An integrin-targeted non-viral vector for pulmonary gene therapy

Gene Therapy

Volumn 7, Issue 5, 2000, Pages 393-400

  Jenkins, R G ^a   Herrick, S E ^a   Meng, Q H ^b   Kinnon, C ^b   Laurent, G J ^a   McAnulty, R J ^a   Hart, S L ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Gene therapy; Integrin targeting vector; Lung

Indexed keywords

INTEGRIN; LIPOSOME; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; INFLAMMATION; LUNG; LUNG PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPORTER GENE; RESPIRATORY TRACT DISEASE;

ADENOVIRIDAE; ANIMALIA; BRONCHUS;

EID: 0034017487     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301095     Document Type: Article

References (40)

1. Crystal RG et al. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat Genet 1994; 8: 42-51.
2. Bellon G et al. Aerosol administration of a recombinant adenovirus expressing CFTR to cystic fibrosis patients: a phase I clinical trial. Hum Gene Ther 1997; 8: 15-25.
3. Alton EW et al Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial. Lancet 1999; 353: 947-954.
4. Otake K, Ennist DL, Harrod K, Trapnell BC. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Hum Gene Ther 1998; 9: 2207-2222.
5. Yang Y, Su Q, Wilson JM. Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J Virol 1996; 70: 7209-7212.
6. Yei S et al. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum Gene Ther 1994; 5: 731-744.
7. Xiao X, Li J, Samulski RJ. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 1996; 70: 8098-8108.
8. Dong JY, Fan PD, Frizzell RA. Quantitative analysis of the packaging capacity of recombinant adeno-associated virus. Hum Gene Ther 1996; 7: 2101-2112.
9. Cotten M et al. High-efficiency receptor-mediated delivery of small and large (48) kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc Natl Acad Sci USA 1992; 89: 6094-6098.
10. Ferrari S et al. ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Therapy 1997; 4: 1100-1106.
11. Zabner J et al. Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo. J Clin Invest 1997; 100: 1529-1537.
12. Schaffer DV, Lauffenburger DA. Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery. J Biol Chem 1998; 273: 28004-28009.
13. Remy JS et al. Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses. Proc Natl Acad Sci USA 1995; 92: 1744-1748.
14. Cheng PW. Receptor ligand-facilitated gene transfer: enhancement of liposome-mediated gene transfer and expression by transferrin. Hum Gene Ther 1996; 7: 275-282.
15. Hart SL et al. Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide. J Biol Chem 1994; 269: 12468-12474.
16. Hart SL et al. Gene delivery and expression mediated by an integrin-binding peptide. Gene Therapy 1995; 2: 552-554.
17. Newham P, Humphries MJ. Integrin adhesion receptors: structure, function and implications for biomedicine. Mol Med Today 1996; 2: 304-313.
18. Rankin S, Isberg RR, Leong JM. The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells. Infect Immun 1992; 60: 3909-3912.
19. Bai M, Campisi L, Freimuth P. Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12, but not by adenovirus type 2. J Virol 1994; 68: 5925-5932.
20. Bergelson JM et al. Identification of the integrin VLA-2 as a receptor for echovirus 1. Science 1992; 255: 1718-1720.
21. Hart SL et al. Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector. Hum Gene Ther 1998; 9: 575-585.
22. McLachlan G et al. Laboratory and clinical studies in support of cystic fibrosis gene therapy using pCMV-CFTR-DOTAP. Gene Therapy 1996; 3: 1113-1123.
23. Logan JJ et al. Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium. Gene Therapy 1995; 2: 38-49.
24. Alton EW et al. Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat Genet 1993; 5: 135-142.
25. Oudrhiri N et al. Gene transfer by guanidinium-cholesterol cationic lipids into airway epithelial cells in vitro and in vivo. Proc Natl Acad Sci USA 1997; 94: 1651-1656.
26. Fortunati E et al. In vitro and in vivo gene transfer to pulmonary cells mediated by cationic liposomes. Biochim Biophys Acta 1996; 1306: 55-62.
27. Engelhardt JF, Litzky L, Wilson JM. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum Gene Ther 1994; 5: 1217-1229.
28. Yang Y et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994; 7: 362-369.
29. Thorne PS, McCray PB Jr, Howe TS, O'Neill MA. Early-onset Sinflammatory responses in vivo to adenoviral vectors in the presence or absence of lipopolysaccharide-induced inflammation. Am J Respir Cell Mol Biol 1999; 20: 1155-1164.
30. Krieg AM. Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA. Trends Microbiol 1996; 4: 73-76.
31. Dong JY et al. Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector. Hum Gene Ther 1996; 7: 319-331.
32. Croyle MA et al. Role of integrin expression in adenovirus-mediated gene delivery to the intestinal epithelium. Hum Gene Ther 1998; 9: 561-573.
33. Sawa T et al. Intraluminal water increases expression of plasmid DNA in rat lung. Hum Gene Ther 1996; 7: 933-941.
34. Yew NS et al. Contribution of plasmid DNA to inflammation in the lung after administration of cationic lipid:pDNA complexes. Hum Gene Ther 1999; 10: 223-234.
35. Thompson JF, Hayes LS, Lloyd DB. Modulation of firefly luciferase stability and impact on studies of gene regulation. Gene 1991; 103: 171-177.
36. Smith RL, Geller AI, Escudero KW, Wilcox CL. Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector. J Virol 1995; 69: 4593-4599.
37. Rosenfeld MA et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 1992; 68: 143-155.
38. Mastrangeli A et al. Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J Clin Invest 1993; 91: 225-234.
39. Weiss DJ, Liggitt D, Clark JG. In situ histochemical detection of beta-galactosidase activity in lung: assessment of X-gal reagent in distinguishing lacZ gene expression and endogenous beta-galactosidase activity. Hum Gene Ther 1997; 8: 1545-1554.
40. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.