Third-generation dihydropyridine-type calcium channel blocker labedipinedilol-B displays α/β-adrenoceptor blocking activities

Drug Development Research

Volumn 52, Issue 3, 2001, Pages 462-474

  Yeh, Jwu Lai ^a   Tsai, Chieh Ho ^a   Liang, Jhy Chong ^a   Wu, Jiunn Ren ^a   Huang, Yeun Chih ^b   Chen, Ing Jun ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b DEVELOPMENT CENTER FOR BIOTECHNOLOGY   (Taiwan)

Author keywords

adrenoceptor blockade; 1,4 Dihydropyridine; Calcium channel blockade; Radioligand binding assay; Vasorelaxant effect

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHLORIDE; DIHYDROPYRIDINE DERIVATIVE; ISOPRENALINE; LABEDIPINEDILOL A; LABEDIPINEDILOL B; NORADRENALIN; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BRADYCARDIA; BRAIN; CELL CULTURE; CHRONOTROPISM; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG BINDING; DRUG MECHANISM; EXTRACELLULAR CALCIUM; GUINEA PIG; HEART VENTRICLE; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; INOTROPISM; LUNG; MALE; NONHUMAN; RAT; TACHYCARDIA; VASCULAR SMOOTH MUSCLE;

EID: 0034965151     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1148     Document Type: Article

References (3)

1. Baird JRC, Linnell J. 1972. The assessment of β-adrenoceptor blocking potency and cardioselectivity in vitro and in vivo. J Pharm Pharmacol 24:880-885.
2. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Chen IJ, Lions SJ, Liou SS, Lin CN. 1993. Xanthonolol: a calcium channel and β-adrenoceptor blocker with vasodilating properties. Gen Pharmacol 24:1425-1433.