The insulin-3 gene: Lack of a genetic basis for human cryptorchidism

Journal of Urology

Volumn 167, Issue 6, 2002, Pages 2534-2537

  Baker, Linda A ^a,b   Nef, Serge ^a,b   Nguyen, Michael T ^a,b   Stapleton, Ronita ^a,b   Pohl, Hans ^a,b   Parada, Luis F ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Abnormalities; Cryptorchidism; Gene expression; Urethra

Indexed keywords

DNA FRAGMENT; GENE PRODUCT; INSULIN 3 PROTEIN; PROTEIN INSL 3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYPTORCHISM; GENE MUTATION; HUMAN; KNOCKOUT MOUSE; LEYDIG CELL; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TESTIS DESCENT;

EID: 0036090566     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65029-X     Document Type: Article

References (22)

1. The natural history of testicular descent
2. Cryptorchidism: A prospective study of 7500 consecutive male births, 1984-8
3. Apparent doubling of frequency of undescended testis in England and Wales in 1962-81
4. Endocrine disruption: Emerging science vitally important for pediatric urologists
5. Cryptorchidism in mice mutant for Insl3
6. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism
7. Familial bilateral cryptorchidism
8. Structural organization of the porcine and human genes coding for a Leydig cell specific insulin-like peptide (LEY-I-L) and chromosomal localization of the human gene (INSL3)
9. The embryology of testicular descent
10. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells
11. Biology of the relaxin-like factor (RLF)
12. The human Leydig insulin-like (Ley-I-L) gene is expressed in the corpus luteum and trophoblast
13. Mouse Leydig insulin-like (Ley-I-L) gene: Structure and expression during testis and ovary development
14. Absence of mutations involving the INSL3 gene in human idiopathic cryptorchidism
15. A common polymorphism in the human relaxin-like factor (RLF) gene: No relationship with cryptorchidism
16. A molecular basis for estrogen-induced cryptorchidism
17. Involvement of insulin-like factor 3 (Insl3) in diethylstilbestrol-induced cryptorchidism
18. Specific, high affinity relaxin-like factor receptors
19. Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism
20. Different insulin-like 3 (INSL3) gene mutations are not associated with human cryptorchidism
21. Novel insulin-like 3 (INSL3) gene mutation associated with human cryptorchidism