Enantiopure building blocks for chiral drugs from racemic mixtures of secondary alcohols by combination of lipase catalysis and Mitsunobu esterification

Chirality

Volumn 14, Issue 1, 2002, Pages 25-27

  Liu, Hui Ling ^a   Anthonsen, Thorleif ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Chiral building blocks; Enantiopure esters; Lipase catalysis

Indexed keywords

1 CHLORO 3 (3,4 DIFLUOROPHENOXY) 2 PROPANOL; 3 CHLORO 1 (2 THIENYL) 1 PROPANOL; 3 CHLORO 1 PHENYLPROPANOL; ALCOHOL; BUTYRIC ACID; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; ESTERIFICATION; HYDROLYSIS; PRIORITY JOURNAL; REACTION ANALYSIS;

ALCOHOLS; BUTYRIC ACIDS; CATALYSIS; DRUG DESIGN; ESTERIFICATION; LIPASE; STEREOISOMERISM;

EID: 0036136987     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10037     Document Type: Article

References (10)

1. Ruthenium- and enzyme-catalyzed dynamic kinetic resolution of secondary alcohols
2. Preparation of optically active secondary alcohols by combination of enzymatic hydrolysis and chemical transformation
3. Enantiocomplementary preparation of optically pure 2-trimethylsilylethnyl-2-cyclopentenol by homochiralization of racemic precursors: A new route to the key intermediate of 1,25-dihydroxycholecalciferol and Vincamine
4. Combination of lipase catalysed resolution with Mitsunobu esterification in one pot
5. Chemo-enzymatic synthesis of the antidepressant Duloxetine and its enantiomer
6. Chemo-enzymatic synthesis of both enantiomers of the nontricyclic antidepressants Fluoxetine, Nisoxetine and Tomoxetine
7. Synthesis of the anti-stroke drug Lubeluzole and its enantiomer. Lipase-catalysed resolution of chiral building block
8. Resolution of derivatives of 1,2-propanediol with lipase B from Candida antarctica. Effect of substrate structure, medium, water activity and acyl donor on enantiomeric ratio
9. A rule to predict which enantiomer of secondary alcohol reacts faster in reaction catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa
10. Quantitative analyses of biochemical kinetic resolutions of enantiomers