Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans

Infection and Immunity

Volumn 70, Issue 1, 2002, Pages 335-344

  Tsirpouchtsidis, A ^a   Hurwitz, R ^a   Brinkmann, V ^a   Meyer, T F ^a   Haas, G ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN A1 PROTEASE; INTERLEUKIN 10; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEINASE; T LYMPHOCYTE ANTIGEN; TETANUS TOXOID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MONONUCLEAR CELL; NATURAL KILLER CELL; NEISSERIA; NORMAL HUMAN; PATHOGENICITY; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL;

ADULT; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CELLS, CULTURED; CYTOKINES; HUMANS; INTERFERON TYPE II; INTRACELLULAR FLUID; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MEMBRANE GLYCOPROTEINS; MONOCYTES; NEISSERIA GONORRHOEAE; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES;

EID: 0036137148     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.1.335-344.2002     Document Type: Article

References (75)

1. Subclass distribution of salivary secretory immunoglobulin A antibodies to oral streptococci
2. Auto-transporter A protein of Neisseria meningitidis: A potent CD4+ T-cell and B-cell stimulating antigen detected by expression cloning
3. Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents
4. Recurrent meningococcemia associated with IgG2-subclass deficiency
5. IgA1 protease from Neisseria gonorrhoeae inhibits TNF alpha-mediated apoptosis of human monocytic cells
6. Tumor necrosis factor-alpha contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis
7. Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease
8. Humoral immune response to gonococcal infections
9. Antibodies against IgA1 protease are stimulated both by clinical disease and asymptomatic carriage of serogroup A Neisseria meningitidis
10. Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: Pathway of presentation and regulation by cytokines
11. The genetics of the gonococcus
12. Neisseria meningitidis: Clinical aspects
13. Interferon gamma inhibits interleukin 10 production by monocytes
14. A homing selection hypothesis for T-cell trafficking
15. Host cell invasion by pathogenic neisseriae
16. Immunogenicity and safety of a hexavalent meningococcal outer-membrane-vesicle vaccine in children of 2-3 and 7-8 years of age
17. Pathophysiology of meningococcal sepsis in children
18. Interaction of complement with Neisseria meningitidis and Neisseria gonorrhoeae
19. Postinfectious human serum antibodies inhibit IgA1 proteinases by interaction with the cleavage site specificity determinant
20. Haemophilus influenzae and Streptococcus pneumoniae induce different intracerebral mRNA cytokine patterns during the course of experimental bacterial meningitis
21. An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues
22. Vaccines for prevention of meningococcal disease
23. Cross-antigenicity and immunogenicity between capsular polysaccharides of group C Neisseria meningitidis and of Escherichia coli K92
24. Human immunity to the meningococcus. II. Development of natural immunity
25. Lipopolysaccharide stimulates the proliferation of human CD56+CD3- NK cells: A regulatory role of cytes and IL-10
26. Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development
27. Effects of protein I of Neisseria gonorrhoeae on neutrophil activation: Generation of diacylglycerol from phosphatidylcholine via a specific phospholipase C is associated with exocytosis
28. Activation of human peripheral blood mononuclear cells by nonpathogenic bacteria in vitro: Evidence of NK cells as primary targets
29. The lysosomal/phagosomal membrane protein h-lamp-1 is a target of the IgA1 protease of Neisseria gonorrhoeae
30. Relation between cytokines and routine laboratory data in children with septic shock and purpura
31. Evaluation of immunoglobulin A1 (IgA1) protease and IgA1 protease-inhibitory activity in human female genital infection with Neisseria gonorrhoeae
32. Endotoxin and muramyl dipeptide modulate surface receptor expression on human mononuclear cells
33. Effects of the immunoglobulin A1 protease on Neisseria gonorrhoeae trafficking across polarized T84 epithelial monolayers
34. Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans
35. Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: Critical evaluation of experimental evidence
36. Perturbation of mucosal immune defence mechanisms by bacterial IgA proteases
37. Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen
38. Characterization of the Neisseria Iga beta-core. The essential unit for outer membrane targeting and extracellular protein secretion
39. Intrathecal production of interleukin-12 and gamma interferon in patients with bacterial meningitis
40. Cross-presentation: Inducing CD8 T cell immunity and tolerance
41. Antibody-antigen specificity in the immune response to infection with Neisseria gonorrhoeae
42. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
43. The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells
44. Antigenic relationships among immunoglobulin A1 proteases from Haemophilus, Neisseria, and Streptococcus species
45. Comparative characterization of the iga gene encoding IgA1 protease in Neisseria meningitidis, Neisseria gonorrhoeae and Haemophilus inftuenzae
46. Immunoglobulin A1 protease, an exoenzyme of pathogenic neisseriae, is a potent inducer of proinflammatory cytokines
47. Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis
48. Biology of the pathogenic neisseriae
49. IgA protease production as a characteristic distinguishing pathogenic from harmless Neisseriaceae
50. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases
51. Depletion of interleukin-4 in BALB/c mice with established Leishmania major infections increases the efficacy of antimony therapy and promotes Th1-like responses
52. Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine
53. Tumour necrosis factor alpha antibody protects against lethal meningococcaernia
54. The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis
55. Neisseria gonorrhoeae and Neisseria meningitidis: Extracellular enzyme cleaves human immunoglobulin A
56. Epidemiologic evidence for the development of serovar-specific immunity after gonococcal infection
57. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
58. Sequence-specific cleavage of protein fusions using a recombinant Neisseria type 2 IgA protease
59. Cellular immune responses to Neisseria meningitidis in children
60. Humoral immune responses to Neisseria meningitidis in children
61. CD4+ Th2 cell response cytokine production in bacterial meningitis
62. Gamma delta T lymphocytes and proinflammatory cytokines in bacterial meningitis
63. Cleavage of the hormone human chorionic gonadotropin, by the type 1 IgA1 protease of Neisseria gonorrhoeae, and its implications
64. Subnormal serum concentrations of IgG2 in children with frequent infections associated with varied patterns of immunologic dysfunction
65. Blood-brain barrier damage in patients with bacterial meningitis: Association with tumor necrosis factor-alpha but not interleukin-1 beta
66. Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD
67. Persistence of antibodies to meningococcal IgA1 protease versus decay of antibodies to group A polysaccharide and Opc protein
68. Characterization of the serum antibody response to the capsular polysaccharide of Haemophilus influenzae type b in children with invasive infections
69. Roles of proinflammatory and anti-inflammatory cytokines in pathophysiology of bacterial meningitis and effect of adjunctive therapy
70. High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during the onset of bacterial meningitis
71. Invasive isolates of Neisseria meningitidis possess enhanced immunoglobulin A1 protease activity compared to colonizing strains
72. The complex pattern of cytokines in serum from patients with meningococcal septic shock: Association between interleukin 6, interleukin 1, and fatal outcome
73. T-cell responses to outer membrane proteins of Neisseria meningitidis: Comparative study of the Opa, Opc, and PorA proteins
74. Identification and characterization of specific sequences encoding pathogenicity associated proteins in the genome of commensal Neisseria species
75. Gonorrhea: Clinical and public health issues