Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E2 in the lung

Chest

Volumn 121, Issue 3, 2002, Pages 102S-104S

  Jenkins, Gisli ^a   Hart, Stephen L ^a   Hodges, Rebecca J ^a   Meng, Qin Hai ^a   Kinnon, Christine ^a   Laurent, Geoffrey J ^a   McAnulty, Robin J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; INTEGRIN; INTERLEUKIN 1BETA; LIPOFECTIN; PLASMID DNA; PROSTAGLANDIN E2; RECOMBINANT DNA; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; COLLAGEN SYNTHESIS; CONFERENCE PAPER; CONTROLLED STUDY; DNA VECTOR; FIBROBLAST; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FIBROSIS; LUNG LAVAGE; MITOSIS INHIBITION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 0036126730     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.121.3_suppl.102S     Document Type: Conference Paper

References (7)

1. 2 and to express cyclooxygenase-2
2. Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-B in human fibrotic lung fibroblasts and promotes bleomycin induced fibrosis in mice
3. An integrin-targeted non-viral vector for pulmonary gene therapy
4. The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells
5. Indomethacin suppresses the anti-proliferative effects of transforming growth factor-β isoforms on fibroblast cell cultures
6. Inducible cyclooxygenase may have anti-inflammatory properties
7. Cyclooxygenase-2 (COX-2) is the predominant COX isoform upregulated following bleomycin induced lung injury