Searching for genetic determinants of human aging and longevity: Opportunities and challenges

Mechanisms of Ageing and Development

Volumn 123, Issue 2-3, 2002, Pages 195-205

  Vijg, Jan ^a   Van Orsouw, Nathalie ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Aging and longevity genes; BRCA1; Direct association studies; Single nucleotide polymorphism; Two dimensional gene scanning

Indexed keywords

AGED; AGING; ANALYTIC METHOD; BREAST CARCINOMA; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE EXPRESSION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LONGEVITY; MASS SCREENING; METHODOLOGY; PHENOTYPE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AGING; BREAST NEOPLASMS; FEMALE; FORECASTING; GENES, BRCA1; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONGEVITY; POLYMORPHISM, GENETIC;

EID: 0036132119     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00346-3     Document Type: Conference Paper

References (34)

1. Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size
2. Genetic epidemiology of single-nucleotide polymorphisms
3. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
4. DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus
5. A simple system for automated two-dimensional electrophoresis: Applications to genetic testing
6. Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population
7. Genetic testing: The problems and the promise
8. Genetics of aging
9. Length-independent separation of DNA restriction fragments in two-dimensional electrophoresis
10. Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence
11. Mutator phenotype of Werner syndrome is characterized by extensive deletions
12. Molecular analysis of phenyketonuria in Denmark: 99% of the mutations detected by denaturing gradient gel electrophoresis
13. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
14. Crossroad of aging in the nematode Caenorhabditis elegans
15. Prospects for whole-genome linkage disequilibrium mapping of common disease genes
16. Genetic analysis of ageing: Role of oxidative age and environmental stresses
17. High-speed, multi-color fluorescent two-dimensional gene scanning
18. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
19. Relative efficiency of denaturing gradient gel electrophoresis and single strand conformation polymorphism in the detection of mutations in exons five to eight of the p53 gene
20. Siblings of centenarians live longer
21. Validity of reported age and prevalence of centenarians in a New England sample
22. Searching for genetic determinants in the new millennium
23. Evolutionary theory in gerontology
24. Genetic associations with human longevity at the APOE and ACE loci
25. BRCA1 sequence analysis in women at high risk for susceptibility mutations. Risk factor analysis and implications for genetic testing
26. Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes
27. Genetics of human disease, longevity and aging
28. Mutational scanning of large genes by extensive PCR multiplexing and two-dimensional electrophoresis: Application to the RB1 gene
29. A highly accurate, low cost test for BRCA1 mutations
30. Breast cancer genes and DNA repair
31. Understanding the biology of aging: The key to prevention and therapy
32. Pleiotropy, natural selection and the evolution of senescence
33. Positional cloning of the Werner's syndrome gene