Effects of aldosterone on biosynthesis, traffic, and functional expression of epithelial sodium channels in A6 cells

Journal of General Physiology

Volumn 119, Issue 5, 2002, Pages 427-442

  De La Rosa, Diego Alvarez ^a   Li, Hui ^a   Canessa, Cecilia M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biotinylation; Cellular traffic; ENaC; Open probability; Short circuit current

Indexed keywords

ALDOSTERONE; SODIUM; SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; BIOTINYLATION; CELL CULTURE; ENDOCYTOSIS; GLYCOSYLATION; KINETICS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; TOAD; ANIMAL; CELL LINE; CELL MEMBRANE; DRUG EFFECT; EPITHELIUM CELL; GENETIC TRANSCRIPTION; GENETICS; HALF LIFE TIME; METABOLISM; PATCH CLAMP; PHYSIOLOGY; PROTEIN TRANSPORT; XENOPUS LAEVIS;

ALDOSTERONE; ANIMAL; CELL LINE; CELL MEMBRANE; EPITHELIAL CELLS; GLYCOSYLATION; HALF-LIFE; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PROTEIN TRANSPORT; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS; ANIMALS; EPITHELIAL SODIUM CHANNEL;

EID: 0036091599     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028559     Document Type: Article

References (40)

1. The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes
2. Structure and regulation of amiloride-sensitive sodium channels
3. Aldosteroneinduced increase in the abundance of Na+ channel subunits
4. Mineralocorticoid receptor knockout mice: Pathophysiology of Na+ metabolism
5. Stimulation of sodium transport by aldosterone and arginine vasotocin in A6 cells
6. Epithelial sodium channel regulated by aldosterone-induced protein sgk
7. Protease modulation of the activity of the epithelial sodium channel expressed in Xeopus oocytes
8. Phosphorylation of Nedd4-2 by Sgkl regulates epithelial Na(+) channel cell surface expression
9. Regulation of Na channels in the rat cortical collecting tubule: Effects of cAMP and methyl donors
10. Epithelial sodium channels: Function, structure, and regulation
11. Biotinylation and assessment of membrane polarity: Caveats and methodological concerns
12. Trafficking and cell surface stability of ENaC expressed in epithelial MDCK cells
13. Vasopressin-stimulated electrogenic sodium transport in A6 cells is linked to a Ca (2+) -mobilizing signal mechanism
14. Time-dependent stimulation by aldosterone of blocker-sensitive ENaCs in A6 epithelia
15. A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel
16. Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia
17. Cell surface expression and turnover of the alpha-subunit of the epithelial sodium channel
18. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: Possible role of SGK
19. Effects of vasopressin and cAMP on single amiloride-blockable Na channels
20. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney
21. Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes
22. Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A6 renal cells
23. Regulation of Na channels of the rat cortical collecting tubule by aldosterone
24. The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells
25. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and desoxycorticosterone
26. Carboxylmethylation of the beta subunit of xENaC regulates channel activity
27. Trafficking and cell surface stability of ENaC
28. Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome
29. The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis
30. In vivo phosphorylation of the epithelial sodium channel
31. Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel
32. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination
33. Isoprenylcysteine-O-carboxyl methyltransferase regulates aldosterone-sensitire Na(+) reabsorption
34. S-adennsyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of epithelial Na(+) channels
35. Regulation of rENaC mRNA by dietary NaCl and steroids: Organ, tissue, and steroid heterogeneity
36. Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone
37. Biosynthesis and processing of epithelial sodium channels in Xenopus oocytcs
38. An epithelial serine protease activates the amiloridesensitive sodium channel
39. Noncoordinate regulation of endogenous epithelial sodium channel (ENaC) subunit expression at the apical membrane of A6 cells in response to various transporting conditions