Antiangiogenic treatment delays chondrocyte maturation and bone formation during limb skeletogenesis

Journal of Bone and Mineral Research

Volumn 17, Issue 1, 2002, Pages 56-65

  Yin, Melinda ^a   Gentili, Chiara ^a,b   Koyama, Eiki ^a   Zasloff, Michael ^a   Pacifici, Maurizio ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Angiogenesis; Chondrocyte maturation; Endochondral ossification; Indian hedgehog; Limb development

Indexed keywords

ACID PHOSPHATASE; ANGIOGENESIS INHIBITOR; CELL PROTEIN; COLLAGEN TYPE 10; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE B; SONIC HEDGEHOG PROTEIN; SQUALAMINE; TARTARIC ACID; TRANSFERRIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL FUNCTION; CELL MATURATION; CHICK EMBRYO; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DIFFUSION; EMBRYO; FLUORESCENCE MICROSCOPY; GROWTH RETARDATION; HYPERTROPHY; IMPLANTATION; LIMB DEVELOPMENT; NONHUMAN; OSSIFICATION; OSTEOBLAST; PERICHONDRIUM; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ANGIOGENESIS INHIBITORS; ANIMALS; BONE DEVELOPMENT; CELLS, CULTURED; CHICK EMBRYO; CHOLESTANOLS; CHONDROCYTES; COLLAGEN TYPE X; EXTREMITIES; GROWTH SUBSTANCES; HEDGEHOG PROTEINS; HUMERUS; IMMEDIATE-EARLY PROTEINS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MATRIX METALLOPROTEINASE 9; TRANS-ACTIVATORS; TRANSFERRIN;

EID: 0036133515     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.1.56     Document Type: Article

References (38)

1. Bone development and repair
2. Morphological and histochemical events during first bone formation in embryonic chick limbs
3. Growth plate formation, structure, and function
4. Microvascular organization at the epiphyseal-metaphyseal junction of growing rats
5. Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: Autoparacrine role during endochondral bone formation
6. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
7. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
8. Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development
9. Authentic matrix vesicles contain active metalloproteases: A role for matrix vesicle-associated MMP-13 in activation of TGF(beta)
10. Ovotransferrin and ovotransferrin receptor expression during chondrogenesis and endochondral bone formation in developing chick embryo
11. Transferrin promotes endothelial cell migration and invasion: Implication in cartilage neovascularization
12. Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
13. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
14. Transcription factor ERG variants and functional diversification of chondrocytes during limb long bone development
15. Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb
16. The role of type X collagen in endochondral ossification as deduced by Fourier transform infrared microscopy analysis
17. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
18. Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature
19. Squalamine: An aminosterol antibiotic from the shark
20. Squalamine, a novel cationic steroid, specifically inhibits the brush- border Na+/H+ exchanger isoform NHE3
21. Squalamine improves retinal neovascularization
22. Rapid induction of type X collagen gene expression in cultured chick vertebral chondrocytes
23. Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytes
24. Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of dexamethasone
25. Developmentally regulated synthesis of a low molecular weight protein (Ch 21) by differentiating chondrocytes
26. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo
27. Retinoid signaling is required for chondrocyte maturation and endochondral bone formation during limb skeletogenesis
28. Effects of matrix macromolecules on chondrocyte gene expression: Synthesis of a low molecular weight collagen species by cells cultured within collagen gels
29. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state
30. Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones
31. Retinoic acid responsiveness of cells and tissues in developing fetal limbs evaluated in a RAREhsplacZ transgenic mouse model
32. Vis-a-vis cells and the priming of bone formation
33. Bone formation via cartilage models: The "borderline" chondrocyte
34. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
35. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
36. Early chick limb cartilaginous elements possess polarizing activity and express hedgehog-related morphogenetic factors
37. Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva
38. Fibrodysplasia ossificans progressiva: Searching for the skeleton key