NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCζ

European Journal of Immunology

Volumn 32, Issue 1, 2002, Pages 136-143

  Kronfeld, Ilana ^a   Kazimirsky, Gila ^a   Gelfand, Erwin W ^b   Brodie, Chaya ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Apoptosis; B lymphocyte; Nerve growth factor; PI3 kinase; PKC

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTISENSE OLIGONUCLEOTIDE; FAS ANTIGEN; IMMUNOGLOBULIN M; LYMPHOCYTE RECEPTOR; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR ANTIBODY; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIC FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ZETA; PROTEIN P75; PROTEIN TYROSINE KINASE INHIBITOR; WORTMANNIN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CANCER CELL CULTURE; CELL MEMBRANE; CELL NUCLEUS; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; GENE TRANSLOCATION; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE FUNCTION; NEUROPROTECTION; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; APOPTOSIS; B-LYMPHOCYTES; CARBAZOLES; CHROMONES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; IMMUNOGLOBULIN M; ISOENZYMES; MORPHOLINES; NERVE GROWTH FACTOR; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; RECEPTOR, TRKA; TUMOR CELLS, CULTURED;

EID: 0036148547     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200201)32:1<136::AID-IMMU136>3.0.CO;2-T     Document Type: Article

References (58)

1. Negative selection of human germinal center C cells by prolonged BCR cross-linking
2. Antigen-induced B-cell death and elimination during germinal-center immune responses
3. Soluble antigen can cause enhanced apoptosis of germinal-center B cells
4. Rescue from anti-IgM-induced programmed cell death by the B cell surface proteins CD20 and CD40
5. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
6. A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death
7. Platelet-activating factor abrogates apoptosis induced by cross-linking of the surface IgM receptor in a human B lymphoblastoid cell line
8. CD40 and adenosine A2 receptor agonist-cyclic adenosine monophosphate rescue B-cell antigen receptor-induced apoptosis through independent pathways and converge to prevent caspase activation
9. Prevention of anti-IgM-induced apoptosis accompanying G1 arrest in B lymphoma cells overexpressing dominant-negative mutant form of c-Jun N-terminal kinase 1
10. CD40-triggered protein tyrosine phosphorylation on Vav and on phosphatidylinositol 3-kinase correlates with survival of the Ramos-Burkitt lymphoma B cell line
11. Protein kinase C-alpha is essential for Ramos-BL B cell survival
12. Trophic factors and neuronal survival
13. The nerve growth factor: 35 years later
14. The expression localization and functional significance of beta-nerve growth factor in the central nervous system
15. Mast cell increase in tissues of neonatal rats injected with the nerve growth factor
16. Expression of functional trk protooncogene in human monocytes
17. Functional NGF receptors on human B lymphocytes: Interaction with IL-2
18. Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk
19. Nerve growth factor induces growth and differentiation of human B lymphocytes
20. Regulation of immunoglobulin production by nerve growth factor: Comparison with anti-CD40
21. Nerve growth factor inhibits immunoglobulin production by but not proliferation of human plasma cell lines
22. Nerve growth-factor and anti-CD40 provide opposite signals for the production of IgE in interleukin-4-treated lymphocytes
23. Nerve growth factor is an autocrine survival factor for memory B lymphocytes
24. The p75 neurotrophin receptor
25. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
26. Differential regulatory effects of cAMP-elevating agents on human normal and neoplastic B cell functional response following ligation of surface immunoglobulin and CD40
27. K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors
28. Serine/threonine protein kinases and apoptosis
29. Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells
30. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
31. Neurotrophins: Signals between the nervous and immune system
32. Neurotrophin signal transduction in the nervous system
33. Nerve growth factor prevents apoptosis of rat peritoneal mast cells through the trk proto-oncogene receptor
34. Nerve growth factor is an autocrine factor essential for the survival of macrophages infected with HIV
35. Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase
36. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
37. Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway
38. Nerve growth factor induces activation of MAP-kinase and p90rsk in human B lymphocytes
39. Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells
40. Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: Relationship to differentiation and survival of PC12 cells
41. Nuclear translocation of protein kinase C-alpha and -zeta isoforms in HL-60 cells induced to differentiate along the granulocytic lineage by all-trans retinoic acid
42. Nuclear translocation of PKZ zeta during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3-kinase
43. A functional role for mitochondrial protein kinase C-alpha in Bcl2 phosphorylation and suppression of apoptosis
44. Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation
45. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
46. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells
47. Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis
48. Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth fctor-1-binding protein-3
49. Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-zeta in bacterial lipopolysaccharide-treated human monocytes
50. Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
51. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
52. Ly294002-mediated inhibition of phosphatidylinositol 3-kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos-Burkitt lymphoma B cells
53. CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL
54. Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells
55. Phosphatidylinositol-3-kinase activity is required for the anti-IgM-mediated growth inhibition of a human B-lymphoma cell line
56. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
57. A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation
58. Bcl-Xshort is elevated following severe global ischemia in rat brains