Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart

Cardiovascular Research

Volumn 53, Issue 1, 2002, Pages 147-155

  Harrison, Glenn J ^a   Cerniway, Rachael J ^b   Peart, Jason ^a   Berr, Stuart S ^b   Ashton, Kevin ^a   Regan, Sara ^b   Paul Matherne, G ^b   Headrick, John P ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Adenosine; Gene expression; Ischemia; NMR; Receptors; Reperfusion; Stunning

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLURONAMIDE; 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5 PHENYLACETYLAMINO 1,2,4 TRIAZOLO[1,5 C]QUINAZOLINE; ADENOSINE A3 RECEPTOR; ADENOSINE TRIPHOSPHATE; AMIDE; CREATINE PHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTRACTURE; CONTROLLED STUDY; CYTOSOL; ENERGY METABOLISM; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; GENOTYPE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; KNOCKOUT GENE; NONHUMAN; PH; PHENOTYPE; PRIORITY JOURNAL; RAT; REPERFUSION;

ADENOSINE; AMINO ACIDS; ANIMALS; CREATINE; HEART RATE; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PERFUSION; PHENETHYLAMINES; PIPECOLIC ACIDS; QUINAZOLINES; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; TRIAZOLES; XANTHINES;

EID: 0036135889     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00424-2     Document Type: Article

References (42)

1. 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence
2. 2a agonist CGS-21680 in infarcted and stunned porcine myocardium
3. 3 receptors
4. Distinct cardioprotective effects of adenosine mediated by differential coupling of receptor subtypes to phospholipases C and D
5. 6-(3-iodobenzyl)adenosine-5′-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits
6. 3 receptors in protection of isolated human atrial muscle against simulated ischaemia
7. 3 receptors in mediating physiological or pharmacological protection from ischemic myocardial injury in the rabbit heart
8. ATP channels
9. 3 receptors increases myocardial resistance to ischemia-reperfusion injury
10. 3 receptor knock-out mice are resistant to ischemic injury and exhibit early ischemic preconditioning
11. 3 adenosine receptor confers resistance to myocardial ischemic injury and does not prevent early preconditioning
12. 3 receptors: Novel ligands and paradoxical effects
13. 3 adenosine receptor activation and its suppression by isoproterenol
14. 3 receptors
15. Adenosine antagonism attenuates metabolic but not functional recovery from ischemia
16. Protective effects of adenosine in the reversibly injured heart
17. Protective effects of adenosine in the perfused rat heart: Changes in metabolism and intracellular ion homeostasis
18. 1 adenosine receptor overexpression improves myocardial energy state during ischemia-reperfusion
19. 3 adenosine receptor gene in mice and its effects on stimulated inflammatory cells
20. 1 adenosine receptors mimics ischemic preconditioning
21. 1 adenosine receptors during ischemia and reperfusion improves ischemic tolerance
22. Functional and metabolic effects of extracellular magnesium in normoxic and ischemic myocardium
23. 3 receptors: Pharmacological properties, species differences and receptor functions
24. 3 pretreatment before cardioplegic arrest attenuates postischemic cardiac dysfunction
25. 1 adenosine receptor over-expression increases myocardial resistance to ischemia
26. 1 receptors in ischemic rat hearts
27. 1 receptor mediated protection of the globally ischemic isolated rat heart
28. 1 receptor mechanism
29. 1 receptor mediated protection of the ischemic rat heart
30. 1 receptor stimulation
31. 1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes
32. 1 receptor activation
33. 2′-C-Methyl analogues of selective adenosine receptor agonists: Synthesis and binding studies
34. 1 receptor stimulation during reperfusion following ischaemia
35. ATP-channel activation
36. 2A receptor in the modulation of myocardial reperfusion damage
37. 2A receptor agonists in the isolated rat heart
38. Unusual behavioral phenotypes of inbred mouse strains
39. 3 adenosine receptor in determining tissue levels of cAMP and blood pressure: Studies in knock-out mice
40. Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype?
41. Resistance to myocardial ischemia in five rat strains: Is there a genetic component of cardioprotection?
42. A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia