Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs

American Journal of Respiratory and Critical Care Medicine

Volumn 165, Issue 1, 2002, Pages 27-33

  Suzuki, Ryoichi ^a   Freed, Arthur N ^a,b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Airway hyperreactivity; Dry air challenge; Eicosanoid mediator; Heparin; Hyperventilation induced bronchoconstriction; Peripheral airway resistance

Indexed keywords

HEPARIN; ICOSANOID; LEUKOTRIENE; PROSTAGLANDIN;

AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; DOG; EOSINOPHIL; FIBEROPTIC BRONCHOSCOPY; HYPERVENTILATION; IMMUNE RESPONSE; INFLAMMATION; LUNG LAVAGE; MALE; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL;

EID: 0036143786     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.165.1.2010084     Document Type: Article

References (61)

1. Heterogeneity of mechanisms in exercise induced asthma
2. Pulmonary responses of asthmatic and normal subjects to different temperature and humidity conditions in an environmental chamber
3. Airway effects of respiratory heat loss in normal subjects
4. Heat and water flux in the intrathoracic airways and exercise-induced asthma
5. Postexertional airway rewarming and thermally induced asthma
6. Airway inflammation and occurrence of delayed bronchoconstriction in exercise-induced asthma
7. Late bronchial response and increase in methacholine hyperresponsiveness after exercise and distilled water challenge in atopic subjects with asthma with dual asthmatic response to allergen inhalation
8. Factors predisposing to exercise-induced late asthmatic responses
9. Exercise-induced late asthmatic reactions with neutrophil chemotactic activity
10. Immediate and late asthmatic responses induced by exercise in patients with reversible airflow limitation
11. Airway responsiveness to allergen is increased 24 hours after exercise challenge
12. Late asthmatic response in exercise-induced asthma
13. Immediate and delayed bronchconstriction after exercise in patients with asthma
14. Occurrence of a late response to exercise in asthmatic children: Multiple regression approach using time-matched baseline and histamine control days
15. Dry air-induced late phase responses in the canine lung periphery
16. Experimental models of exercise-induced asthma
17. Peripheral airways responsiveness to cool, dry air in normal and asthmatic individuals
18. Regulation of the inducible cyclo-oxygenase pathway in human cultured airway epithelial (A549) cells by nitric oxide
19. Airflow-induced bronchoconstriction: Role of epithelium and eicosanoid mediators
20. Eicosanoids modulate hyperpnea-induced bronchoconstriction in canine peripheral airways
21. Mucosal-injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction
22. Time course of the protective effect of inhaled heparin on exercise-induced asthma
23. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin
24. Prevention of exercise-induced bronchoconstriction by inhaled low-molecular weight heparin
25. Heparin inhibits eicosanoid metabolism and hyperventilation-induced bronchoconstriction in dogs
26. Heparin modulates migration of human peripheral blood mononuclear cells and neutrophils
27. Heparin inhibits leukocyte rolling in pial vessels and attenuates inflammatory changes in a rat model of experimental bacterial meningitis
28. The effect of inhaled heparin and related gycosaminoglycans on allergen-induced eosinophil infiltration in guinea-pigs
29. Effect of heparin and a low-molecular weight heparinoid on PAF-induced airway responses in neonatally immunized rabbits
30. Alteration of airway reactivity by mucus
31. Spectrum of prostanoid release after bronchoalveolar allergen challenge in atopic asthmatics and in control groups: An alteration in the ratio of bronchoconstrictive to bronchoprotective mediators
32. Dry air-induced mucosal cell injury and bronchovascular leakage in canine peripheral airways
33. Hyperpnea with dry air causes time-dependent alterations in mucosal morphology and bronchovascular permeability
34. Expression of eotaxin by human lung epithelial cells: Induction by cytokines and inhibition by glucocorticoids
35. Participation of interleukin-5 and interleukin-8 in the eosinophil migration induced by a large volume of saline
36. Expression of the potent inflammatory cytokines, granulocyte-macrophage - Colony-stimulating factor and interleukin-6 and interleukin-8, in bronchial epithelial cells of patients with asthma
37. 4 in response to calcium ionophone
38. Effect of inhaled heparin on allergen-induced early and late asthmatic responses in patients with atopic asthma
39. Inhibition of allergic late airway responses by inhaled heparin-derived oligosaccharides
40. Pharmacokinetics of an unfractionated heparin (Liquemin) in the dog after intravenous and subcutaneous application based on heparin activity
41. Inhibition of complement dependent experimental inflammation in human skin by different heparin fractions
42. Inhibition of antigen-induced acute bronchoconstriction, airway hyperresponsiveness, and mast cell degranulation by a nonanticoagulant heparin: Comparison with a low molecular weight heparin
43. Immunologic mast cell-mediated responses and histamine release are attenuated by heparin
44. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation
45. The inhibitory effect of heparin and related glycosaminoglycans on neutrophil chemotaxis
46. Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity
47. 2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate
48. Characterization of inositol triphosphate receptor binding in brain: Regulation by pH and calcium
49. Heparin inhibits the inositol 1,4,5-triphosphate-dependent, but not the independent, calcium release induced by guanine nucleotide in vascular smooth muscle
50. Differential regulation of eosinophil adhesion and transmigration by pulmonary microvascular endothelial cells
51. Integrin alpha 4 beta mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin
52. Effect of fibronectin on the production of leukotriene C4 by eosinophils
53. Interleukin-5 binds to heparin/heparan sulfate. A model for an interaction with extracellular matrix
54. Regulation of interleukin-8 binding and function by heparin and alpha2-macroglobulin
55. Heparin inhibits allergen-induced eosinophil infiltration into guinea-pig lung via a mechanism unrelated to its anticoagulant activity
56. Mechanisms of inhibition by heparin of PDGF stimulated MAP kinase activation in vascular smooth muscle cells
57. Selective regulation of T cell IL-5 synthesis by OM-01, JTE-711 and p38 MAP kinase inhibitor: Independent control of Th2 cytokines, IL-4 and IL-5
58. Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway
59. Eicosanoids modulate hyperventilation-induced late phase airway obstruction and hyperreactivity, but not inflammation, in dogs
60. Heparin and PGE(2) inhibit DNA synthesis in human airway smooth muscle cells in culture
61. Airway and tissue behavior during induced constriction in rats: Intravenous vs aerosol administration