Selective regulation of T cell IL-5 synthesis by OM-01, JTE-711 and p38 MAP kinase inhibitor: Independent control of Th2 cytokines, IL-4 and IL-5

International Archives of Allergy and Immunology

Volumn 124, Issue 1-3, 2001, Pages 172-175

  Mori, Akio ^a   Okudaira, Hirokazu ^b   Kobayashi, Noriaki ^c   Akiyama, Kazuo ^a  

^a SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Technical College   (Japan)

Author keywords

Asthma; Cytokine; Eosinophil; Helper T cell; OM 01

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOSPORIN A; CYTOKINE; DEXAMETHASONE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; JTE 711; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NONACTIN; PHTHALIMIDE; SB 230580; UNCLASSIFIED DRUG;

ANIMAL MODEL; ASTHMA; CONFERENCE PAPER; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; EOSINOPHILIA; HELPER CELL; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOCYTE CLONE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH2 CELL;

ANIMALS; ANTI-BACTERIAL AGENTS; ASTHMA; CLONE CELLS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INTERLEUKIN-4; INTERLEUKIN-5; MACROLIDES; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, IMMUNOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHTHALIMIDES; PULMONARY EOSINOPHILIA; PYRIDINES; T-LYMPHOCYTES, HELPER-INDUCER; TH2 CELLS;

EID: 0035051557     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053702     Document Type: Conference Paper

References (19)

1. 'Helper' (CD4+) T cells and eosinophils in allergy and asthma
2. The eosinophil and bronchial asthma: Current understanding
3. Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung
4. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma
5. Interleukin-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A
6. Cellular and molecular mechanisms of IL-5 synthesis in atopic diseases - A study with allergen-specific human helper T cells
7. Transcriptional control of IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis
8. A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones
9. IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506
10. Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids
11. Selective suppression of IL-5 synthesis by OM-01
12. p38 mitogen-activated protein kinase regulates human T cell IL-5 synthesis
13. IL-15 promotes cytokine production of human helper T cells
14. A sandwich enzyme-linked immunosorbent assay for human interleukin-5
15. Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells
16. IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction
17. Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma
18. Tacrolimus ointment for atopic dematitis
19. Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma