Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats

Clinical and Experimental Pharmacology and Physiology

Volumn 29, Issue 5-6, 2002, Pages 381-385

  Uchida, Takanori ^a   Okumura, Kenji ^a   Ito, Takayuki ^a   Kamiya, Hiroki ^a   Nishimoto, Yasuhiro ^a   Yamada, Michiharu ^a   Tomida, Takahito ^a   Matsui, Hideo ^a   Hayakawa, Tetsuo ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin converting enzyme inhibitor; Aortic rings; Insulin resistance; Phenylephrine

Indexed keywords

ACETYLCHOLINE; DIPEPTIDYL CARBOXYPEPTIDASE; FRUCTOSE; GLUCOSE; INSULIN; PHENYLEPHRINE; QUINAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CARBOHYDRATE DIET; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SPECIFICITY; GLUCOSE BLOOD LEVEL; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; RAT; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA;

ACETYLCHOLINE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; AORTA, THORACIC; BLOOD GLUCOSE; BLOOD PRESSURE; FRUCTOSE; HYPERTENSION; INSULIN; INSULIN RESISTANCE; ISOQUINOLINES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDROISOQUINOLINES; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 0036096567     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2002.03668.x     Document Type: Article

References (40)

1. Role of insulin resistance in human disease
2. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
3. Insulin and hypertension
4. The vasodilator action of insulin. Implications for the insulin hypothesis of hypertension
5. Insulin-mediated vasodilation: Impairment with increased blood pressure and body mass
6. Insulin resistance in essential hypertension
7. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension
8. Effect of captopril on glucose concentration. Possible role of augmented postprandial forearm blood flow
9. Effects of quinapril and losartan on insulin sensitivity in genetic hypertensive rats with different metabolic abnormalities
10. Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus
11. Differential effects of quinaprilat and enalaprilat on endothelial function of conduit arteries in patients with chronic heart failure
12. Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers
13. Fructose-induced insulin resistance and hypertension in rats
14. Chronic sucrose ingestion induces mild hypertension and tachycardia in rats
15. Vanadyl sulfate lowers plasma insulin and blood pressure in spontaneously hypertensive rats
16. Somatostatin inhibition of fructose-induced hypertension
17. Improved insulin sensitivity by bezafibrate in rats: Relationship to fatty acid composition of skeletal-muscle triglycerides
18. Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension
19. + channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide
20. + channel in the relaxation of bovine tracheal smooth muscle by glyceryl trinitrate and sodium nitroprusside
21. Bradykinin may not be involved in improvement of insulin resistance by angiotensin converting enzyme inhibitor
22. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man
23. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans
24. Endothelial-dependent vascular effects of insulin and insulin-like growth factor I in the perfused rat mesenteric artery and aortic ring
25. Synergistic actions of insulin and troglitazone on contractility in endothelium-denuded rat aortic rings
26. - imbalance in insulin-resistant rat aorta
27. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
28. Genetic factors determine the blood pressure response to insulin resistance and hyperinsulinemia: A call to refocus the insulin hypothesis of hypertension
29. Insulin sensitivity in the pathogenesis of hypertension and hypertensive complications
30. Insulin resistance associated with compensatory hyperinsulinemia as an independent risk factor for vasospastic angina
31. Demonstration of insulin resistance in coronary artery disease documented with angiography
32. Insulin attenuates norepinephrine-induced venoconstriction. An ultrasonographic study
33. The effect of insulin on vascular reactivity to norepinephrine
34. Effects of insulin on vasoconstrictive responses to norepinephrine and angiotensin II in rabbit femoral artery and vein
35. Vascular insulin resistance in fructose-hypertensive rats
36. ACE-inhibition with quinapril modulates the nitric oxide pathway in normotensive rats
37. Direct angiotensin converting enzyme inhibitor-mediated venodilation
38. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
39. Nitric oxide release accounts for insulin's vascular effects in humans
40. Quinapril treatment enhances vascular sensitivity to insulin