Molecular phenotype distinguishes two subsets of gastric low-grade mucosa-associated lymphoid tissue lymphomas

Laboratory Investigation

Volumn 82, Issue 5, 2002, Pages 535-541

  Nardini, Elena ^a   Rizzi, Simona ^a   Ménard, Sylvie ^a   Balsari, Andrea ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE; COMPLEMENTARITY DETERMINING REGION; GENE AMPLIFICATION; GENE MUTATION; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOHISTOCHEMISTRY; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SOMATIC MUTATION; SOUTHERN BLOTTING; STOMACH LYMPHOMA;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES, ANTIBODY; BLOTTING, SOUTHERN; COMPLEMENTARITY DETERMINING REGIONS; CONSENSUS SEQUENCE; DNA, NEOPLASM; GASTRIC MUCOSA; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULIN SWITCH REGION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOHISTOCHEMISTRY; LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TISSUE; MOLECULAR SEQUENCE DATA; PHENOTYPE; STOMACH NEOPLASMS;

EID: 0036091690     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780447     Document Type: Article

References (31)

1. H gene expression among human follicular lymphomas
2. Antigen selection in human lymphomagenesis
3. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT Lymphoma Study Group
4. Maturation of the immune response in germinal centers
5. Immunoglobulin heavy chain diversity genes rearrangement pattern indicates that MALT-type gastric lymphoma B cells have undergone an antigen selection process
6. H genes are inherently susceptible to amino acid replacement
7. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion
8. The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma
9. Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis
10. Immunoglobulin VH genes of highgrade mucosa-associated lymphoid tissue lymphomas show a high load of somatic mutations and evidence of antigen-dependent affinity maturation
11. Mantle cell (previously centrocytic) lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle
12. Immunoglobulin specificity of low-grade B cell gastrointestinal lymphoma of mucosa-associated lymphoid tissue (MALT) type
13. Cellular origin of human B cell lymphomas
14. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
15. Somatic mutation in human B cell tumors
16. Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells
17. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features
18. Helicobacter pylori eradication for the treatment of gastric low-grade MALT lymphoma: Follow-up together with sequential molecular studies
19. B cell monoclonality precedes the development of gastric MALT lymphoma in Heficobacter pylori-associated chronic gastritis
20. Detection of aberrant isotype switch recombination in low-grade and high grade gastric MALT lymphomas
21. Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: Evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis
22. Somatic hypermutation in lowgrade mucosa-associated lymphoid tissue-type B cell lymphoma
23. Clonal selection and learning in the antibody system
24. Lack of allelic exclusion in B cell chronic lymphocytic leukemia
25. Eradication of Helicobacter pylori infection in primary lowgrade gastric lymphoma of mucosa-associated lymphoid tissue
26. Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue: An uncontrolled trial
27. Ongoing somatic mutations and clonal expansions after cure of Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue B cell lymphoma
28. Helicobacter pylori-associated gastritis and primary B cell gastric lymphoma
29. CDR3 sequences of MALT lymphoma show homology with those of autoreactive B cell lines
30. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection
31. Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach