Interleukin-2 induces increased platelet-endothelium interactions: A potential mechanism of toxicity

Journal of Laboratory and Clinical Medicine

Volumn 128, Issue 1, 1996, Pages 75-82

  Lentsch, Alex B ^a   Edwards, Michael J ^a   Miller, Frederick N ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030200201     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(96)90115-8     Document Type: Article

References (23)

1. Edwards MJ, Miller FN, Sims DE, Abney DL, Schuschke DA, Corey TS. Interleukin 2 acutely induces platelet and neutrophil-endothelial adherence and macromolecular leakage. Cancer Res 1992;52:3425-31.
2. Oleksowicz L, Zuckerman D, Mrowiec Z, Puszkin E, Dutcher JP. Effects of interleukin-2 administration on platelet function in cancer patients. Am J Hematol 1994;45:224-31.
3. Cotran RS, Pober JS, Gimbrone MA Jr, et al. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. J Immunol 1988; 140:1883-8.
4. Nawroth PP, Stern DM. Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986;163:740-5.
5. Nawroth PP, Handley DA, Esmon CT, Stern DM. Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 1986;83:3460-4.
6. Nakagawa K, Miller FN, Sims DE, Lentsch AB, Miyazaki M, Edwards MJ. Mechanisms of interleukin-2-induced hepatic toxicity. Cancer Res 1996;56:507-10.
7. Siegel JP, Puri RK. Interleukin-2 toxicity. J Clin Oncol 1991; 9:694-704.
8. Rosenblum WI, El-Sabban F. Platelet aggregation in the cerebral microcirculation: effect of aspirin and other agents. Circ Res 1977;40:320-8.
9. Herrmann KS. Platelet aggregation induced in the hamster cheek pouch by a photochemical process with excited fluorescein isothiocyanate-dextran. Microvasc Res 1983;26:238-9.
10. Sato M, Ohshima N. Platelet thrombus induced in vivo by filtered light and fluorescent dye in mesenteric microvessels of the rat. Thromb Res 1984;35:319-34.
11. Lindberg RA, Slaaf DW, Lentsch AB, Miller FN. Involvement of nitric oxide and cyclooxygenase products in photoactivation-induced microvascular occlusion. Microvasc Res 1994;47:203-21.
12. Girotti AW. Photodynamic lipid peroxidation in biological systems. Photochem Photobiol 1990;51:497-509.
13. Valenzeno DP. Photomodification of biological membranes with emphasis on singlet oxygen mechanisms. Photochem Photobiol 1987;46:147-60.
14. McCaffery PJ, Berridge MV. Expression of the leukocyte functional molecule (LFA-1) on mouse platelets. Blood 1986; 67:1757-64.
15. Piguet PF, Vesin C, Ryser JE, Senaldi G, Grau GE, Tacchini-Cottier F. An effector role for platelets in systemic and local lipopolysaccharide-induced toxicity in mice, mediated by a CD11a-and CD54-dependent interaction with endothelium. Infect Immun 1993;61:4182-7.
16. Anderson GL, Miller FN, Xiu R-J. Inhibition of histamine-induced protein leakage in rat skeletal muscle by blockade of prostaglandin synthesis. Microvasc Res 1984;28:51-61.
17. Movat HZ, Burrowes CE, Cybulsky MI, Dinarello CA. Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am J Pathol 1987;129:463-76.
18. Sims DE, Miller FN, Donald A, Home MM, Edwards MJ. Interleukin-2 alters the positions of capillary and venule pericytes in rat cremaster muscle. J Submicrosc Cytol Pathol 1994;26:507-13.
19. Weidmann E, Bergmann L, Stock J, Kirsten R, Mitrou PS. Rapid cytokine release in cancer patients treated with interleukin-2. J Immunother 1992;12:123-31.
20. Numerof RP, Aronson FR, Mier JW. IL-2 stimulates the production of IL-1a and IL-1b by human peripheral blood mononuclear cells. J Immunol 1988;141:4250-7.
21. Endo Y, Nakamura M. Active translocation of platelets into sinusoidal and Disse spaces in the liver in response to lipopolysaccharides, interleukin-1 and tumor necrosis factor. Gen Pharmacol 1993;24:1039-53.
22. McCuskey RS, Urbaschek R, McCuskey PA, Urbaschek B. Hepatic microvascular responses to tumor necrosis factor. In: Wisse E, Knook DL, Decker K, eds. Cells of the hepatic sinusoid (vol 2). Rijswijk, The Netherlands: Kupffer Cell Foundation, 1989:272-6.
23. Nishida J, McDonnell D, Krasovich MA, Ekataksin W, McCuskey RS. Effects of interleukin-1-alpha on hepatic phagocytic cells and sinusoidal microcirculation. In: Knook DL, Wisse E, eds. Cells of the hepatic sinusoid (vol 4). Leiden, The Netherlands: Kupffer Cell Foundation, 1993:148-51.