Inhibition of antigen-induced acute bronchoconstriction, airway hyperresponsiveness, and mast cell degranulation by a nonanticoagulant heparin: Comparison with a low molecular weight heparin

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 6, 1997, Pages 1848-1855

  Ahmed, Tahir ^a,b   Campo, Carlos ^a   Abraham, Michael K ^a   Molinari, Jussara F ^a   Abraham, William M ^a   Ashkin, David ^a   Syriste, Thomas ^a   Andersson, Lars O ^a   Svahn, Carl M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN DERIVATIVE; LOW MOLECULAR WEIGHT HEPARIN;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; INHALATIONAL DRUG ADMINISTRATION; MAST CELL DEGRANULATION; NONHUMAN; PRIORITY JOURNAL; SHEEP;

EID: 0030968807     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.6.9196085     Document Type: Article

References (38)

1. Jacques, L. B. 1979. Heparins: anionic polyelectrolyte drugs. Pharmacol. Rev. 31:99-166.
2. Linhardt, R. J., and D. Loganathan. 1990. Heparin, heparinoids and heparin oligosaccharides: structure and biological activities. In C. G. Gebelein, editor. Biomimetic Polymers. Plenum Press, New York. 135-173.
3. Lindahl, U. 1989. Biosynthesis of heparin and related polysaccharides. In D. A. Lane and U. Lindahl, editors. Heparin, Chemical and Biological Properties, Clinical Applications. CRC Press, Boca Raton, FL. 159-189.
4. O'Reilly, R. A. 1980. Anticoagulant, antithrombotic and thrombolytic drugs. In A. G. Goodman, L. S. Goodman, and A. Gilman, editors. The Pharmacological Basis of Therapeutics. MacMillan Publishing Co., New York. 1348-1352.
5. Cifonelli, J. A. 1974. The relationship of molecular weight and sulfate content and distribution to anticoagulant activity of heparin preparations. Carbohydr. Res. 37:145-154.
6. Schwartz, L. B., and T. R. Bradford. 1986. Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J. Biol. Chem. 261:7372-7379.
7. Schwartz, L. B., C. Riedel, J. P. Caulfield, S. I. Wasserman, and K. F. Austen. 1981. Cell association of complexes of chymase, heparin proteoglycan, and protein after degranulation by rat mast cells. J. Immunol. 126:2071-2078.
8. Castellot, J. J., Jr., D. L. Cochran, and M. J. Karnovsky. 1985. Effect of heparin on vascular smooth muscle cells. 1. Cell metabolism. J. Cell. Physiol. 124:21-28.
9. Wright, T. C., Jr., T. V. Johnstone, J. J. Castellot, Jr., and M. J. Karnovsky. 1985. Inhibition of rat cervical epithelial cell growth by heparin and its reversal by EGF. J. Cell. Physiol. 125:499-506.
10. Trybala, E., T. Bergström, D. Spillman, B. Svennerhölm, S. Olofsson, S. J. Flynn, and P. Ryan. 1996. Mode of interaction between pseudorabies virus and heparan sulfate/heparin. Virology 218:35-42.
11. Weiler, J. M., R. E. Edens, R. J. Linhardt, and D. P. Kapelanski. 1992. Heparin and modified heparin inhibit complement activation in vivo. J. Immunol. 148:3210-3215.
12. Dolowitz, D. A., and T. F. Dougherty. 1960. The use of heparin as an anti-inflammatory agent. Laryngoscope 70:873-884.
13. Lider, O., Y. A. Mekori, T. Miller, R. Bar-Tana, I. Vlodavsky, E. Baharav, I. R. Cohen, and Y. Naparstek. 1990. Inhibition of T-lymphocyte heparanase by heparin prevents T cell migration and T cell mediated immunity. Eur. J. Immunol. 20:493-499.
14. Matzner, Y., G. Marx, R. Drexler, and A. Eldor. 1984. The inhibitory effect of heparin and related glycosaminoglycans on neutrophil chemotaxis. Thromb. Haemost. 52:134-137.
15. Seeds, E. A. M., J. Hanss, and C. P. Page. 1993. The effect of heparin and related proteoglycans on allergen and PAF-induced eosinophil infiltration. J. Lipid Mediat. 7:269-278.
16. Ahmed, T., W. M. Abraham, and J. D'Brot. 1992. Effects of inhaled heparin on immunologie and nonimmunologic bronchoconstrictor responses in sheep. Am. Rev. Respir. Dis. 145:566-570.
17. Ahmed, T., J. Garrigo, and I. Danta. 1993. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N. Engl. J. Med. 329:90-95.
18. Garrigo, J., I. Danta, and T. Ahmed. 1996. Time course of the protective effect of inhaled heparin on exericse-induced asthma. Am. J. Respir. Crit. Care Med. 153:1702-1707.
19. Bowler, S. D., S. M. Smith, and P. S. Lavercombe. 1993. Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am. Rev. Respir. Dis. 147:160-163.
20. Diamant, Z., M. C. Timmers, H. van der Veen, C. P. Page, F. J. van der Meer, and P. J. Sterk. 1996. Effect of inhaled heparin on allergen-induced early and late asthmatic responses in patients with atopic asthma. Am. J. Respir. Crit. Care Med. 153:1790-1795.
21. Ahmed, T., J. D'Brot, W. M. Abraham, J. Lucio, R. Mendelssohn, M. J. Robinson, S. Shakir, and B. SanPedro. 1996. Heterogeneity of allergic airway responses in sheep: differences in signal transduction? Am. J. Respir. Crit. Care Med. 154:843-849.
22. 2 receptors in airway reactions to histamine in conscious sheep. J. Appl. Physiol. 49:826-833.
23. 3-mediated mast cell degranulation? J. Appl. Physiol. 76:893-901.
24. Völker, W., A. Böhm, A. Schmidt, C. M. Svahn, A. K. Gellerbring, C. Mattsson, S. Ekvän, H. Robenek, and E. Buddecke. 1995. Inhibition of smooth muscle cell proliferation and neointimal growth by low-anticoagulant heparin. Arzneimittelforschung. 45:546-550.
25. Howell, R. E., and S. L. Woeppel. 1993. Potential species dependency for the pulmonary antiallergic effects of aerosolized heparin. Pulm. Pharmacol. 6:237-239.
26. Lucio, J., J. D'Brot, C. B. Guo, W. M. Abraham, L. M. Lichtenstein, A. Kagey-Sobotka, and T. Ahmed. 1992. Immunologie mast cell-mediated responses and histamine release are attenuated by heparin. J. Appl. Physiol. 73:1093-1101.
27. Abraham, W. M., M. K. Abraham, and T. Ahmed. 1996. Protective effect of heparin on immunologically induced tracheal smooth muscle contraction in vitro. Int. Arch. Allergy Immunol. 110:79-84.
28. Ghosh, T. K., P. S. Eis, J. M. Mullaney, C. L. Ebert, and D. L. Gill. 1988. Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin. J. Biol. Chem. 263: 11075-11079.
29. Kobayashi, S., A. V. Somlyo, and A. P. Somlyo. 1988. Heparin inhibits the inositol 1,4,5-trisphosphate-dependent, but not the independent, calcium release induced by guanine nucleotide in vascular smooth muscle. Biochem. Biophys. Res. Commun. 153:625-631.
30. Tones, M. A., M. D. Bootman, B. F. Higgins, D. A. Lane, G. F. Pay, and U. Lindahl. 1989. The effect of heparin on the inositol 1,4,5-trisphosphate receptor in rat liver microsomes: dependence on sulphate content and chain length. FEBS Lett. 252:105-108.
31. Worley, P. F., J. M. Baraban, S. Supattapone, V. S. Wilson, and S. H. Snyder. 1987. Characterization in inositol trisphosphate receptor binding in brain: regulation by pH and calcium. J. Biol. Chem. 262:12132-12136.
32. Chilvers, E. R., R. A. Challiss, A. L. Willcocks, B. V. Potter, P. J. Barnes, and S. R. Nahorski. 1990. Characterization of stereospecific binding sites for inositol 1,4,5-trisphospate in airway smooth muscle. Br. J. Pharmacol. 99:297-302.
33. Hoth, M., and R. Penner. 1992. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355:353-356.
34. Takeda, M., Y. Imaizumi, and M. Watanabe. 1991. Effects of noradrenaline and heparin on outward current in single smooth muscle cells of the guinea pig vas deferens. Eur. J. Pharmacol. 193:375-378.
35. Streusand, V. J., I. Björk, P. G. W. Gettins, M. Petitou, and S. T. Olson, 1995. Mechanism of acceleration of antithrombin-proteinase reactions by low affinity heparin: role of the antithrombin binding pentasaccharide in heparin rate enhancement. Biol. Chem. 270:9043-9051.
36. Barzu, T., J. L. M. L. Van Rijn, M. Petitou, P. Molho, G. Tobelem, and J. P. Caen. 1986. Endothelial binding sites for heparin: specificity and role in heparin neutralization. Biochem. J. 238:847-854.
37. Palm, M., and C. Mattsson. 1987. Pharmacokinetics of fragmin: a comparative study in the rabbit of its high and low affinity forms of antithrombin. Thromb. Res. 48:51-62.
38. Lindahl, U., G. Bäckström, and L. Thunberg. 1983. The antithrombinbinding sequence of heparin: identification of an essential 6-0-sulfated group. J. Biol. Chem. 258:9826-9830.