Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell energy, which is reversible

Glycobiology

Volumn 12, Issue 1, 2002, Pages 25-32

  Argibay, Pablo F ^a   Di Noia, Javier M ^b   Hidalgo, Alejandra ^a   Mocetti, Esteban ^a   Barbich, Mariana ^a   Lorenti, Alicia S ^a   Bustos, Daniel ^a   Tambutti, Monica ^a   Hyon, Sung H ^a   Frasch, Alberto C C ^b   Sánchez, Daniel O ^b  

^a HOSPITAL ITALIANO DE BUENOS AIRES   (Argentina)

^b INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

Author keywords

Immunomodulation; Mucins; T. cruzi

Indexed keywords

GLYCOCONJUGATE; INTERLEUKIN 2; MUCIN; PROTEINASE; SIALIDASE; SIALOGLYCOPROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CLONAL ANERGY; CONTROLLED STUDY; EUKARYOTIC CELL; GENE EXPRESSION; GENETIC TRANSFECTION; GLYCOSYLATION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MAMMAL CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROCESSING; SIALYLATION; T LYMPHOCYTE; TRYPANOSOMA CRUZI; VERO CELL;

ANIMALS; APOPTOSIS; CELL DIVISION; CERCOPITHECUS AETHIOPS; CLONAL ANERGY; DOWN-REGULATION; HUMANS; LYMPHOCYTE ACTIVATION; MUCINS; T-LYMPHOCYTES; TRYPANOSOMA CRUZI; VERO CELLS;

ANIMALIA; EUKARYOTA; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0036120875     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. A neutral glycoprotease of Pasteurella haemolytica A1 specifically cleaves O-sialoglycoproteins
2. In vitro induction of MUC-1 peptide-specific type 1 T lymphocytes and cytotoxic T lymphocytes responses from healthy multiparous donors
3. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2
4. Helper T cells infiltrating human renal cell carcinomas have the phenotype of activated memory-like T lymphocytes
5. Trypanosoma cruzi surface mucin expressed on eukaryotic cells inhibit lymphocyte proliferation and recognition both in vivo and in vitro
6. Reversal of in vitro T cell anergy by IL-2 stimulation
7. The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells
8. High diversity in mucin genes and mucin molecules in Trypanosoma cruzi
9. The Trypanosoma cruzi mucin family is transcribed from hundreds of genes having hypervariable regions
10. AU-rich elements in the 3′-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency
11. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells
12. A new technique for the assay of infectivity of human adenovirus 5 DNA
13. NetOglyc: Prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility
14. Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes
15. Trypanosomal immunosuppressive factor: A secretion product(s) of Trypanosoma cruzi that inhibits proliferation and IL-2 receptor expression by activated human peripheral blood mononuclear cells
16. Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium
17. Trans-sialidase from Trypanosoma cruzi induces apoptosis in cells from the immune system in vivo
18. Cyclophosphamide-induced immunological tolerance: An overview
19. The surface protein superfamily of Trypanosoma cruzi stimulates a polarized Th1 response that becomes anergic
20. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
21. Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-α-galactosyl antibodies
22. Trypanosoma cruzi surface mucins with exposed variant epitopes
23. Incorporation of sialic acid into Trypanosoma cruzi macro-molecules. A proposal for a new metabolic route
24. An unusually small gene encoding a putative mucin-like glycoprotein in Trypanosoma cruzi
25. Glycosylation and the immune system
26. Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8(+) TC1 cells: Loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and cytokines
27. Mucin-like glycoproteins linked to the membrane by glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalysed by trans-sialidase in metacyclic forms of Trypanosoma cruzi
28. Evidence of the participation of the Ssp-3 antigen in the invasion of non-phagocytic mammalian cells by Trypasoma cruzi
29. Selective suppressive effects of Trypanosoma cruzi infection on IL-2, c- myc, and c-fos gene expression
30. Trypanosoma cruzi-induced suppression of IL-2 production. I. Evidence for the presence of IL-2-producing cells
31. Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells