Antiapoptotic and cytotoxic properties of delta opioid peptide [D-Ala2,D-Leu5]enkephalin in PC12 cells

Synapse

Volumn 43, Issue 1, 2002, Pages 86-94

  Hayashi, Teruo ^a   Tsao, Li I ^a   Su, Tsung Ping ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

DADLE; DNA laddering; ERK; Fas; Fas ligand; MAP kinase; Naltrexone; Opioid; PD98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; FAS LIGAND; LACTATE DEHYDROGENASE; METHAMPHETAMINE; MITOGEN ACTIVATED PROTEIN KINASE; MU OPIATE RECEPTOR ANTAGONIST;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA DAMAGE; DOSE RESPONSE; DRUG MECHANISM; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GENETIC TRANSFECTION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CENTRAL NERVOUS SYSTEM; CULTURE MEDIA, SERUM-FREE; CYTOTOXINS; DNA FRAGMENTATION; DNA, SINGLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, LEUCINE-2-ALANINE; ENZYME INHIBITORS; FAS LIGAND PROTEIN; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; L-LACTATE DEHYDROGENASE; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NARCOTIC ANTAGONISTS; NEURONS; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; RECEPTORS, OPIOID; TRANSFECTION;

EID: 0036132238     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10019     Document Type: Article

References (47)

1. Characterization of a delta opioid receptor in rat pheochromocytoma cells
2. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
3. Use of "natural" hibernation induction triggers for myocardial protection
4. Cell survival promoted by the ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
5. Treatment with delta opioid peptide enhances in vitro and in vivo survival of rat dopaminergic neurons
6. Agonist activation of p42 and p44 mitogen-activated protein kinase following expression of the mouse δ opioid receptor in Rat-1 fibroblasts: Effects of receptor expression levels and comparisons with G-protein activation
7. Chronic exposure to kappaopioids enhances the susceptibility of immortalized neurons (F-11kappa 7) to apoptosis-inducing drugs by a mechanism that involve ceramide
8. Opioid transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal
9. Cloning of a delta opioid receptor by functional expression
10. Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis
11. ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection
12. Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: Involvement of both opiate and glucocorticoid receptors
13. Functional coupling of the 8-, μ-, and κ-opioid receptors to mitogen-activated protein kinase and arachidonate release in Chinese hamster ovary cells
14. Phosphatidylinositol 3-kinase is an early intermediate in the Gbg-mediated mitogen-activated protein kinase signaling pathway
15. 5]enkephalin blocks the methamphetamine-induced c-fos mRNA increase in mouse brain
16. 5]enkephalin causes a near complete blockade of the neuronal damage induced by a single high dose of methamphetamine: Examining the role of p53
17. Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: Biochemical and immunofluorescence confocal microscopic evidence
18. The deltaopioid receptor: Isolation of a cDNA by expression cloning and pharmacological characterization
19. Agonist activation of delta-opioid receptor but not mu-opioid receptor potentiates fetal calf serum or tyrosine kinase receptor-mediated cell proliferation in a cell-line-specific manner
20. Linkage of G protein-coupled receptors to the MAPK signaling pathway through P13-kinasey
21. Opioids induce while nicotine suppresses apoptosis in human lung cancer cells
22. 2]deltorphin II in mice: Evidence for delta receptor subtypes
23. Spinal opioid delta antinociception in the mouse: Mediation by a 5′-NTII-sensitive delta receptor subtypes
24. Morphine-induced delay of normal cell death in the avian ciliary ganglion
25. Endogenous opioids modulate neuronal survival in the developing avian ciliary ganglion
26. Metenkephalin induces cytolytic processes of apoptosis type in K562 human erythroid leukemia cells
27. Agonist-mediated tyrosine phosphorylation of isoforms of the Shc adaptor protein by the δ opioid receptor
28. Extended lung preservation with the use of hibernation trigger factors
29. μ-opioid receptor activates signaling pathways implicated in cell survival and translational control
30. Opioids and cardioprotection
31. Ischemic preconditioning in the intact rat heart is mediated by deltal- not mu- or kappa-opioid receptors
32. + murine T cells
33. Dual signal transduction through delta opioid receptors in a transfected human T-cell line
34. Deltaopioid suppression of human immunodeficiency virus-1 expression in T cells (Jurkat)
35. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
36. Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells
37. 5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: Involvement of opioid receptors and reactive oxygen species
38. Evidence for a single functional opioid delta receptor subtype in the mouse isolated vas deferens
39. Differentiation of receptor subtypes by thermodynamic analysis: Application to opioid delta receptors
40. a6k S6 kinase
41. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
42. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
43. Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: Involvement of pertussis toxin-sensitive G proteins
44. Fas-mediated cell death promoted by opioids
45. Endogenous δ-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C
46. Retention of supraspinal delta-like analgesia and loss of morphine tolerance in δ opioid receptor knockout mice
47. Phosphorylation and regulation of Raf by Akt (Protein kinase B)