Imaging of P glycoprotein function in vivo with PET

Novartis Foundation Symposium

Volumn 243, Issue , 2002, Pages 137-148

  Hendrikse, N H ^a   Vaalburg, W ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; DAUNORUBICIN; GLYCOPROTEIN P; TUMOR PROTEIN; VERAPAMIL;

ACTIVE TRANSPORT; ANIMAL; BLOOD BRAIN BARRIER; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DRUG ANTAGONISM; ELECTRON; HUMAN; MOUSE; MULTIDRUG RESISTANCE; PHYSIOLOGY; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; COLCHICINE; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; ELECTRONS; HUMANS; MICE; NEOPLASM PROTEINS; P-GLYCOPROTEIN; TOMOGRAPHY, EMISSION-COMPUTED; VERAPAMIL;

EID: 0036110741     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (30)

1. Abbott NJ, Revest PA 1991 Control of brain endothelial permeability. Cerebrovasc Brain Metab Rev 3:39-72
2. Bertrand Y, Capdeville R, Balduck N, Philippe N 1992 Cyclosporin A used to reverse drug resistance increases vincristine neurotoxicity. Am J Hematol 40:158-159
3. Choo EF, Leake B, Wandel et al 2000 Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos 28:655-660
4. Cole SP, Bhardwaj G, Gerlach JH et al 1992 Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654
5. Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR 1990 Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38:1277-1287
6. Elsinga PH, Franssen EJF, Hendrikse NH et al 1996 Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET. J Nucl Med 37:1571-1575
7. Ford JM, Hait WM 1990 Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42:155-199
8. Friedenberg WR, Anderson J, Wolf BC, Cassileth PA, Oken MM 1993 Modified vincristine, doxorubicin, and dexamethasone regimen in the treatment of resistant or relapsed chronic lymphocytic leukemia. An Eastern Cooperative Oncology Group study. Cancer 71:2983-2989
9. Hendrikse NH, De Vries EGE, Fluks E, Van der Graaf WTA, Vaalburg W, Franssen EJF 1998a P-glycoprotein mediated kinetics in tumor bearing rats with carbon-11-daunorubicin and positron emission tomography. Proc Am Assoc Cancer Res 39:488
10. Hendrikse NH, Schinkel AH, De Vries et al 1998b Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography. Br J Pharmacol 124:1413-1418
11. Hendrikse NH, De Vries EGE, Eriks-Fluks E et al 1999 A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier. Cancer Res 59:2411-2416
12. Higgins CF 1992 ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8:67-113
13. Huai-Yun H, Secrest DT, Mark KS et al 1998 Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. Biochem Biophys Res Commun 243:816-820
14. Hunter AL, Klaassen CD 1975 Biliary excretion of colchicine. J Pharmacol Exp Ther 192:605-617
15. Kim AE, Dintaman JM, Waddell DS, Silverman JA 1998 Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J Pharmacol Exp Ther 286:1439-1445
16. Kusuhara H, Suzuki H, Naito M, Tsuruo T, Sugiyama Y 1998 Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. J Pharmacol Exp Ther 285:1260-1265
17. Lazarowski A, Sevlever G, Taratuto A, Massaro M, Rabinowicz A 1999 Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr Neurol 21:731-734
18. Levin VA 1980 Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23:682-684
19. 3H]colchicine. J Nucl Med 33:1373-1377
20. Mehta BM, Rosa E, Biedler JL, Larson SM 1994 in vivo uptake of carbon-14-colchicine for identification of tumor multidrug resistance. J Nucl Med 35:1179-1184
21. Mehta BM, Levchenko A, Rosa E et al 1996 Evaluation of carbon-14-colchicine biodistribution with whole-body quantitative autoradiography in colchicine-sensitive and -resistant xenografts. J Nucl Med 37:312-314
22. Regina A, Koman A, Piciotti M et al 1998 Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J Neurochem 71:705-715
23. Rubin LI, Staddon JM 1999 The cell biology of the blood-brain barrier. Annu Rev Neurosci 22: 11-28
24. Schinkel AH, Smit JJM, Van Tellingen O et al 1994 Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502
25. Schinkel AH, Wagenaar E, Mol CA, Van Deemter L 1996 P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97:2517-2524
26. Seetharaman S, Barrand MA, Maskell L, Scheper RJ 1998 Multidrug resistance-related transport protein in isolated human brain microvessels and in cells cultured from these isolates. J Neurochem 70:1151-1159
27. Shiraki N, Hamada Y, Yasuda K, Fujii J, Arimori K, Nakano M 2000 Inhibitory effect of human immunodeficiency virus protease inhibitors on multidrug resistance transporter P-glycoproteins. Biol Pharm Bull 23:1528-1531
28. Tsuij A, Terasaki T, Takabatake Y et al 1992 P-glycoprotein as drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci 51:1427-1437
29. Weber DM, Dimopoulos MA, Alexanian R 1993 Increased neurotoxicity with VAD-cyclosporin in multiple myeloma. Lancet 341:558-559
30. Weber DM, Dimopoulos MA, Sinicrope F, Alexanian R 1995 VAD-cyclosporine therapy for VAD-resistant multiple myeloma. Leuk Lymphoma 19:159-163