Cyclophosphamide-induced immunological tolerance: An overview

Immunobiology

Volumn 195, Issue 2, 1996, Pages 129-139

  Mayumi, Hisanori ^a   Umesue, Masayoshi ^b   Nomoto, Kikuo ^b  

^a NATIONAL HOSPITAL ORGANIZATION KYUSHU MEDICAL CENTER   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

CHIMERA; CLONAL ANERGY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SUPPRESSOR CELL; T LYMPHOCYTE;

EID: 0029838458     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-2985(96)80033-7     Document Type: Article

References (74)

1. SCHWARTZ, R., and W. DAMESHEK. 1959. Drug-induced immunological tolerance. Nature 183: 1682.
2. MEEKER, W. R., R. M. CONDIE, R. A. GOOD, and R. L. VARCO. 1960. Alteration of homograft response by antimetabolites. Ann. N. Y. Acad. Sci. 87: 203.
3. STERZL, J. 1960. Inhibition of the inductive phase of antibody formation by 6-mercaptopurine examined by the transfer of isolated cells. Nature 185: 256
4. ROBINSON, J. L., and C. L. CHRISTIAN. 1960. 6-Mercaptopurine in immunological responsiveness. Nature 187: 796.
5. CALNE, R. Y. 1960. The rejection of renal homografts inhibition in dogs by 6-mercaptopurine. Lancet 1: 417.
6. UPHOFF, D. E. 1961. Drug-induced immunological «tolerance» for homotransplantation. Transplant. Bull. 28: 110.
7. MCLAREN, A. 1961. Induction of tolerance to skin homografts in adult mice treated with 6-mercaptopurine. Transplant. Bull. 28: 479.
8. MAGUIRE, H. C., and H. I. MAIBACH. 1961. Specific immune tolerance to anaphylactic sensitization (egg albumin) induced in the guinea pig by cyclophosphamide (Cytoxan). J. Allergy 32: 406.
9. BERENBAUM, M. C. 1963. Prolongation of homograft survival in mice with single doses of cyclophosphamide. Nature 200: 84.
10. SUTTON, W. T., F. V. HAGEN, B. H. GRIFFITH, and F. W. PRESTON. 1963. Drug effects on survival of homografts of skin. Arch. Surgery 87: 840.
11. FOX, M. 1964. Suppression of tissue immunity by cyclophosphamide. Transplantation 64: 475.
12. SANTOS, G. W., and A. H. OWENS. 1965. A comparison of the effects of selected cytotoxic agents on allogeneic skin graft survival in rat. Bull. Johns Hopkins Hosp. 116: 327
13. FLOERSHEIM, G. L. 1972. Curative potencies against amanitin poisoning by cytochrome C. Science 177: 808.
14. AISENBERG, A. C. 1967. Studies on cyclophosphamide-induced tolerance to sheep erythrocytes. J. Exp. Med. 125: 833.
15. HALLE, P. O., M. C. MARTYRE, and M. CHAUVANET. 1970. Prolongation of skin graft survival in mice by pretreatment with H-2 antigen and cyclophosphamide. Rev. Eur. Etudes. Clin. Biol. 15: 1090.
16. PEVNITSKY, L. A., V. V. SOLOVIEV, L. N. FONTALIN, and R. K. ANDRESON. 1971. Prolonged chimerism of the lymphoid tissue obtained in adult mice with the aid of cyclophosphamide. Bull. Exp. Biol. Med. 8: 71.
17. NIRMUL, G., C. SERVERIN, and R. N. TAUB. 1971. Cyclophosphamide-induced immunologic tolerance to skin homografts. Surg. Forum 22: 287.
18. STARZL, T. E., C. G. HALGRIMSON, I. PENN, G. MARTINEAU, G. SCHROTER, H. AMEMIYA, C. W. PUTNAM, and C. G. GROTH. 1971. Cyclophosphamide and human organ transplantation. Lancet 2: 70.
19. KRIPKE, M. L., D. STEINMLULLER, C. C. HARRIS, P. E. LOFGREEN, and E. J. EICHWALD. 1973. Brief communication: effects of chronic cyclophosphamide and methotrexate treatment on skin allograft survival in mice and rats. J. Natl. Cancer Inst. 51: 1355.
20. WINKELSTEIN, A. 1973. Mechanisms of immunosuppression: effects of cyclophosphamide on cellular immunity. Blood 41: 273.
21. MARQUET, R., and G. HEYSTEK. 1975. The induction and abolition of specific immunosuppression of heart allografts in rats by use of donor blood and cyclophosphamide. J. Immunol. 115: 405.
22. BRENT, L., and S. C. OPARA. 1979. Specific unresponsiveness to skin allografts in mice. V. Synergy between donor tissue extract, procarbazine hydrochloride, and antilymphocyte serum in creating a long-lasting unresponsiveness mediated by suppressor T cells. Transplantation 27: 120.
23. MAYUMI, H., and K. TOKUNAGA. 1990. Cyclophosphamide-induced chimera-type tolerance to allografts: an overview of drug-induced immunological tolerance Fukuoka Acta Med. 81: 20.
24. KELLY, W. D., M. F. MCKNEALLY, F. OLIVERAS, C. MARTINEZ, and R. A. GOOD. 1966. Cell-free antigenic material employed to produce tolerance to skin grafts: tissue sources, preservation, dose requirements and the effects of combined use with azathioprine and sublethal irradiation. Ann. N. Y. Acad. Sci. 129: 210.
25. STARZL, T. E., A. J. DEMETRIS, N. MURASE, S. ILDSTAD, C. RICORDI, and M. TRUCCO. 1992. Cell migration, chimerism, and graft acceptance. Lancet 339: 1579.
26. STARZL, T. E., A. J. DEMETRIS, M. TRUCCO, C. RICORDI, S. ILDSTAD, P. I. TERASAKI, N. MURASE, R. S. KENDALL, M. KOCOVA, W. A. RUDERT, A. ZEEVI, and D. VAN THIEL. 1993. Chimerism after liver transplantation for type IV glycogen storage disease and type 1 Gaucher's disease. N. Engl. J. Med. 328: 745.
27. STOCKMAN, G. D., L. R. HEIM, M. A. SOUTH, and J. J. TRENTIN. 1973. Differential effects of cyclophosphamide on the B and T cell compartments of adult mice. J. Immunol. 110: 277.
28. MURASE, N., T. E. STARZL, A. J. DEMETRIS, L. VALDIVIA, M. TANABE, D. CRAMER, and L. MAKOWKA. 1993. Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs. Transplantation 55: 701.
29. SHIN, T., H. MAYUMI, K. HIMENO, H. SANUI, and K. NOMOTO. 1984. Drug-induced tolerance to allografts in mice. I. Difference between tumor and skin grafts. Transplantation 37: 580.
30. MAYUMI, H., K. HIMENO, N. TOKUDA, and K. NOMOTO. 1986. Drug-induced tolerance to allograft in mice. VII. Optimal protocol and mechanism of cyclophosphamide-induced tolerance in an H-2 haplotype-identical strain combination. Transplant. Proc. 18: 363.
31. MAYUMI, H., N. TOKUDA, J. L. FAN, K. HIMENO, and K. NOMOTO. 1987. Drug-induced tolerance of allografts in mice. XIII. Tolerance to the H-Y antigen. Transplant. Proc. 19: 2975.
32. MAYUMI, H., and R. A. GOOD. 1989. Long-lasting skin allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigen barriers by a tolerance-inducing method using cyclophosphamide. J. Exp. Med. 169: 213.
33. FONTALIN, L. N., I. CHERNYAKHOVSKAYA, H. MAYUMI, and R. A. GOOD. 1991. Recent state of cyclophosphamide-induced skin allograft tolerance in mice. Immunobiology 182: 323.
34. MAYUMI, H., and K. NOMOTO. 1992. A major difference in the mechanisms of neonatally induced tolerance and cyclophosphamide-induced tolerance. Transplantation. 53: 499.
35. MAYUMI, H., T. SHIN, K. HIMENO, and K. NOMOTO. 1985. Drug-induced tolerance to allografts in mice II. Tolerance to tumor allografts of large doses associated with rejection of skin allografts and tumor allografts of small doses. Immunobiology 169: 147.
36. MAYUMI, H., K. HIMENO, T. SHIN, and K. NOMOTO. 1985. Drug-induced tolerance to allografts in mice. IV. Mechanisms and kinetics of cyclophosphamide-induced tolerance. Transplantation 39: 209.
37. MAYUMI, H., K. HIMENO, N. TOKUDA, J. L. FAN, and K. NOMOTO. 1987. Drug-induced tolerance to allografts in mice. X. Augmentation of split tolerance in murine combinations disparate at both H-2 and non-H-2 antigens by the use of spleen cells from donors preimmunized with recipient antigens. Immunobiology 174: 274.
38. FAN, J. L., H. MAYUMI, N. TOKUDA, K. HIMENO, and K. NOMOTO. 1987. Drug-induced tolerance to allografts in mice. XI. Tolerance induction using F1 (donor x recipient) spleen cells as a tolerogen. Transplant. Proc. 19: 3513.
39. MAYUMI, H., K. HIMENO, T. SHIN, and K. Nomoto. 1985. Drug-induced tolerance to allografts in mice. VI. Tolerance induction in H-2-haplotype-identical strain combinations in mice. Transplantation 40: 188.
40. MAYUMI, H., and R. A. GOOD. 1989. Induction of tolerance across major barriers using a two-step method with genetic analysis of tolerance induction. Immunobiology 179: 86.
41. MATSUURA, A., M. KATSUNO, Y. SUZUKI, T. ITO, K. YASUURA, T. ABE, and Y. YOSHIKAI. 1994. Cyclophosphamide-induced tolerance in fully allogeneic heart transplantation in mice. Cell. Immunol. 155: 501.
42. MAEDA, T., M. ETO, Y. NISHIMURA, KE. NOMOTO, Y. Y. KONG, and KI. NOMOTO. 1993. Direct evidence for clonal destruction of allo-reactive T cells in the mice treated with cyclophosphamide after allo-priming. Immunology 78: 113.
43. DUTTON, R. W., and R. I. MISHELL. 1967. Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes: analysis by the hot pulse technique. J. Exp. Med. 126: 443.
44. SALMON, S. E., R. S. KRAKAUER, and W. F. WHITMORE. 1971. Lymphocyte stimulation: selective destruction of cells during blastogenic response to transplantation antigens. Science 172: 490.
45. ZOSCHKE, D. C., and F. H. BACH. 1970. Specificity of antigen recognition by human lymphocytes in vitro. Science 170: 1404.
46. TOKUDA, N., H. GONDO, H. MAYUMI, K. TANIGUCHI, K. HIMENO, and K. NOMOTO. 1986. Drug-induced in vitro tolerance to allogeneic antigens. I. Establishment of a tolerance induction system in a fully allogeneic murine combination. Transplantation 42: 281.
47. TOKUDA, H., H. MAYUMI, K. HIMENO, H. GONDO, J. L. FAN, and K. NOMOTO. 1988. Drug-induced in vitro tolerance to allogeneic antigens. II. Further analysis of in vitro-tolerized spleen cells in a fully allogeneic murine combination. Transplantation 45: 464.
48. MAYUMI, H., K. HIMENO, K. TANAKA, N. TOKUDA, J. L. FAN, and K. NOMOTO. 1986. Drug-induced tolerance to allografts in mice. IX. Establishment of complete chimerism by allogeneic spleen cell transplantation from donors made tolerant to H-2-identical recipients. Transplantation 42: 417.
49. MAYUMI, H., and R. A. GOOD. 1989. The necessity of both allogeneic antigens and stem cells for cyclophosphamide-induced skin allograft tolerance in mice. Immunobiology 178: 287.
50. + T cells in cyclophosphamide-induced tolerance to H-2-compatible, Mls-disparate antigens. J. Exp. Med. 171: 97.
51. ETO, M., H. MAYUMI, Y. TOMITA, Y. YOSHIKAI, Y. NISHIMURA, and K. NOMOTO. 1990. Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion. J. Immonol. 145: 1303.
52. ETO, M., H. MAYUMI, Y. TOMITA, Y. YOSHIKAI, Y. NISHIMURA, and K. NOMOTO. 1990. The requirement of intrathymic mixed chimerism and clonal deletion for a long-lasting skin allograft tolerance in cyclophosphamide-induced tolerance. Eur. J. Immunol. 20: 2005.
53. ETO, M., H. MAYUMI, Y. NISHIMURA, T. MAEDA, Y. YOSHIKAI, and K. NOMOTO. 1991. Similarity and difference in the mechanisms of neonatally induced tolerance and cyclophosphamide-induced tolerance in mice. J. Immunol. 147: 2439.
54. TOMITA, Y., K. AYUKAWA, Y. YOSHIKAI, and K. NOMOTO. 1992. Mechanisms of cyclophosphamide-induced tolerance to IE-encoded alloantigens: evidence of clonal deletion in MHC antigen-reactive cells for skin allograft rejection. Transplantation 53: 602.
55. MAEDA, T., M. ETO, Y. NISHIMURA, KE. NOMOTO, Y. Y. KONG, and KI. NOMOTO. 1993. Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice. J. Immunol. 150: 753.
56. TOMITA, Y., Y. NISHIMURA, N. HARADA, M. ETO, K. AYUKAWA, Y. YOSHIKAI, and K. NOMOTO. 1990. Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion. J. Immunol. 145: 4026.
57. TOMITA, Y., H. MAYUMI, M. ETO, and K. NOMOTO. 1990. Importance of suppressor T cells in cyclophosphamide-induced tolerance to the non-H-2-encoded alloantigens: is mixed chimerism really required in maintaining a skin allograft tolerance? J. Immunol. 144: 463.
58. KAPPLER, J. W., N. ROEHM, and P. MARRACK. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49: 273.
59. KAPPLER, J. W., U. STAERZ, J. WHITE, and P. C. MARRACK. 1988. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35.
60. a-encoded antigens. Nature 332: 40.
61. a-encoded antigens. J. Exp. Med. 167: 2005.
62. NOMOTO, KE., M. ETO, K. YANAGA, Y. NISHIMURA, T. MAEDA, and KI. NOMOTO. 1992. Interference with cyclophosphamide-induced skin allograft tolerance by cyclosporin A. J. Immunol. 149: 2668.
63. DUKOR, P., and F. M. DIETRICH. 1970. Prevention of cyclophosphamide-induced tolerance to erythrocytes by pretreatment with cortisone. Proc. Soc. Exp. Biol. Med. 133: 280.
64. MAYUMI, H., K. KAYASHIMA, T. SHIN, and K. NOMOTO. 1985. Drug-induced tolerance to allografts in mice. V. Prolongation of skin graft survival in tolerant mice with combined immunosuppressive treatments. Transplantation 39: 335.
65. ALEXANDER, J. W., S. MASROOR, A. LEVY, and K. GALLA. 1994. A new strategy for prolonging xenograft survival. Transplantation 58: 14.
66. MAYUMI, H., K. HIMENO, N. TOKUDA, and K. NOMOTO. 1985. Drug-induced tolerance to allografts in mice. VIII. Effects of thymectomy and/or splenectomy on tolerance induction in an H-2-haplotype-indentical strain combination. Transplantation 40: 438.
67. OPELZ, G., and P. I. TERASAKI. 1973. Effect of splenectomy on human renal transplants. Transplantation 15: 605.
68. ALEXANDRE, G. P., J. P. SQUIFFLET, B. M. DE, D. LATINNE, R. REDING, P. GIANELLO, M. CARLIER, and Y. PIRSON. 1987. Present experiences in a series of 26 ABO-incompatible living donor renal allografts. Transplant. Proc. 19: 4538.
69. ABU-ELMAGD, K., O. BRONSTHER, A. JAIN, W. IRISH, H. RAMOS, J. R. MARINO, F. DODSON, R. SELBY, H. DOYLE, H. FURUKAWA, T. GAYOWSKI, B. NOUR, J. REYES, G. MAZARIEGOS, A. PINNA, A. RAO, P. FONTES, A. CASAVILLA, N. JABBOUR, W. MARSH, J. MADARIAGA, A. J. DEMETRIS, A. TZAKIS, S. TODO, S. IWATSUKI, J. J. FUNG, and T. E. STARZL. 1993. Recent advances in hepatic transplantation at the University of Pittsburgh. In: TERASAKI, P. I., and J. M. CECKA. (eds.). Clinical Transplants 1993. UCLA Tissue Typing Laboratory, Los Angeles, Calif., 137 pp.
70. CHERNYAKHOVSKAYA, I., T. B. PRIGOZHINA, E. V. NAGURSKAYA, and L. N. FONTALIN. 1984. Immunological status of mice with long-standing allogeneic or xenogeneic neonatal heart grafts. Transplantation 38: 267.
71. MAYUMI, H., K. HIMENO, K. TANAKA, N. TOKUDA, J. L. FAN, and K. NOMOTO. 1987. Drug-induced tolerance to allografts in mice. XII. The relationships between tolerance, chimerism, and graft-versus-host disease. Transplantation 44: 286.
72. ETO, M., H. MAYUMI, Y. TOMITA, Y. YOSHIKAI, Y. NISHIMURA, T. MAEDA, T. ANDO, and K. NOMOTO. 1991. Specific destruction of host-reactive mature T cells of donor origin prevents graft-versus-host disease in cyclophosphamide-induced tolerant mice. J. Immunol. 46: 1402.
73. NISHIMURA, Y., H. MAYUMI, Y. TOMITA, M. ETO, T. MAEDA, and K. NOMOTO. 1991. Recombinant human granulocyte colony-stimulating factor improves the compromised state of recipient mice without affecting the induction of specific tolerance in the cyclophosphamide-induced tolerance system. J. Immunol. 146: 2639.
74. UMESUE, M., H. MAYUMI, Y. NISHIMURA, Y. Y. KONG, K. OMOTO, Y. MURAKAMI, KE. NOMOTO, and KI. NOMOTO. 1995. Xenogeneic (rat→mouse) skin tolerance induced by monoclonal antibodies, xenogeneic cells, and cyclophosphamide. Transplant. Proc. 27: 315.