; Ubiquitin

Indexed keywords

CALCINEURIN PHOSPHATASE; CYCLOPHILIN; CYCLOSPORIN; FK 506 BINDING PROTEIN; IMMUNOPHILIN; INTERLEUKIN 2; PHOSPHATASE; RAPAMYCIN; TACROLIMUS; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CATTLE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; ISOELECTRIC FOCUSING; LEUKEMIA CELL LINE; MASS SPECTROMETRY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; T LYMPHOCYTE;

HUMANS; IMMUNOPHILINS; INTERLEUKIN-2; JURKAT CELLS; MOLECULAR WEIGHT; PROTEIN BINDING; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; T-LYMPHOCYTES; UBIQUITIN; ULTRACENTRIFUGATION;

EID: 0036148771     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200202000-00006     Document Type: Conference Paper

References (27)

1. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity
2. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A
3. Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells
4. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
5. Immunophilin receptors for immunosuppressive drugs
6. Chemistry and biology of the immunophilins and their immunosuppressive ligands
7. Immunophilins: Their properties and their potential role in therapeutic drug monitoring
8. Purification and characterization of cyclosporine and FK-506 binding proteins from a human T-helper cell line
9. Identification of a 37 kDa tacrolimus, sirolimus and cyclosporine binding immunophilin possessing glyceraldehyde 3-phosphate dehydrogenase activity isolated from the Jurkat T cell line
10. Identification of a 14 kDa FK506/rapamycin binding immunophilin from calf thymus
11. Identification of ubiquitin as an immunophilin
12. Cyclophilin: A specific cytosolic binding protein for cyclosporin A
13. A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase
14. The human ubiquitin multigene family: Some genes contain multiple directly repeated ubiquitin coding sequences
15. The large-scale purification of ubiquitin from human erythrocytes
16. Ubiquitin system: Selectivity and timing of protein destruction
17. Structure of ubiquitin refined at 1.8 A resolution
18. The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation
19. Biochemical characterization of the minor immunophilins
20. Whole-blood calcineurin activity is not predicted by cyclosporine blood concentration in renal transplant recipients
21. Cell surface molecule associated with lymphocyte homing is a ubiquitinated branched-chain glycoprotein
22. Activation-induced ubiquitination of the T cell antigen receptor
23. Structure and functions of the 20S and 26S proteasomes
24. Signal transduction through NF-κB
25. The ubiquitin-proteasome system and endocytosis