Morphometric evaluation of the neuroprotective effect of deprenyl on postaxotomic motor neuron losses

Clinical Neuropharmacology

Volumn 25, Issue 2, 2002, Pages 75-78

  Panahi, Merziah ^a   Al Tiraihi, Taki ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

Deprenyl; Motor neuron; Neuroprotective; Sciatic nerve; Spinal cord

Indexed keywords

SELEGILINE;

ANALYSIS OF VARIANCE; ARTICLE; CALCULATION; CONTROLLED STUDY; EVALUATION; MORPHOMETRICS; MOTOR NEURON DISEASE; NERVE FIBER TRANSECTION; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; REGRESSION ANALYSIS; SCIATIC NERVE; SPINAL CORD MOTONEURON;

ANIMALS; ANIMALS, NEWBORN; AXOTOMY; CELL COUNT; DRUG EVALUATION, PRECLINICAL; MONOAMINE OXIDASE INHIBITORS; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SELEGILINE;

EID: 0036108845     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-200203000-00003     Document Type: Article

References (22)

1. Deprenyl and pergolide rescue spinal motor neurons from axotomy-induced neuronal death in the neonatal rat
2. Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: Correlation with trkB and trkC mRNA levels and isoforms
3. Axotomy-induced apoptotic cell death of neonatal rat facial motor neurons: Time course analysis and relation to NADPH-diaphorase activity
4. Development of survival responsiveness to brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5, but not to nerve growth factor, in cultured motoneurons from chick embryo spinal cord
5. Deprenyl reduces the death of motor neurons caused by axotomy
6. (-)-Deprenyl alters the time course of death of axotomized facial motor neurons and the hypertrophy of neighboring astrocytes in immature rats
7. Selegiline can mediate neuronal rescue rather than neuronal protection
8. 1-Deprenyl, blocking apoptosis and regulating gene expression in cultured retinal neurons
9. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)-deprenyl
10. mRNA expression of neurotrophins and members of the trk family in the rat brain after treatment with 1-deprenyl
11. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse
12. A dose-ranging study of selegiline in patients with Parkinson's disease: Effect of platelet monoamine oxidase activity
13. An analysis of treatment options and outcome in patients with Parkinson's disease and severe dyskinesias
14. Selegiline: An appraisal of the basis of its pharmacoeconomic and quality-of-life benefits in Parkinson's disease
15. Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments
16. 1-Deprenyl potentiates cAMP-induced elevation of FGF-2 mRNA levels in rat cortical astrocytes
17. The optimal dosage of (-)deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats
18. The role of apoptosis and excitotoxicity in the death of spinal motor neurons and interneurons after neonatal nerve injury
19. Age-dependent induction of nitric oxide synthase activity in facial motor neurons after axotomy
20. Pharmacodynamics: Mechanisms of drug and the relationship between drug concentration and effect