Naturally occurring mutations and functional polymorphisms in multidrug resistance 1 gene: Correlation with microsatellite instability and lymphoid infiltration in colorectal cancers [4]

Journal of Medical Genetics

Volumn 39, Issue 5, 2002, Pages 340-346

  Potocnik U ^a   Ravnik Glavac M ^a   Golouh, R ^a   Glavač, Damjan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; LETTER; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MDR1 GENE; MICROSATELLITE INSTABILITY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; SLOVENIA;

BASE SEQUENCE; CELL MOVEMENT; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA, NEOPLASM; GENES, MDR; GERM-LINE MUTATION; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTES; MICROSATELLITE REPEATS; MUTATION; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 0036093562     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (22)

1. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine
2. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene
3. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
4. A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
5. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
6. Expression of a multidrug-resistance gene in human tumors and tissues
7. Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis
8. Genetic susceptibility to non-polyposis colorectal cancer
9. Loss of DNA mismatch repair in acquired resistance to cisplatin
10. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis
11. The grading of rectal cancer: Historical perspectives and a multivariate analysis of 447 cases
12. Causes of microsatellite instability in colorectal tumors: Implications for hereditary non-polyposis colorectal cancer screening
13. Sensitivity of single-strand conformation polymorphism and heteroduplex method for mutation detection in the cystic fibrosis gene
14. A bisulfite method of 5-methylcytosine mapping that minimizes template degradation
15. Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells
16. Biochemistry of multidrug resistance mediated by the multidrug transporter
17. A mutation in the promoter of the multidrug resistance gene (MDR1) in human hematological malignancies may contribute to the pathogenesis of resistant disease
18. A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
19. Tissue-specific enhancer of the human multidrug-resistance (MDR1) gene
20. Point mutations in the mdr1 promoter of human osteosarcomas are associated with in vitro responsiveness to multidrug resistance relevant drugs
21. Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
22. Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors