Induction of p21 mRNA synthesis after short-wavelength UV light visualized in individual cells by RNA FISH

Journal of Histochemistry and Cytochemistry

Volumn 50, Issue 1, 2002, Pages 81-89

  Hattinger, Claudia M ^a   Jochemsen, Aart G ^a   Tanke, Hans J ^a   Dirks, Roeland W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Human fibroblasts; p21; RNA FISH; Speckles; UVC irradiation

Indexed keywords

DNA; MESSENGER RNA; PROTEIN P21;

ARTICLE; BLOOM SYNDROME; CELL SURVIVAL; DNA DAMAGE; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL; RNA STABILITY; RNA SYNTHESIS; ULTRAVIOLET IRRADIATION;

EID: 0036143450     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540205000109     Document Type: Article

References (35)

1. Demonstration of a dynamic, transcription-dependent organization of pre-mRNA splicing factors in polytene nuclei
2. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
3. Inefficient processing impairs release of RNA from the site of transcription
4. Splicing factors associate with nuclear HCMV transcripts after transcriptional activation of the gene, but dissociate upon transcription inhibition: Evidence for a dynamic organization of splicing factors
5. Synthesis, processing and transport of RNA within the three-dimensional context of the cell nucleus
6. Methodologies for specific intron and exon RNA localization in cultured cells by haptenized and fluorochromized probes
7. In vivo gene therapy with p53 or p21 adenovirus for prostate cancer
8. WAF1/CIP is induced in p53-mediated G1 arrest and apoptosis
9. WAF1, a potential mediator of p53 tumor suppression
10. CIP1/WAF1 protein accumulation in head-and-neck cancer
11. p21 (WAF1/CIP1) expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line
12. Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells
13. waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system
14. + RNA
15. Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis
16. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
17. Inhibition of RNA polymerase II as a trigger for the p53 response
18. A p53-independent pathway for induction of p21cip1 and concomitant G1 arrest in UV-irradiated human skin fibroblasts
19. Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
20. waf1 and bax expression: Implications for DNA repair, UV sensitivity and the induction of apoptosis
21. Nuclear pre-mRNA compartmentalization: Trafficking of released transcripts to splicing factor reservoirs
22. The cellular organization of gene expression
23. The cyclin-dependent kinase inhibitor p21 is required for survival of differentiating neuroblastoma cells
24. 5′-Terminal caps of snRNAs are reactive with antibodies specific for 2,2,7-trimethylguanosine in whole cells and nuclear matices
25. Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific
26. CCD microscopy and image analysis of cells and chromosomes stained by fluorescence in situ hybridization
27. GM1492 human diploid skin fibroblasts lack the p53-dependent G1 cell-cycle checkpoint
28. The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA
29. Localization of premessenger RNA at discrete nuclear sites
30. WAF1/CIP1 in human cancer cells independently of p53
31. HuR regulates p21 mRNA stabilization by UV light
32. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation
33. Higher level organization of individual gene transcription and RNA splicing
34. Nonrandom gene organization: Structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains
35. Nuclear RNA tracks: Structural basis for transcription and splicing?