Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic leukemia

Cancer Immunology, Immunotherapy

Volumn 51, Issue 2, 2002, Pages 72-78

  Pospíšilová, Dagmar ^a   Borovičková, Jiřina ^a   Poloučková, Andrea ^a   Špíšek, Radek ^a   Šedivá, Anna ^a   Hrušák, Ondřej ^a   Starý, Jan ^a   Bartůňková, Jiřina ^a  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

Author keywords

Dendritic cell; Immunotherapy; Jurkat cell line; Tumor antigen pulsation

Indexed keywords

CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 4; TRYPAN BLUE; TUMOR ANTIGEN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLAST CELL; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELL INTERACTION; CELL KILLING; CELL LYSATE; CELL MATURATION; CELL POPULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DENDRITIC CELL; DISEASE MARKER; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERFERON PRODUCTION; IRRADIATION; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; TARGET CELL; TH1 CELL; TUMOR IMMUNITY;

ANTIGENS, NEOPLASM; CANCER VACCINES; CELL SURVIVAL; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; HUMANS; IMMUNOPHENOTYPING; IMMUNOTHERAPY; INTERFERON TYPE II; INTERLEUKIN-12; LEUKEMIA, LYMPHOCYTIC, ACUTE; LYMPHOCYTE ACTIVATION;

EID: 0036124593     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-001-0253-3     Document Type: Article

References (21)

1. Dendritic cells acquire from apoptotic cells and induce class I-restricted CTLs
2. Generation of dendritic cells from peripheral blood adherent cells in medium with human serum
3. Dendritic cells
4. Dendritic cells and the control of immunity
5. + cytotolytic T cell responses
6. + T cells
7. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
8. Human acute myeloblastic leukemia cells differentiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemias
9. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells
10. Cytokine-driven differentiation of blasts from patients with acute myelogenous and lymphoblastic leukemia into dendritic cells
11. Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses
12. Vaccination of melanoma patiens with peptide or tumor lysate-pulsed dendritic cells
13. Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages
14. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells
15. Proliferating dendritic cell progenitors in human blood
16. Vitiligo in patients with melanoma: Normal issue antigens can be targets for cancer immunotherapy
17. Dendritic cell-based immunotherapy of prostate cancer
18. Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells
19. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte-macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
20. Consequences of cell death: Exposure to necrotic tumor cells, but primary tissue cells or apoptotic cells, induces the maturation of stimulatory dendritic cells
21. Standardized generation of fully mature p70 IL-12 secreting monocyte-derived dendritic cells for clinical use