Epstein-barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2

Journal of Virology

Volumn 76, Issue 1, 2002, Pages 232-242

  Lin, J ^a   Johannsen, E ^a   Robertson, E ^a   Kieff, E ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN 2; EPSTEIN BARR VIRUS ANTIGEN 3C; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; DNA SEQUENCE; EPSTEIN BARR VIRUS; GENE ACTIVATION; GENE CONTROL; GENE REPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE TRANSFORMATION; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

ANTIGENS, VIRAL; B-LYMPHOCYTES; CELL LINE; CELL TRANSFORMATION, VIRAL; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 0036133284     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.1.232-242.2002     Document Type: Article

References (65)

1. Epstein-Barr virus (EBV) nuclear antigen 6 induces expression of the EBV latent membrane protein and an activated phenotype in Raji cells
2. 1-arrested cells
3. Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA
4. An Epstein-Barr virus nuclear protein 2 domain essential for transformation is a direct transcriptional activator
5. Modulation of histone acetyltransferase activity through interaction of Epstein-Barr nuclear antigen 3C with prothymosin alpha
6. The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb
7. SUMO-1 modification of IκBα inhibits NF-κB activation
8. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor
9. Cell phenotype-dependent control of Epstein-Barr virus latent membrane protein 1 gene regulatory sequences
10. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins
11. Regulation of the Epstein-Barr virus C promoter by AUF1 and the cyclic AMP/protein kinase A signaling pathway
12. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
13. The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the JK recombination signal binding protein
14. Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C
15. The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels
16. Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation
17. Epstein-Barr virus nuclear protein 2 has at least two N-terminal domains that mediate self-association
18. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jκ
19. Masking of the CBF1/RBP-Jκ transcriptional repression domain by Epstein-Barr virus EBNA2
20. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
21. Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by Jκ and PU.1
22. The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2
23. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
24. The amino-terminus and membranespanning domains of LMP-1 inhibit cell proliferation
25. Epstein-Barr virus and its replication
26. Cell cycle stage-specific phosphorylation of the Epstein-Barr virus immortalization protein EBNA-LP
27. The Epstein-Barr virus determined nuclear antigens EBNA-3A, -3B, and -3C repress EBNA-2-mediated transactivation of the viral terminal protein 1 gene promoter
28. Pim-1 kinase and p100 cooperate to enhance c-Myb activity
29. EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif
30. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
31. Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator
32. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
33. Precipitation of the Epstein-Barr virus protein EBNA 2 by an EBNA 3C-specific monoclonal antibody
34. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
35. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
36. Epstein-Barr virus leader protein enhances EBNA-2-mediated transactivation of latent membrane protein 1 expression: A role for the W1W2 repeat domain
37. Conserved regions in the Epstein-Barr virus leader protein define distinct domains required for nuclear localization and transcriptional cooperation with EBNA2
38. oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines
39. Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21
40. Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription
41. Transactivation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1
42. Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein Jκ
43. The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBP-Jκ
44. SUMO-1 modification activates the transcriptional response of p53
45. GAL4-VP16 is an unusually potent transcriptional activator
46. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3
47. Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression
48. Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1
49. Epstein-Barr virus nuclear protein EBNA-3C interacts with the human metastatic suppressor Nm23-mH1: A molecular link to cancer metastasis
50. A promoter of Epstein-Barr virus that can function during latent infection can be transactivated by EBNA-1, a viral protein required for viral DNA replication during latent infection
51. The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2
52. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE
53. The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein
54. Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression
55. Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-Jκ-EBNA2-activated transcription by inhibiting the binding of RBP-Jκ to DNA
56. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
57. Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: Deletion of the amino terminus abolishes activity
58. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23
59. Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23
60. Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter
61. Genetic and biochemical evidence that EBNA 2 interaction with a 63-kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBV
62. Identification of major phosphorylation sites of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP): Ability of EBNA-LP to induce latent membrane protein 1 cooperatively with EBNA-2 is regulated by phosphorylation
63. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease
64. Epstein-Barr virus nuclear antigen 3C activates the latent membrane protein 1 promoter in the presence of Epstein-Barr virus nuclear antigen 2 through sequences encompassing an Spi1/Spi-B binding site
65. Role of SUMO-1-modified PML in nuclear body formation