Phenytoin-induced teratogenesis: A molecular basis for the observed developmental delay during neurulation

Epilepsia

Volumn 38, Issue 4, 1997, Pages 415-423

  Bennett, Gregory D ^a   Lau, Franciscus ^a   Calvin, James A ^a   Finnell, Richard H ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Developmental delay; In situ transcription aRNA; Phenytoin; Teratology

Indexed keywords

CADHERIN; CELLULAR RETINOL BINDING PROTEIN; COLLAGEN TYPE 4; COMPLEMENTARY RNA; ONCOPROTEIN; PHENYTOIN; PROTEIN; PROTEIN BCL 2; PROTEIN EMX 2; PROTEIN WEE 1; RETINOIC ACID RECEPTOR; TRANSCRIPTION FACTOR PAX3; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; FEMALE; GENE EXPRESSION; MALE; MOUSE; NEURULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TERATOGENESIS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CADHERINS; CELL CYCLE PROTEINS; CENTRAL NERVOUS SYSTEM; COLLAGEN; DNA-BINDING PROTEINS; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; GENES, JUN; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED STRAINS; NERVE TISSUE PROTEINS; NEURAL TUBE DEFECTS; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PHENYTOIN; PREGNANCY; PROTEIN-TYROSINE KINASES; RECEPTORS, RETINOIC ACID; RETINOL-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 0030901099     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1997.tb01730.x     Document Type: Article

References (70)

1. Finnell RH, Heinz N, Yerby MS. Teratogenicity of antiepileptic drugs. 1995;4:209-30.
2. Hanson JW, Smith DW. The fetal hydantoin syndrome. J Pediatr 1975;87:285-90.
3. Hanson JW, Myrianthopoulos NC, Harvey MAS, et al. Risks to offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J Pediatr 1976;89: 662-8.
4. Hanson JW. Teratogen update: fetal hydantoin effects. Teratology 1986;33:349-53.
5. Bustamante SA, Stumpff LC. Fetal hydantoin syndrome in triplets: a unique experiment of nature. Am J Dis Child 1978;132:978-9.
6. Schinzel A. Fetals hydantoin-Syndrom bei Geschwistern. Schweiz Med Wochenschr 1979;109:68-72.
7. Smith DW. Hydantoin effects on the fetus. In: Hassell TM, Johnston MC, Dudley KH, eds. Phenytoin-induced teratology and gingival pathology. New York: Raven Press, 1980:35-40.
8. Finnell RH, DiLiberti JH. Hydantoin-induced teratogenesis: are arene oxide intermediates really responsible? Helv Pediatr Acta 1983;38:171-7.
9. Dansky LV, Finnell RH. Parental epilepsy, anticonvulsant drugs and reproductive outcome: epidemiological and experimental findings spanning three decades. II. Human studies. Reprod Toxicol 1991;5:281-99.
10. Rodier PM, Ingram JL, Tisdale B, Nelson S, Romano J. Developmental anomalies of the cranial nerve motor nuclei in autism. J Comp Neurol 1997 (in press).
11. Stromland K, Nordin V, Miller M, et al. Autism in thalidomide embryopathy: a population study. Dev Med Child Neurol 1994;36: 351-6.
12. Miller MT, Stromland K. Thalidomide embryopathy: an insight into autism? Teratology 1993;47:387-8.
13. Miller MT. Thalidomide embryopathy: a model for the study of congenital incomitant horizontal strabismus. Trans Am Ophthalmol Soc 1991;89:623-74.
14. Musselman AC, Bennett GD, Greer KA, Eberwine JH, Finnell RH. Phenytoin induced alterations of early embryonic gene expression. Reprod Toxicol 1994;8:383-95.
15. Finnell RH. Phenytoin-induced teratogenesis: a mouse model. Science 1981;211:483-4.
16. Finnell RH, Chernoff GF. Gene-teratogen interactions: an approach to understanding the metabolic basis of birth defects. In: Nau H, Scott WJ, eds. Drug disposition in teratogenesis, vol. II. New York: CRC Press, 1987:97-112.
17. Snell GD, Fekete E, Hummel KP. The relation of mating, ovulation and the estrus smear in the house mouse to the time of day. Anat Rec 1948;76:30-54.
18. Finnell RH, Kerr BM, van Waes M, Steward RL, Levy RH. Protection from phenytoin-induced congenital malformations by co-administration of the antiepileptic drug stiripentol in a mouse model. Epilepsia 1994;35:131-48.
19. Theiler K. The house mouse, 2nd ed. Springer-Verlag, Berlin. 1989.
20. Stemple DL, Anderson DJ. Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell 1992;71:973-85.
21. Eberwine JH, Yen H, Miyashiro K, et al. Analysis of gene expression in single live neurons. Proc Natl Acad Sci USA 1992;89: 3010-4.
22. Eberwine JH, Spencer CM, Miyashiro K, Mackler SA, Finnell RH. cDNA synthesis in situ: methods and applications. In: Wu G, ed: Methods in enzymology. New York: New York Press 1992:80-100.
23. Wlodarczyk B, Bennett GD, Calvin JA, Craig JC, Finnell RH. Arsenic-induced alterations in embryonic transcription factor gene expression: implications for abnormal neural development. Dev Genet 1996;18:306-15.
24. Neter J, Wasserman W, Kuter MH. In: Irwin RD, ed. Applied linear regression models. Boston: 0000:10-44.
25. Sokal RR, Rohlf FJ. Biometry, 2nd ed. San Francisco: W.H. Freeman, 1981.
26. Cole WA, Trasler DG. Gene-teratogen interaction in insulin induced mouse exencephaly. Teratology 1980;22:125-39.
27. Finnell RH, Buehler BA, Kerr BM, Ager PL, Levy RH. Clinical and experimental studies linking oxidative metabolism to phenytoin-induced teratogenesis. Neurology 1992;42(suppl 5):25-31.
28. Finnell RH, van Waes M, Musselman A, Kerr BM, Levy RH. Differences in the patterns of phenytoin-induced malformations following stiripentol coadministration in three inbred mouse strains. Reprod Toxicol 1993;7:439-48.
29. Finnell RH, van Waes M, Bennett GD, Eberwine JH. Lack of concordance between heat shock proteins and the development of tolerance to teratogen-induced neural tube defects. Dev Genet 1993;14:137-47.
30. Hill RM, Verniaud WM, Horning MG, McCulley LB, Morgan MF. Infants exposed in utero to antiepileptic drugs. Am J Dis Child 1974;127:645-53.
31. Nelson KB, Ellenberg JH. Maternal seizure disorder outcomes of pregnancy and neurologic abnormalities in the children. Neurology 1982;32:1247-54.
32. Speidel BD, Meadow SR. Maternal epilepsy and abnormalities of the fetus and newborn. Lancet 1972;2:839-43.
33. Vanoverloop D, Schnell RR, Harvey EA, Holmes LB. The effects of prenatal exposure to phenytoin and other anticonvulsants on intellectual function of 4 to 8 years of age. Neurotoxicol Teratol 1992;14:329-35.
34. Leavitt AM, Yerby MS, Robinson N, Sells CJ, Erickson DM. Epilepsy and pregnancy: developmental outcomes at 12 months. Neurology 1992;42:141-3.
35. Vorhees CV, Weisenburger WP, Acuff-Smith KD, Minck DR. An analysis of factors influencing complex water maze learning in rats: effects of task complexity, path order and escape assistance on performance following prenatal exposure to phenytoin: Neurotoxicol Teratol 1991;13:213-22.
36. Vorhees CV, Acuff-Smith KD, Moran MS, Minck DR. A new method for evaluating air-righting reflex ontogeny in rats using prenatal exposure to phenytoin to demonstrate delayed development. Neurotoxicol Teratol 1994;16:563-73.
37. Schoenwolf GC, Smith JL. Mechanisms of neurulation: traditional viewpoint and recent advances. Development 1990;109:243-70.
38. Jacobson AG, Oster GF, Odell GM, Cheng LY. Neurulation and the cortical tractor model for epithelial folding. J Embryol Exp Morphol 1986;96:19-49.
39. Angel P, Allegretto EA, Okino ST, et al. Oncogene jun encodes a sequence-specific transactivator similar to AP-1. Nature 1988;332: 166-71.
40. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with cFOs forming complexes of different DNA binding affinities. Cell 1988;55:917-24.
41. Kovary K, Bravo R. The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol 1991;11:4466-72.
42. Smith MJ, Prochownik EV. Inhibition of c-jun causes reversible proliferative arrest and withdrawal from the cell cycle. Blood 1992; 79:2107-15.
43. Estus S, Zales WJ, Greeman RS, Gruda M, Bravo R, Johnson EM Jr. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 1994;127:1717-27.
44. +, a gene encoding a protein kinase homolog. Cell 1987;49:559-63.
45. wee1 mitosis inhibitor is a tyserine/serine kinase. Nature 1991;349:808-11.
46. Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D, Mik1 and wee1 cooperate in the inhibitory tyrosinc phosphorylation of cdc 2. Cell 1991;64:111-7.
47. + functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. Cell 1987;49:569-76.
48. + functions as an inducer in the mitotic control of fission yeast. Cell 1986;45:145-8.
49. Lagunowich LA, Donoso LA, Grunwald GB. Identification of mammalian and invertebrate analogues of the avian calcium-dependent cell adhesion protein N-cadherin with synthetic-peptide directed antibodies against a conserved cytoplasmic domain. Biochem Biophys Res Commun 1990;172:313-20.
50. Bronner-Fraser M, Wolf JJ, Murray BA. Effects of antibodies against N-cadherin and N-CAM on the cranial neural crest and neural tube. Dev Biol 1992;153:291-301.
51. Detrick RJ, Dickey D, Kintner CR. The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron 1990;4:493-506.
52. Lagunowich LA, Stein AP, Reuhl KR. N-Cadherin in normal and abnormal brain development. Neurotoxicology 1994;15:123-32.
53. Redies C, Takeichi M. Expression of N-cadherin mRNA during development of the mouse brain. Dev Dynam 1993;197:26-39.
54. Duband J, Thiery JP. Distribution of laminin and collagens during avian neural crest development. Development 1987;101:461-78.
55. Cooper AR, McQueen A. Subunits of laminin are differentially synthesized in mouse eggs and early embryos. Dev Biol 1983;96: 467-71.
56. Burdsal CA, Damsky CH, Pederson RA. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development 1993;118:829-44.
57. Akers RM, Mosher DF, Lilien JE. Promotion of retinal neurite outgrowths by substratum bound fibronectin. Dev Biol 1981;86: 179-88.
58. Carbonetto S, Gruvor MM, Turner DC. Nerve fiber growth in culture on fibronectin collagen, and glycosaminoglycan substrates. J Neurosci 1983;3:2324-35.
59. Tomaselli KJ, Reichardt LF, Bixby JL. Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. J Cell Biol 1986;103:2659-72.
60. Hall DE, Neugbauer KM, Reichard LF. Embryonic neural retinal cell response to extracellular matrix proteins: developmental changes and effects of the CSAT antibody. J Cell Biol 1987;104: 623-34.
61. O'Shea KS, Rheinheimer JS, D'Amato CJ, Hickson SP. Alterations in the neuroepithelial basal lamina in a neurological mutant with prenatal hydrocephalus. J Neuropathol Exp Neurol 1988;47: 507-15.
62. Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992;80:879-86.
63. Tsujimoto Y. Stress-resistance conferred by high level of Bcl-2 protein in human B lymphoblastoid cell line. Oncogene 1989;4: 1331-6.
64. Nunez G, London L, Hockenberg D, Alexander M, McKearn J, Korsmeyer SJ. Deregulated Bcl-2 gene expression selection prolongs survival of growth factor deprived hematopoietic cell lines. J Immunol 1990;144:3602-10.
65. Walton MI, Wh'song D, O'Conner PM, Hockenbery D, Korsmeyer SJ, Kohn KW. Constitutive expression of human Bcl-2 modulates nitrogen mustard and coamptothecin induced apoptosis. Cancer Res 1993;53:1853-61.
66. Miyashita T, Reed JC. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 1993;81: 151-7.
67. Ignotz R, Endo T, Massague J. Cell adhesion protein receptors as targets for TGF-β action. Cell 1987;51:189-97.
68. Pelton RW, Dickinson ME, Moses HL, Hogan BL. In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2. Development 1990;110:609-20.
69. Pelton RW, Saexna B, Jones M, Moses HL, Gold LI. Immunohistochemical localization of TGF beta 1, and beta 2 and beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol 1991;115:1091-105.
70. Danielson MK, Danielsson BRG, Marchner H, Lundin M, Rundqvist E, Reiland S. Histopathological and hemodynamic studies supporting hypoxia and vascular disruption as an explanation to phenytoin teratogenicity. Teratology 1992;46:485-97.