Loss of p53 and c-myc overrepresentation in stage t2-3 n1-3m0 prostate cancer are potential markers for cancer progression

Modern Pathology

Volumn 15, Issue 1, 2002, Pages 35-44

  Qian, Junqi ^a   Hirasawa, Kiyoshi ^a   Bostwick, David G ^a   Bergstralh, Erik J ^a   Slezak, Jeff M ^a   Anderl, Karl L ^a   Borell, Thomas J ^a   Lieber, Michael M ^a   Jenkins, Robert B ^a  

^a MAYO CLINIC   (United States)

Author keywords

7Q31; 8P22; C myc; Fish; Metastasis; P53; Prostate

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER STAGING; CHROMOSOME 17P; CHROMOSOME 7Q; CHROMOSOME 8P; CHROMOSOME 8Q; CONTROLLED STUDY; DISEASE MARKER; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; ONCOGENE C MYC; PRIORITY JOURNAL; PROSTATE CARCINOMA;

AGED; CARCINOMA; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 7; CHROMOSOMES, HUMAN, PAIR 8; COHORT STUDIES; DISEASE PROGRESSION; GENES, MYC; GENES, P53; GENETIC MARKERS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROSTATE; PROSTATIC NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 0036141621     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3880487     Document Type: Article

References (42)

1. Cancer statistics
2. Staging of prostate cancer
3. Natural history of localised prostatic cancer: A population based study in 223 untreated patients
4. Molecular markers for prostate cancer metastasis. Developing diagnostic methods for predicting the aggressiveness of prostate cancer
5. Determination of gene and chromosome dosage in prostatic intraepithelial neoplasia and carcinoma
6. Review of allelic loss and gain in prostate cancer
7. Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21
8. Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer
9. Allelic imbalance and microsatellite instability in prostatic adenocarcinoma
10. Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia (PIN)
11. Fluorescence in situ hybridization analysis of 8p allelic loss and chromosome 8 instability in human prostate cancer
12. Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization
13. Comparative genomic hybridization, allelic imbalance, and fluorescence in situ hybridization on chromosome 8 in prostate cancer
14. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization
15. Clinical significance of alterations of chromosome 8 in high-grade, advanced, nonmetastatic prostate carcinoma
16. p53 immunoreactivity in primary and metastatic prostatic adenocarcinoma
17. p53, bcl-2 and retinoblastoma proteins as long-term prognostic markers in localized carcinoma of the prostate
18. An uncertain role for p53 gene alterations in human prostate cancers
19. Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression
20. 0 prostate cancer
21. Comparison of fluorescence in situ hybridization analysis of isolated nuclei and routine histological sections from paraffin-embedded prostatic adenocarcinoma specimens
22. Chromosomal anomalies in prostatic intraepithelial neoplasia and carcinoma detected by fluorescence in situ hybridization
23. Gleason grading of prostatic needle biopsies: Correlation with grade in 316 matched prostatectomies
24. Independent origin of multiple foci of prostatic intraepithelial neoplasia: Comparison with matched foci of prostate carcinoma
25. Activation of a cellular oncogene by promoter insertion in ALV-induced lymphoid leukosis
26. Myc family oncogenes in the development of normal and neoplastic cells
27. Myc and the cell cycle
28. Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping
29. Interphase cytogenetics of prostatic tumor progression: Specific chromosomal abnormalities are involved in metastasis to the bone
30. Extensive genetic alterations in prostate cancer revealed by dual PCR and FISH analysis
31. Frequency and pattern of karyotypic abnormalities in human prostate cancer
32. A molecular cytogenetic analysis of 7q31 in prostate cancer
33. Alterations of p53 gene are associated with the progression of a human prostate carcinoma
34. Primary human prostate cancer cells harboring p53 mutations are clonally expanded in metastases
35. Association of p53 mutations with metastatic prostate cancers
36. Loss of p53 function leads to metastasis in ras+myc-induced mouse prostate cancer
37. Allelic loss in locally metastatic, multisampled prostate cancer
38. Genetic alterations in hormone-refractory recurrent prostate carcinomas
39. Prostate cancer progression, metastasis, and gene expression in transgenic mice
40. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues
41. Evidence of independent origin of multiple tumors from patients with prostate cancer