The microcell hybrid-based "elimination test" identifies a 1-Mb putative tumor-suppressor region at 3p22.2-p22.1 centromeric to the homozygous deletion region detected in lung cancer

Genes Chromosomes and Cancer

Volumn 34, Issue 3, 2002, Pages 341-344

  Kholodnyuk, Irina D ^a,b   Kost Alimova, Marija ^a   Yang, Ying ^a   Kiss, Hajnalka ^a   Fedorova, Ludmila ^a   Klein, George ^a   Imreh, Stefan ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b A Kirchenstein Institute of Microbiology and Virology   (Latvia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CENTROMERE; CHROMOSOME PAINTING; DERIVATIZATION; GENE DELETION; GENE LOCATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HYBRIDIZATION; LUNG CANCER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; TUMOR SUPPRESSOR GENE;

ANIMALS; CENTROMERE; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; DATABASES, GENETIC; GENE ORDER; GENES, TUMOR SUPPRESSOR; HOMOZYGOTE; HUMANS; HYBRID CELLS; LUNG NEOPLASMS; MICE; MICE, SCID; TUMOR CELLS, CULTURED;

HOMO; HOMO SAPIENS;

EID: 0036107926     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10068     Document Type: Article

References (15)

1. Molecular cloning of a candidate tumor suppressor gene. DLC1, from chromosome 3p21.3
2. The role of deletions at the FRA3B/FHIT locus in carcinogenesis
3. Nonrandom loss of human chromosome 3 fragments from mouse/human microcell hybrids following progressive growth in SCID mice
4. Differential elimination of 3p and retention of 3q segments in human/mouse microcell hybrids during tumor growth
5. A 3p21.3 region is preferentially eliminated from human chromosome 3/mouse microcell hybrids during tumor growth in SCID mice
6. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CERI) in 3p21.3
7. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3
8. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes
9. Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome
10. High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss
11. Homozygous deletions at 3p12 in breast and lung cancer
12. Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM
13. High resolution chromosome 3p allelo-typing of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
14. A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid derived SCID tumors
15. Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice