Selective inhibition of COX-2 is beneficial to mice infected intranasally with VSV

Prostaglandins and Other Lipid Mediators

Volumn 67, Issue 2, 2002, Pages 143-155

  Chen, Nannan ^a   Restivo, Andrew ^a   Reiss, Carol Shoshkes ^a,b  

^a NEW YORK UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

COX; In vivo animal models; Inflammatory mediators; Neuroimmunology; NOS

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ARACHIDONATE 5 LIPOXYGENASE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 12; NITRIC OXIDE SYNTHASE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; VESICULAR STOMATITIS VIRUS; VIRUS ENCEPHALITIS; VIRUS TITRATION;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BLOTTING, WESTERN; CENTRAL NERVOUS SYSTEM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INTERFERON TYPE II; INTERLEUKIN-12; ISOENZYMES; MEMBRANE PROTEINS; MICE; NEUTROPHILS; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOVIRIDAE INFECTIONS; SULFONAMIDES; TIME FACTORS; VESICULAR STOMATITIS-INDIANA VIRUS;

EID: 0036131379     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(01)00185-X     Document Type: Article

References (60)

1. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
2. Prostaglandin endoperoxide synthase: Why two isoforms?
3. COX-1 and COX-2 tissue expression: Implications and predictions
4. Cyclooxygenase in biology and disease
5. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
6. Cloning of sheep and mouse prostaglandin endoperoxide synthases
7. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase)
8. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment
9. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
10. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase
11. Human cyclooxygenase-2 cDNA
12. Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase
13. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells
14. Interactions of PGH synthase isozymes-1 and -2 with NSAIDs
15. Identification of a phorbol ester-repressible v-src-inducible gene
16. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells
17. Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity
18. Characterization of inducible cyclooxygenase in rat brain
19. Arachidonic acid cascade and signal transduction
20. Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders
21. Role of inducible cyclooxygenase (COX-2) in inflammation
22. Cyclooxygenase-2 is induced globally in infarcted human brain
23. Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo
24. Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain
25. Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis
26. Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement
27. Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia
28. HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclooxygenase type 2 (COX-2)
29. Rhabdovirus biology and infection: An overview
30. The earliest events in vesicular stomatitis virus infection of the murine olfactory neuroepithelium and entry of the central nervous system
31. Murine infection by vesicular stomatitis virus: Initial characterization of the H-2d system
32. Inhibition of vesicular stomatitis virus infection by nitric oxide
33. Interferon-gamma induced type I nitric oxide synthase activity inhibits viral replication in neurons
34. Neuronal expression of NOS-1 is required for host recovery from viral encephalitis
35. Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity
36. Dapsone to delay symptoms in Creutzfeldt-Jakob disease
37. Central neuropathogenesis of vesicular stomatitis virus infection of immunodeficient mice
38. Specific inhibition of leukotriene B4 (LTB4)-induced neutrophil emigration by 20-hydroxy LTB4: Implications for the regulation of inflammatory responses
39. Interleukin-12 promotes recovery from viral encephalitis
40. NSAID treatment suppresses VSV propagation in mouse CNS
41. IL-12 and viral infections
42. IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system
43. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
44. Inducible cyclooxygenase may have anti-inflammatory properties
45. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
46. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
47. PIN: An associated protein inhibitor of neuronal nitric oxide synthase
48. Distinct roles of eicosinoids in the immune response to viral encephalitis
49. Cyclooxygenase 2 promotes cell survival by stimulation of dynein light chain expression and inhibition of neuronal nitric oxide synthase activity
50. Distribution of protein inhibitor of neuronal nitric oxide synthase in rat brain
51. Expression and regulation of protein inhibitor of neuronal nitric oxide synthase in ventilatory muscles
52. Localization of protein inhibitor of neuronal nitric oxide synthase in rat kidney
53. Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen
54. Sensitivity difference to the suppressive effect of prostaglandin E2 amog mouse strains: A possible mechanism to polarize Th2 type response in BALB/c mice
55. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis
56. Sensitivity difference to the suppressive effect of prostaglandin E2 among mouse strains: A possible mechanism to polarize Th2 type response in BALB/c mice
57. Neuronal interferon-gamma immunoreactive molecule: Bioactivities and purification
58. Gamma interferon-like immunoreactivity in the rat nervous system
59. Interferon-gamma-like immunoreactivity in certain neurons of the central and peripheral nervous system
60. Leukotrienes play protective roles early during experimental VSV encephalitis